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    Ctbs chitobiase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81652, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Ctbsprovided by RGD
    Official Full Name
    chitobiaseprovided by RGD
    Primary source
    RGD:621338
    See related
    EnsemblRapid:ENSRNOG00000015573 AllianceGenome:RGD:621338
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables chitinase activity. Involved in chitin catabolic process and oligosaccharide catabolic process. Predicted to be located in lysosome. Orthologous to human CTBS (chitobiase). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Liver (RPKM 386.4), Thymus (RPKM 265.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ctbs in Genome Data Viewer
    Location:
    2q44
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (238000800..238015368)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (235340520..235355091)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (252305874..252320387)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 777 Neighboring gene SSX family member 2 interacting protein Neighboring gene spermatogenesis associated 1 Neighboring gene uncharacterized LOC134485993 Neighboring gene G protein subunit gamma 5 Neighboring gene ribosome production factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rat liver chitobiase: purification, properties, and role in the lysosomal degradation of Asn-linked glycoproteins. Aronson NN Jr, et al. Arch Biochem Biophys, 1989 Aug 1. PMID 2751306
    2. Cloning and expression of the cDNA sequence encoding the lysosomal glycosidase di-N-acetylchitobiase. Fisher KJ, et al. J Biol Chem, 1992 Sep 25. PMID 1527079
    3. New paralogues and revised time line in the expansion of the vertebrate GH18 family. Hussain M, et al. J Mol Evol, 2013 Apr. PMID 23558346
    4. Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Palmer DJ, et al. Proteomics, 2006 Apr. PMID 16502470
    5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity, acting on glycosyl bonds TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chitin catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chitin catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in oligosaccharide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oligosaccharide catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    di-N-acetylchitobiase
    Names
    chitobiase, di-N-acetyl-
    NP_112285.1
    XP_038959139.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031023.1 → NP_112285.1  di-N-acetylchitobiase precursor

      See identical proteins and their annotated locations for NP_112285.1

      Status: PROVISIONAL

      Source sequence(s)
      M95768
      UniProtKB/Swiss-Prot
      Q01460
      UniProtKB/TrEMBL
      A6HWD6, A6HWD7
      Related
      ENSRNOP00000020972.2, ENSRNOT00000020972.6
      Conserved Domains (2) summary
      cd02875
      Location:23 → 363
      GH18_chitobiase; Chitobiase (also known as di-N-acetylchitobiase) is a lysosomal glycosidase that hydrolyzes the reducing-end N-acetylglucosamine from the chitobiose core of oligosaccharides during the ordered degradation of asparagine-linked glycoproteins in eukaryotes. ...
      smart00636
      Location:100 → 343
      Glyco_18; Glyco_18 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      238000800..238015368
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103211.2 → XP_038959139.1  di-N-acetylchitobiase isoform X1

      Conserved Domains (1) summary
      cl10447
      Location:43 → 247
      GH18_chitinase-like; The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q01460.1 GenPept UniProtKB/Swiss-Prot:Q01460

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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