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    ACTR3B actin related protein 3B [ Homo sapiens (human) ]

    Gene ID: 57180, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ACTR3Bprovided by HGNC
    Official Full Name
    actin related protein 3Bprovided by HGNC
    Primary source
    HGNC:HGNC:17256
    See related
    Ensembl:ENSG00000133627 AllianceGenome:HGNC:17256
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARP11; ARP3BETA
    Summary
    This gene encodes a member of the actin-related proteins (ARP), which form multiprotein complexes and share 35-55% amino acid identity with conventional actin. The protein encoded by this gene may have a regulatory role in the actin cytoskeleton and induce cell-shape change and motility. Pseudogenes of this gene are located on chromosomes 2, 4, 10, 16, 22 and Y. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]
    Expression
    Broad expression in brain (RPKM 3.7), testis (RPKM 1.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ACTR3B in Genome Data Viewer
    Location:
    7q36.1-q36.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (152759752..152855378)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (153933015..154028620)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (152456837..152552463)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26884 Neighboring gene Sharpr-MPRA regulatory region 2063 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26885 Neighboring gene ATP synthase peripheral stalk-membrane subunit b pseudogene 3 Neighboring gene RNA, 7SL, cytoplasmic 845, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr7:152542780-152542923 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:152543205-152543792 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:152543793-152544380 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:152547394-152548593 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:152580535-152581290 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:152591520-152592087 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:152592088-152592654 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:152665473-152666348 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:152666349-152667224 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:152667225-152668099 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:152683335-152684085 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:152685957-152686952 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:152686953-152687946 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:152740735-152741234 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:152744087-152745286 Neighboring gene MPRA-validated peak6860 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:152780188-152781036 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:152781037-152781883 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:152796011-152796512 Neighboring gene small ubiquitin-related modifier 2-like Neighboring gene uncharacterized LOC102723686 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:152887976-152889175 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:152890387-152890887 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:152900290-152901489 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:152955709-152956222 Neighboring gene Sharpr-MPRA regulatory region 3392

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The Arp2/3 complex: a multifunctional actin organizer. Machesky LM, et al. Curr Opin Cell Biol, 1999 Feb. PMID 10047519
    2. Derangement of hypothetical proteins in fetal Down's syndrome brain. Shin JH, et al. Neurochem Res, 2004 Jun. PMID 15176487
    3. ARP3beta, the gene encoding a new human actin-related protein, is alternatively spliced and predominantly expressed in brain neuronal cells. Jay P, et al. Eur J Biochem, 2000 May. PMID 10806390
    4. Isolation of a novel actin-related gene expressed in low-metastatic PC-14 human lung adenocarcinoma. Shindo-Okada N, et al. Biochem Biophys Res Commun, 2001 Jan 12. PMID 11162478
    5. Expression of the Arp11 gene suppresses the tumorigenicity of PC-14 human lung adenocarcinoma cells. Shindo-Okada N, et al. Biochem Biophys Res Commun, 2003 Dec 26. PMID 14651955

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    2. Thus, overexpression of Arp11 may suppress tumorigenicity in nude mice.
      Title: Expression of the Arp11 gene suppresses the tumorigenicity of PC-14 human lung adenocarcinoma cells.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp686O24114

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular exosome HDA PubMed 

    General protein information

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    Preferred Names
    actin-related protein 3B
    Names
    ARP3 actin related protein 3 homolog B
    ARP3-beta
    actin-like protein 3B
    actin-related protein 3-beta
    actin-related protein ARP4
    actin-related protein Arp11

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040135.3 → NP_001035225.1  actin-related protein 3B isoform 2

      See identical proteins and their annotated locations for NP_001035225.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons in the coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
      Source sequence(s)
      AA559050, AB209174, AK294292, BC015207, DN601600
      Consensus CDS
      CCDS34782.1
      UniProtKB/TrEMBL
      Q59FV6
      Related
      ENSP00000367007.3, ENST00000377776.7
      Conserved Domains (1) summary
      cl25542
      Location:2 → 347
      Actin; Actin

    2. NM_001350940.2 → NP_001337869.1  actin-related protein 3B isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), as well as variants 4, 5, and 6, encodes isoform 3.
      Source sequence(s)
      AC072057, AC092180
      Consensus CDS
      CCDS87568.1
      UniProtKB/TrEMBL
      B7Z9W3
      Related
      ENSP00000380452.2, ENST00000397282.2
      Conserved Domains (1) summary
      PTZ00280
      Location:1 → 329
      PTZ00280; Actin-related protein 3; Provisional

    3. NM_001350941.2 → NP_001337870.1  actin-related protein 3B isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 3, 5, and 6, encodes isoform 3.
      Source sequence(s)
      AC072057, AC092180
      Consensus CDS
      CCDS87568.1
      UniProtKB/TrEMBL
      B7Z9W3
      Conserved Domains (1) summary
      PTZ00280
      Location:1 → 329
      PTZ00280; Actin-related protein 3; Provisional

    4. NM_001350942.2 → NP_001337871.1  actin-related protein 3B isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variants 3, 4, and 6, encodes isoform 3.
      Source sequence(s)
      AC072057, AC092180
      Consensus CDS
      CCDS87568.1
      UniProtKB/TrEMBL
      B7Z9W3
      Conserved Domains (1) summary
      PTZ00280
      Location:1 → 329
      PTZ00280; Actin-related protein 3; Provisional

    5. NM_001350943.2 → NP_001337872.1  actin-related protein 3B isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variants 3, 4, and 5, encodes isoform 3.
      Source sequence(s)
      AC072057, AC092180
      Consensus CDS
      CCDS87568.1
      UniProtKB/TrEMBL
      B7Z9W3
      Conserved Domains (1) summary
      PTZ00280
      Location:1 → 329
      PTZ00280; Actin-related protein 3; Provisional

    6. NM_001350944.2 → NP_001337873.1  actin-related protein 3B isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC072057, AC092180
      UniProtKB/TrEMBL
      B4DT29
      Conserved Domains (1) summary
      cl25542
      Location:2 → 375
      Actin

    7. NM_001350945.2 → NP_001337874.1  actin-related protein 3B isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC072057, AC092180
      UniProtKB/TrEMBL
      Q59GD5
      Conserved Domains (1) summary
      PTZ00280
      Location:1 → 288
      PTZ00280; Actin-related protein 3; Provisional

    8. NM_001350946.2 → NP_001337875.1  actin-related protein 3B isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC072057, AC092180
      Conserved Domains (1) summary
      cl25542
      Location:1 → 259
      Actin; Actin

    9. NM_020445.6 → NP_065178.1  actin-related protein 3B isoform 1

      See identical proteins and their annotated locations for NP_065178.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AA559050, AB209174, AK315534, DN601600
      Consensus CDS
      CCDS5934.1
      UniProtKB/Swiss-Prot
      A8MTG1, B4DFW4, Q7Z526, Q96BT2, Q9P1U1
      UniProtKB/TrEMBL
      Q59FV6
      Related
      ENSP00000256001.8, ENST00000256001.13
      Conserved Domains (1) summary
      PTZ00280
      Location:2 → 417
      PTZ00280; Actin-related protein 3; Provisional

    RNA

    1. NR_146946.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC072057, AC092180

    2. NR_146947.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC072057, AC092180

    3. NR_146948.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC072057, AC092180

    4. NR_146949.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC072057, AC092180

    5. NR_146950.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC072057, AC092180

    6. NR_146951.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC072057, AC092180

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      152759752..152855378
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      153933015..154028620
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9P1U1.1 GenPept UniProtKB/Swiss-Prot:Q9P1U1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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