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    CALHM2 calcium homeostasis modulator family member 2 [ Homo sapiens (human) ]

    Gene ID: 51063, updated on 28-Oct-2024

    Summary

    Official Symbol
    CALHM2provided by HGNC
    Official Full Name
    calcium homeostasis modulator family member 2provided by HGNC
    Primary source
    HGNC:HGNC:23493
    See related
    Ensembl:ENSG00000138172 MIM:612235; AllianceGenome:HGNC:23493
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAM26B
    Summary
    Predicted to enable monoatomic cation channel activity. Involved in ATP export and positive regulation of apoptotic process. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 19.8), endometrium (RPKM 13.4) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CALHM2 in Genome Data Viewer
    Location:
    10q24.33
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (103446786..103452370, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (104334092..104339676, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (105206543..105212127, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105155495-105156327 Neighboring gene ATP synthase membrane subunit k Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105156867-105157368 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105157369-105157869 Neighboring gene microRNA 1307 Neighboring gene programmed cell death 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:105211118-105211738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:105211739-105212360 Neighboring gene uncharacterized LOC124902494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3961 Neighboring gene calcium homeostasis modulator 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3962 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3963 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3964 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105235766-105236660 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105236661-105237555 Neighboring gene calcium homeostasis modulator 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables monoatomic cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in ATP export IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in calcium ion import ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of microglial cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of synaptic plasticity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    calcium homeostasis modulator protein 2
    Names
    calcium homeostasis modulator 2
    family with sequence similarity 26, member B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015916.5NP_057000.2  calcium homeostasis modulator protein 2

      See identical proteins and their annotated locations for NP_057000.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein.
      Source sequence(s)
      BC000039, CA432041, DB109582
      Consensus CDS
      CCDS7549.1
      UniProtKB/Swiss-Prot
      D3DR94, O95893, Q6ZUV9, Q9HA72
      Related
      ENSP00000260743.5, ENST00000260743.10
      Conserved Domains (1) summary
      pfam14798
      Location:7256
      Ca_hom_mod; Calcium homeostasis modulator

    RNA

    1. NR_024552.2 RNA Sequence

      Status: VALIDATED

      Description
      This variant (2) contains an alternate 5' splice site, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF131810, CA432041, DB109582
    2. NR_046344.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' splice site, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK022195, BC000039, CA432041

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      103446786..103452370 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017016309.3XP_016871798.1  calcium homeostasis modulator protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q9HA72
      Conserved Domains (1) summary
      pfam14798
      Location:9180
      Ca_hom_mod; Calcium homeostasis modulator
    2. XM_006717883.3XP_006717946.1  calcium homeostasis modulator protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006717946.1

      UniProtKB/Swiss-Prot
      D3DR94, O95893, Q6ZUV9, Q9HA72
      Conserved Domains (1) summary
      pfam14798
      Location:7256
      Ca_hom_mod; Calcium homeostasis modulator
    3. XM_047425280.1XP_047281236.1  calcium homeostasis modulator protein 2 isoform X2

    4. XM_047425271.1XP_047281227.1  calcium homeostasis modulator protein 2 isoform X1

      UniProtKB/Swiss-Prot
      D3DR94, O95893, Q6ZUV9, Q9HA72
    5. XM_047425281.1XP_047281237.1  calcium homeostasis modulator protein 2 isoform X2

    6. XM_017016307.2XP_016871796.1  calcium homeostasis modulator protein 2 isoform X1

      UniProtKB/Swiss-Prot
      D3DR94, O95893, Q6ZUV9, Q9HA72
      Conserved Domains (1) summary
      pfam14798
      Location:7256
      Ca_hom_mod; Calcium homeostasis modulator
    7. XM_006717884.5XP_006717947.1  calcium homeostasis modulator protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006717947.1

      UniProtKB/Swiss-Prot
      Q9HA72
      Conserved Domains (1) summary
      pfam14798
      Location:9180
      Ca_hom_mod; Calcium homeostasis modulator
    8. XM_011539848.3XP_011538150.1  calcium homeostasis modulator protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011538150.1

      UniProtKB/Swiss-Prot
      D3DR94, O95893, Q6ZUV9, Q9HA72
      Conserved Domains (1) summary
      pfam14798
      Location:7256
      Ca_hom_mod; Calcium homeostasis modulator
    9. XM_047425277.1XP_047281233.1  calcium homeostasis modulator protein 2 isoform X2

    10. XM_006717880.3XP_006717943.1  calcium homeostasis modulator protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006717943.1

      UniProtKB/Swiss-Prot
      D3DR94, O95893, Q6ZUV9, Q9HA72
      Related
      ENSP00000358803.3, ENST00000369788.7
      Conserved Domains (1) summary
      pfam14798
      Location:7256
      Ca_hom_mod; Calcium homeostasis modulator
    11. XM_047425282.1XP_047281238.1  calcium homeostasis modulator protein 2 isoform X2

    12. XM_047425272.1XP_047281228.1  calcium homeostasis modulator protein 2 isoform X1

      UniProtKB/Swiss-Prot
      D3DR94, O95893, Q6ZUV9, Q9HA72
    13. XM_047425279.1XP_047281235.1  calcium homeostasis modulator protein 2 isoform X2

    14. XM_047425268.1XP_047281224.1  calcium homeostasis modulator protein 2 isoform X1

      UniProtKB/Swiss-Prot
      D3DR94, O95893, Q6ZUV9, Q9HA72
    15. XM_017016308.3XP_016871797.1  calcium homeostasis modulator protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q9HA72
      Conserved Domains (1) summary
      pfam14798
      Location:9180
      Ca_hom_mod; Calcium homeostasis modulator
    16. XM_017016306.2XP_016871795.1  calcium homeostasis modulator protein 2 isoform X1

      UniProtKB/Swiss-Prot
      D3DR94, O95893, Q6ZUV9, Q9HA72
      Conserved Domains (1) summary
      pfam14798
      Location:7256
      Ca_hom_mod; Calcium homeostasis modulator
    17. XM_024448035.2XP_024303803.1  calcium homeostasis modulator protein 2 isoform X2

    18. XM_024448034.2XP_024303802.1  calcium homeostasis modulator protein 2 isoform X1

      UniProtKB/Swiss-Prot
      D3DR94, O95893, Q6ZUV9, Q9HA72
      Conserved Domains (1) summary
      pfam14798
      Location:7256
      Ca_hom_mod; Calcium homeostasis modulator
    19. XM_047425278.1XP_047281234.1  calcium homeostasis modulator protein 2 isoform X2

    20. XM_047425270.1XP_047281226.1  calcium homeostasis modulator protein 2 isoform X1

      UniProtKB/Swiss-Prot
      D3DR94, O95893, Q6ZUV9, Q9HA72
    21. XM_047425275.1XP_047281231.1  calcium homeostasis modulator protein 2 isoform X2

    22. XM_047425267.1XP_047281223.1  calcium homeostasis modulator protein 2 isoform X1

      UniProtKB/Swiss-Prot
      D3DR94, O95893, Q6ZUV9, Q9HA72
    23. XM_047425274.1XP_047281230.1  calcium homeostasis modulator protein 2 isoform X2

    24. XM_047425265.1XP_047281221.1  calcium homeostasis modulator protein 2 isoform X1

      UniProtKB/Swiss-Prot
      D3DR94, O95893, Q6ZUV9, Q9HA72
    25. XM_047425269.1XP_047281225.1  calcium homeostasis modulator protein 2 isoform X1

      UniProtKB/Swiss-Prot
      D3DR94, O95893, Q6ZUV9, Q9HA72
    26. XM_047425266.1XP_047281222.1  calcium homeostasis modulator protein 2 isoform X1

      UniProtKB/Swiss-Prot
      D3DR94, O95893, Q6ZUV9, Q9HA72
    27. XM_047425276.1XP_047281232.1  calcium homeostasis modulator protein 2 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      104334092..104339676 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366003.1XP_054221978.1  calcium homeostasis modulator protein 2 isoform X2

    2. XM_054365990.1XP_054221965.1  calcium homeostasis modulator protein 2 isoform X1

      UniProtKB/Swiss-Prot
      D3DR94, O95893, Q6ZUV9, Q9HA72
    3. XM_054366000.1XP_054221975.1  calcium homeostasis modulator protein 2 isoform X2

    4. XM_054365987.1XP_054221962.1  calcium homeostasis modulator protein 2 isoform X1

      UniProtKB/Swiss-Prot
      D3DR94, O95893, Q6ZUV9, Q9HA72
    5. XM_054366001.1XP_054221976.1  calcium homeostasis modulator protein 2 isoform X2

    6. XM_054365988.1XP_054221963.1  calcium homeostasis modulator protein 2 isoform X1

      UniProtKB/Swiss-Prot
      D3DR94, O95893, Q6ZUV9, Q9HA72
    7. XM_054365997.1XP_054221972.1  calcium homeostasis modulator protein 2 isoform X2

    8. XM_054365982.1XP_054221957.1  calcium homeostasis modulator protein 2 isoform X1

      UniProtKB/Swiss-Prot
      D3DR94, O95893, Q6ZUV9, Q9HA72
    9. XM_054365996.1XP_054221971.1  calcium homeostasis modulator protein 2 isoform X2

    10. XM_054365981.1XP_054221956.1  calcium homeostasis modulator protein 2 isoform X1

      UniProtKB/Swiss-Prot
      D3DR94, O95893, Q6ZUV9, Q9HA72
    11. XM_054366002.1XP_054221977.1  calcium homeostasis modulator protein 2 isoform X2

    12. XM_054365989.1XP_054221964.1  calcium homeostasis modulator protein 2 isoform X1

      UniProtKB/Swiss-Prot
      D3DR94, O95893, Q6ZUV9, Q9HA72
    13. XM_054365999.1XP_054221974.1  calcium homeostasis modulator protein 2 isoform X2

    14. XM_054365984.1XP_054221959.1  calcium homeostasis modulator protein 2 isoform X1

      UniProtKB/Swiss-Prot
      D3DR94, O95893, Q6ZUV9, Q9HA72
    15. XM_054365991.1XP_054221966.1  calcium homeostasis modulator protein 2 isoform X2

    16. XM_054365983.1XP_054221958.1  calcium homeostasis modulator protein 2 isoform X1

      UniProtKB/Swiss-Prot
      D3DR94, O95893, Q6ZUV9, Q9HA72
    17. XM_054365993.1XP_054221968.1  calcium homeostasis modulator protein 2 isoform X2

    18. XM_054365978.1XP_054221953.1  calcium homeostasis modulator protein 2 isoform X1

      UniProtKB/Swiss-Prot
      D3DR94, O95893, Q6ZUV9, Q9HA72
    19. XM_054365998.1XP_054221973.1  calcium homeostasis modulator protein 2 isoform X2

    20. XM_054365986.1XP_054221961.1  calcium homeostasis modulator protein 2 isoform X1

      UniProtKB/Swiss-Prot
      D3DR94, O95893, Q6ZUV9, Q9HA72
    21. XM_054365994.1XP_054221969.1  calcium homeostasis modulator protein 2 isoform X2

    22. XM_054365980.1XP_054221955.1  calcium homeostasis modulator protein 2 isoform X1

      UniProtKB/Swiss-Prot
      D3DR94, O95893, Q6ZUV9, Q9HA72
    23. XM_054365992.1XP_054221967.1  calcium homeostasis modulator protein 2 isoform X2

    24. XM_054365977.1XP_054221952.1  calcium homeostasis modulator protein 2 isoform X1

      UniProtKB/Swiss-Prot
      D3DR94, O95893, Q6ZUV9, Q9HA72
    25. XM_054365985.1XP_054221960.1  calcium homeostasis modulator protein 2 isoform X1

      UniProtKB/Swiss-Prot
      D3DR94, O95893, Q6ZUV9, Q9HA72
    26. XM_054365979.1XP_054221954.1  calcium homeostasis modulator protein 2 isoform X1

      UniProtKB/Swiss-Prot
      D3DR94, O95893, Q6ZUV9, Q9HA72
    27. XM_054365995.1XP_054221970.1  calcium homeostasis modulator protein 2 isoform X2