Fdps farnesyl diphosphate synthase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fdpsprovided by RGD
Official Full Name: farnesyl diphosphate synthaseprovided by RGD
Primary source: RGD:68953
See related: EnsemblRapid:ENSRNOG00000077379 AllianceGenome:RGD:68953
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: FPS; Ac2-125
Summary: Enables geranyltranstransferase activity. Involved in several processes, including farnesyl diphosphate biosynthetic process; positive regulation of cell growth involved in cardiac muscle cell development; and positive regulation of cholesterol biosynthetic process. Located in mitochondrial matrix and peroxisome. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human FDPS (farnesyl diphosphate synthase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 2270.4), Testes (RPKM 609.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (176795192..176804816, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (174497402..174507031, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (188403595..188413219, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data indicate that FPPS may play an important role in Ang II-induced fibrotic responses in VSMCs
Title: Inhibition of farnesyl pyrophosphate synthase attenuates angiotensin II-induced fibrotic responses in vascular smooth muscle cells.
Inhibition of farnesyl pyrophosphate synthase prevents angiotensin II-induced cardiac fibrosis in vitro.
Title: Inhibition of farnesyl pyrophosphate synthase prevents angiotensin II-induced cardiac fibrosis in vitro.
This is the first report to show that chronic inhibition of farnesyl pyrophosphate synthase attenuates the development of cardiac hypertrophy and fibrosis.
Title: Chronic inhibition of farnesyl pyrophosphate synthase attenuates cardiac hypertrophy and fibrosis in spontaneously hypertensive rats.
inhibition of FPP synthase by alendronate reduces RhoA activation by diminishing geranylgeranylation which prevents Ang II-induced hypertrophic responses in neonatal cardiomyocytes.
Title: Inhibition of farnesylpyrophosphate synthase prevents angiotensin II-induced hypertrophic responses in rat neonatal cardiomyocytes: involvement of the RhoA/Rho kinase pathway.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW534365 (e-PCR)
- UniSTS:246568

RH127967 (e-PCR)
- UniSTS:211277

RH128237 (e-PCR)
- UniSTS:211545

AA408288 (e-PCR)
- UniSTS:159138

D2Arb36 (e-PCR)
- UniSTS:240572

BQ193911 (e-PCR)
- UniSTS:261858

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables dimethylallyltranstransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables geranyltranstransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables geranyltranstransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables geranyltranstransferase activity	TAS Traceable Author Statement more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables prenyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to fatty acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in cholesterol biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in farnesyl diphosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in farnesyl diphosphate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in farnesyl diphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in geranyl diphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in isoprenoid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of cell growth involved in cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cholesterol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to cholesterol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to testosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: farnesyl pyrophosphate synthase

Names: (2E,6E)-farnesyl diphosphate synthase; CR 39; FPP synthase; FPP synthetase; cholesterol-regulated 39 kDa protein; dimethylallyltranstransferase; farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase); farnesyl diphosphate synthetase; farnesyl pyrophosphate synthetase; geranyltranstransferase; testis-specific farnesyl pyrophosphate synthetase

NP_114028.1

EC 2.5.1.1

EC 2.5.1.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.