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    BDKRB2 bradykinin receptor B2 [ Homo sapiens (human) ]

    Gene ID: 624, updated on 28-Oct-2024

    Summary

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    Official Symbol
    BDKRB2provided by HGNC
    Official Full Name
    bradykinin receptor B2provided by HGNC
    Primary source
    HGNC:HGNC:1030
    See related
    Ensembl:ENSG00000168398 MIM:113503; AllianceGenome:HGNC:1030
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B2R; BK2; BK-2; BKR2; BRB2
    Summary
    This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. Bradykinin is released upon activation by pathophysiologic conditions such as trauma and inflammation, and binds to its kinin receptors, B1 and B2. The B2 receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. [provided by RefSeq, Apr 2020]
    Expression
    Broad expression in urinary bladder (RPKM 13.5), gall bladder (RPKM 13.3) and 16 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See BDKRB2 in Genome Data Viewer
    Location:
    14q32.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (96204839..96244164)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (90436088..90475413)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (96671176..96710501)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6051 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6052 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8981 Neighboring gene chromosome 14 open reading frame 132 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96519945-96520444 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:96526720-96526873 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:96529045-96529222 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8982 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:96552361-96553560 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_38841 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96560846-96561346 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96561347-96561847 Neighboring gene uncharacterized LOC124903374 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96563297-96563798 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8983 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96642023-96642523 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:96658061-96658668 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:96659886-96660494 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:96660495-96661102 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96661103-96661710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96661711-96662318 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96664109-96664715 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96670637-96671512 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:96697669-96697864 Neighboring gene CDC28 protein kinase regulatory subunit 1B pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:96719533-96720042 Neighboring gene uncharacterized LOC124903375 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:96734992-96736191 Neighboring gene NANOG hESC enhancer GRCh37_chr14:96748657-96749197 Neighboring gene bradykinin receptor B1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_38870 Neighboring gene autophagy related 2B Neighboring gene uncharacterized LOC124903430

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Lack of association of a 9 bp insertion/deletion polymorphism within the bradykinin 2 receptor gene with myocardial infarction. Fischer M, et al. Clin Sci (Lond), 2004 Nov. PMID 15301669
    2. Optical biosensor provides insights for bradykinin B(2) receptor signaling in A431 cells. Fang Y, et al. FEBS Lett, 2005 Nov 21. PMID 16263113
    3. 3'-Untranslated region of the type 2 bradykinin receptor is a potent regulator of gene expression. Zamorano R, et al. Am J Physiol Renal Physiol, 2006 Feb. PMID 16144969
    4. Relationship of bradykinin B2 receptor gene polymorphism with essential hypertension and left ventricular hypertrophy. Fu Y, et al. Hypertens Res, 2004 Dec. PMID 15894833
    5. Bradykinin β2 receptor -58T/C gene polymorphism and essential hypertension: a meta-analysis. Li YY, et al. PLoS One, 2012. PMID 22900090, Free PMC Article

    See all (233) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bradykinin receptor expression and bradykinin-mediated sensitization of human sensory neurons.
      Title: Bradykinin receptor expression and bradykinin-mediated sensitization of human sensory neurons.
    2. Function and structure of bradykinin receptor 2 for drug discovery.
      Title: Function and structure of bradykinin receptor 2 for drug discovery.
    3. The Role of Bradykinin Receptors in Hereditary Angioedema Due to C1-Inhibitor Deficiency.
      Title: The Role of Bradykinin Receptors in Hereditary Angioedema Due to C1-Inhibitor Deficiency.
    4. Cryo-EM structures of human bradykinin receptor-Gq proteins complexes.
      Title: Cryo-EM structures of human bradykinin receptor-G(q) proteins complexes.
    5. ACE2 internalization induced by a SARS-CoV-2 recombinant protein is modulated by angiotensin II type 1 and bradykinin 2 receptors.
      Title: ACE2 internalization induced by a SARS-CoV-2 recombinant protein is modulated by angiotensin II type 1 and bradykinin 2 receptors.
    6. Polymorphism of the bradykinin type 2 receptor gene modulates blood pressure profile and microvascular function in prepubescent children.
      Title: Polymorphism of the bradykinin type 2 receptor gene modulates blood pressure profile and microvascular function in prepubescent children.
    7. Association of Variants Near the Bradykinin Receptor B2 Gene With Angioedema in Patients Taking ACE Inhibitors.
      Title: Association of Variants Near the Bradykinin Receptor B(2) Gene With Angioedema in Patients Taking ACE Inhibitors.
    8. Potentiation of B2 receptor signaling by AltB2R, a newly identified alternative protein encoded in the human bradykinin B2 receptor gene.
      Title: Potentiation of B2 receptor signaling by AltB2R, a newly identified alternative protein encoded in the human bradykinin B2 receptor gene.
    9. BDKRB2 is a novel EMT-related biomarker and predicts poor survival in glioma.
      Title: BDKRB2 is a novel EMT-related biomarker and predicts poor survival in glioma.
    10. Down-regulation of B2R contributes to preeclampsia by inhibiting human trophoblast cell invasion and angiogenesis.
      Title: Down-regulation of B2R contributes to preeclampsia by inhibiting human trophoblast cell invasion and angiogenesis.
    Submit: New GeneRIF Correction See all GeneRIFs (169)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of bradykinin receptor B2 (BDKRB2) in primary human brain microvascular endothelial cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: BDKRB1

    Homology

    Clone Names

    • DKFZp686O088

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables bradykinin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bradykinin receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol phospholipase C activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables type 1 angiotensin receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in arachidonate secretion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in blood circulation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in inflammatory response IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of vascular permeability IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in regulation of vasoconstriction IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in response to salt stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in smooth muscle contraction IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vasodilation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    B2 bradykinin receptor
    Names
    BK-2 receptor

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000623.4 → NP_000614.1  B2 bradykinin receptor

      See identical proteins and their annotated locations for NP_000614.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AL355102
      Consensus CDS
      CCDS9942.1
      UniProtKB/Swiss-Prot
      P30411
      UniProtKB/TrEMBL
      B4DRL4, Q68DM8
      Conserved Domains (1) summary
      cd15381
      Location:58 → 343
      7tmA_BK-2; bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001379692.1 → NP_001366621.1  B2 bradykinin receptor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AL355102
      Consensus CDS
      CCDS9942.1
      UniProtKB/Swiss-Prot
      P30411
      UniProtKB/TrEMBL
      B4DRL4, Q68DM8
      Related
      ENSP00000450482.1, ENST00000554311.2
      Conserved Domains (1) summary
      cd15381
      Location:58 → 343
      7tmA_BK-2; bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      96204839..96244164
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      90436088..90475413
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30411.2 GenPept UniProtKB/Swiss-Prot:P30411

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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