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    Zfp653 zinc finger protein 653 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300446, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zfp653provided by RGD
    Official Full Name
    zinc finger protein 653provided by RGD
    Primary source
    RGD:1308754
    See related
    EnsemblRapid:ENSRNOG00000014065 AllianceGenome:RGD:1308754
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308754
    Summary
    Predicted to enable AF-2 domain binding activity; DNA-binding transcription factor binding activity; and transcription corepressor activity. Predicted to be involved in extracellular negative regulation of signal transduction and negative regulation of transcription by RNA polymerase II. Predicted to be located in extracellular region. Predicted to be active in nucleus. Orthologous to human ZNF653 (zinc finger protein 653). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 72.1), Thymus (RPKM 40.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp653 in Genome Data Viewer
    Location:
    8q13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (28862618..28881439, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (20586607..20605439, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (23066576..23085502, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene PRKCSH beta subunit of glucosidase II Neighboring gene ELAV like RNA binding protein 3 Neighboring gene uncharacterized LOC120094091 Neighboring gene ECSIT signaling integrator Neighboring gene calponin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a novel zinc finger protein that modulates the transcriptional activity of nuclear receptors. Borud B, et al. Mol Endocrinol, 2003 Nov. PMID 12920234
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables AF-2 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in extracellular negative regulation of signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 653

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106807.2 → NP_001100277.1  zinc finger protein 653 isoform 2

      See identical proteins and their annotated locations for NP_001100277.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6JNX7
      Conserved Domains (3) summary
      COG5048
      Location:486 → 614
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:503 → 522
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:514 → 539
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001413474.1 → NP_001400403.1  zinc finger protein 653 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      D3ZM61
      Related
      ENSRNOP00000018874.7, ENSRNOT00000018874.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      28862618..28881439 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081010.2 → XP_038936938.1  zinc finger protein 653 isoform X1

    2. XM_063265068.1 → XP_063121138.1  zinc finger protein 653 isoform X4

    3. XM_039081011.2 → XP_038936939.1  zinc finger protein 653 isoform X2

    4. XM_063265067.1 → XP_063121137.1  zinc finger protein 653 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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