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    TMEM62 transmembrane protein 62 [ Homo sapiens (human) ]

    Gene ID: 80021, updated on 3-Apr-2024

    Summary

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    Official Symbol
    TMEM62provided by HGNC
    Official Full Name
    transmembrane protein 62provided by HGNC
    Primary source
    HGNC:HGNC:26269
    See related
    Ensembl:ENSG00000137842 AllianceGenome:HGNC:26269
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable hydrolase activity. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in colon (RPKM 6.4), duodenum (RPKM 6.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TMEM62 in Genome Data Viewer
    Location:
    15q15.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (43133115..43185144)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (40940411..40992433)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (43425313..43477342)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene RPS3A pseudogene 47 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6381 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6382 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:43426442-43426653 Neighboring gene signal peptidase complex subunit 2 pseudogene 1 Neighboring gene farnesyl diphosphate synthase pseudogene 10 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:43459413-43460109 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:43467716-43468216 Neighboring gene uncharacterized LOC124903478 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6383 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6384 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9310 Neighboring gene cyclin D1 binding protein 1 Neighboring gene Sharpr-MPRA regulatory region 15360 Neighboring gene erythrocyte membrane protein band 4.2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Arachidonic acid metabolism in the human placenta: identification of a putative lipoxygenase. Jadoon A, et al. Placenta, 2014 Jun. PMID 24767823
    2. Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1. Dgany O, et al. Am J Hum Genet, 2002 Dec. PMID 12434312, Free PMC Article
    3. Systematic protein-protein interaction mapping for clinically relevant human GPCRs. Sokolina K, et al. Mol Syst Biol, 2017 Mar 15. PMID 28298427, Free PMC Article
    4. A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U, et al. Cell, 2005 Sep 23. PMID 16169070
    5. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. Maruyama K, et al. Gene, 1994 Jan 28. PMID 8125298

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ23375

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 62

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347004.1 → NP_001333933.1  transmembrane protein 62 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2), as well as variants 3-5, encodes isoform b.
      Source sequence(s)
      AC068724
      UniProtKB/TrEMBL
      H3BVF7

    2. NM_001347005.2 → NP_001333934.1  transmembrane protein 62 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variants 2, 4, and 5, encodes isoform b.
      Source sequence(s)
      AC068724
      UniProtKB/TrEMBL
      H3BVF7

    3. NM_001347006.2 → NP_001333935.1  transmembrane protein 62 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variants 2, 3, and 5, encodes isoform b.
      Source sequence(s)
      AC068724
      UniProtKB/TrEMBL
      H3BVF7

    4. NM_001347007.2 → NP_001333936.1  transmembrane protein 62 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 2-4, encodes isoform b.
      Source sequence(s)
      AC068724
      UniProtKB/TrEMBL
      H3BVF7

    5. NM_001347008.1 → NP_001333937.1  transmembrane protein 62 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 7-11, encodes isoform c.
      Source sequence(s)
      AC068724
      UniProtKB/TrEMBL
      H3BVF7

    6. NM_001347009.1 → NP_001333938.1  transmembrane protein 62 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variants 6 and 8-11, encodes isoform c.
      Source sequence(s)
      AC068724
      UniProtKB/TrEMBL
      H3BVF7

    7. NM_001347010.2 → NP_001333939.1  transmembrane protein 62 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variants 6-7 and 9-11, encodes isoform c.
      Source sequence(s)
      AC068724
      UniProtKB/TrEMBL
      H3BVF7

    8. NM_001347011.2 → NP_001333940.1  transmembrane protein 62 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9), as well as variants 6-8 and 10-11, encodes isoform c.
      Source sequence(s)
      AC068724
      UniProtKB/TrEMBL
      H3BVF7

    9. NM_001347012.2 → NP_001333941.1  transmembrane protein 62 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variants 6-9 and 11, encodes isoform c.
      Source sequence(s)
      AC068724
      UniProtKB/TrEMBL
      H3BVF7

    10. NM_001347013.2 → NP_001333942.1  transmembrane protein 62 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11), as well as variants 6-10, encodes isoform c.
      Source sequence(s)
      AC068724
      UniProtKB/TrEMBL
      H3BVF7

    11. NM_001347014.1 → NP_001333943.1  transmembrane protein 62 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12), as well as variants 13 and 14, encodes isoform d.
      Source sequence(s)
      AC068724
      UniProtKB/TrEMBL
      H3BVF7

    12. NM_001347015.2 → NP_001333944.1  transmembrane protein 62 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13), as well as variants 12 and 14, encodes isoform d.
      Source sequence(s)
      AC068724
      UniProtKB/TrEMBL
      H3BVF7

    13. NM_001347016.2 → NP_001333945.1  transmembrane protein 62 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14), as well as variants 12 and 13, encodes isoform d.
      Source sequence(s)
      AC068724
      UniProtKB/TrEMBL
      H3BVF7

    14. NM_001347017.2 → NP_001333946.1  transmembrane protein 62 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15), as well as variant 16, encodes isoform e.
      Source sequence(s)
      AC068724
      UniProtKB/TrEMBL
      H3BVF7

    15. NM_001347018.2 → NP_001333947.1  transmembrane protein 62 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16), as well as variant 15, encodes isoform e.
      Source sequence(s)
      AC068724
      UniProtKB/TrEMBL
      H3BVF7

    16. NM_001347019.1 → NP_001333948.1  transmembrane protein 62 isoform f

      Status: VALIDATED

      Description
      Transcript Variant: This variant (17), as well as variants 18-20, encodes isoform f.
      Source sequence(s)
      AC068724

    17. NM_001347020.2 → NP_001333949.1  transmembrane protein 62 isoform f

      Status: VALIDATED

      Description
      Transcript Variant: This variant (18), as well as variants 17 and 19-20, encodes isoform f.
      Source sequence(s)
      AC068724

    18. NM_001347021.2 → NP_001333950.1  transmembrane protein 62 isoform f

      Status: VALIDATED

      Description
      Transcript Variant: This variant (19), as well as variants 17-18 and 20, encodes isoform f.
      Source sequence(s)
      AC068724

    19. NM_001347023.2 → NP_001333952.1  transmembrane protein 62 isoform f

      Status: VALIDATED

      Description
      Transcript Variant: This variant (20), as well as variants 17-19, encodes isoform f.
      Source sequence(s)
      AC068724

    20. NM_001347024.1 → NP_001333953.1  transmembrane protein 62 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (21), as well as variants 22-26, encodes isoform g.
      Source sequence(s)
      AC068724

    21. NM_001347025.1 → NP_001333954.1  transmembrane protein 62 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (22), as well as variants 21 and 23-26, encodes isoform g.
      Source sequence(s)
      AC068724

    22. NM_001347026.2 → NP_001333955.1  transmembrane protein 62 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (23), as well as variants 21-22 and 24-26, encodes isoform g.
      Source sequence(s)
      AC068724

    23. NM_001347027.2 → NP_001333956.1  transmembrane protein 62 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (24), as well as variants 21-23 and 25-26, encodes isoform g.
      Source sequence(s)
      AC068724

    24. NM_001347028.2 → NP_001333957.1  transmembrane protein 62 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (25), as well as variants 21-24 and 26, encodes isoform g.
      Source sequence(s)
      AC068724

    25. NM_001347029.2 → NP_001333958.1  transmembrane protein 62 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (26), as well as variants 21-25, encodes isoform g.
      Source sequence(s)
      AC068724

    26. NM_001347030.1 → NP_001333959.1  transmembrane protein 62 isoform h

      Status: VALIDATED

      Source sequence(s)
      AC068724

    27. NM_001347031.2 → NP_001333960.1  transmembrane protein 62 isoform i

      Status: VALIDATED

      Source sequence(s)
      AC068724
      UniProtKB/TrEMBL
      H3BVF7

    28. NM_001347032.2 → NP_001333961.1  transmembrane protein 62 isoform j

      Status: VALIDATED

      Source sequence(s)
      AC068724
      UniProtKB/TrEMBL
      H3BVF7
      Related
      ENSP00000458098.1, ENST00000564494.1

    29. NM_001347033.2 → NP_001333962.1  transmembrane protein 62 isoform k

      Status: VALIDATED

      Source sequence(s)
      AC068724
      UniProtKB/TrEMBL
      H3BVF7

    30. NM_001347034.2 → NP_001333963.1  transmembrane protein 62 isoform l

      Status: VALIDATED

      Source sequence(s)
      AC068724

    31. NM_024956.4 → NP_079232.3  transmembrane protein 62 isoform a

      See identical proteins and their annotated locations for NP_079232.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      BC009981
      Consensus CDS
      CCDS32210.1
      UniProtKB/Swiss-Prot
      Q0P6H9, Q6I9Y5, Q9H5J6
      UniProtKB/TrEMBL
      H3BVF7
      Related
      ENSP00000260403.2, ENST00000260403.7
      Conserved Domains (3) summary
      cd07401
      Location:57 → 345
      MPP_TMEM62_N; Homo sapiens TMEM62, N-terminal metallophosphatase domain
      pfam00149
      Location:59 → 259
      Metallophos; Calcineurin-like phosphoesterase
      pfam13754
      Location:351 → 409
      Big_3_4; Bacterial Ig-like domain (group 3)

    RNA

    1. NR_144541.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC068724

    2. NR_144542.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC068724

    3. NR_144543.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC068724

    4. NR_144544.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC068724

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      43133115..43185144
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047433103.1 → XP_047289059.1  transmembrane protein 62 isoform X3

    2. XM_047433101.1 → XP_047289057.1  transmembrane protein 62 isoform X1

    3. XM_047433102.1 → XP_047289058.1  transmembrane protein 62 isoform X2

    4. XM_024450071.2 → XP_024305839.1  transmembrane protein 62 isoform X6

      Conserved Domains (1) summary
      cl13995
      Location:92 → 126
      MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain

    5. XM_024450072.2 → XP_024305840.1  transmembrane protein 62 isoform X7

      Conserved Domains (1) summary
      cd07401
      Location:57 → 341
      MPP_TMEM62_N; Homo sapiens TMEM62, N-terminal metallophosphatase domain

    6. XM_047433104.1 → XP_047289060.1  transmembrane protein 62 isoform X4

    7. XM_047433105.1 → XP_047289061.1  transmembrane protein 62 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      40940411..40992433
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054378895.1 → XP_054234870.1  transmembrane protein 62 isoform X3

    2. XM_054378898.1 → XP_054234873.1  transmembrane protein 62 isoform X6

    3. XM_054378899.1 → XP_054234874.1  transmembrane protein 62 isoform X7

    4. XM_054378896.1 → XP_054234871.1  transmembrane protein 62 isoform X4

    5. XM_054378897.1 → XP_054234872.1  transmembrane protein 62 isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0P6H9.1 GenPept UniProtKB/Swiss-Prot:Q0P6H9

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