Npvf neuropeptide VF precursor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Npvfprovided by RGD
Official Full Name: neuropeptide VF precursorprovided by RGD
Primary source: RGD:61815
See related: EnsemblRapid:ENSRNOG00000010806 AllianceGenome:RGD:61815
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rfrp
Summary: Enables signaling receptor binding activity. Involved in neuropeptide signaling pathway and sensory perception of pain. Predicted to be located in extracellular region. Orthologous to human NPVF (neuropeptide VF precursor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 10.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 4q24

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (81043128..81047045, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (79712358..79716275, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (80391785..80395476, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gene expression pattern of Kisspeptin and RFamide-related peptide (Rfrp) in the male Damaraland mole-rat hypothalamus.
Title: Gene expression pattern of Kisspeptin and RFamide-related peptide (Rfrp) in the male Damaraland mole-rat hypothalamus.
Chronic stress has long-term effects on pregnancy success, even post-stressor, that are mediated by RFRP3.[RFRP3]
Title: Knockdown of hypothalamic RFRP3 prevents chronic stress-induced infertility and embryo resorption.
RFRP-3, the Mammalian Ortholog of GnIH, Is a Novel Modulator Involved in Food Intake and Glucose Homeostasis.
Title: RFRP-3, the Mammalian Ortholog of GnIH, Is a Novel Modulator Involved in Food Intake and Glucose Homeostasis.
role in modulating ovarian physiology in response to sympathetic stress
Title: Role of RFRP-3 in the development of cold stress-induced polycystic ovary phenotype in rats.
study concluded that RFamide-related peptide- (3RFRP-3) plays a regulatory role in male rat reproduction
Title: Effect of RFRP-3, the mammalian ortholog of GnIH, on the epididymis of male rats.
Rfrp (GnIH)-expressing neurons serve as potential upstream mediators of stress-induced effects through Gpr147 (GnIH-R)-dependent mechanisms.
Title: Glucocorticoid receptor-mediated regulation of Rfrp (GnIH) and Gpr147 (GnIH-R) synthesis in immortalized hypothalamic neurons.
Hypothalamic expression of Rfrp and Rfrp1r receptor in rats peaks during the pubertal period in males (postnatal day (PND)-35 to PND-42) but not in females
Title: Physiological roles of gonadotropin-inhibitory hormone signaling in the control of mammalian reproductive axis: studies in the NPFF1 receptor null mouse.
Both acute and chronic immobilization stress lead to an up-regulation of RFRP expression in the dorsomedial hypothalamus (DMH) of adult male rats.
Title: Stress increases putative gonadotropin inhibitory hormone and decreases luteinizing hormone in male rats.
The hypothalamic RFRP system changes during development. Ovarian sex steroid estradiol-17beta (E2) may stimulate mRNA expression of RFRP in the prepubertal period when the basal E2 concentration is low.
Title: Developmental changes in the mammalian gonadotropin-inhibitory hormone (GnIH) ortholog RFamide-related peptide (RFRP) and its cognate receptor GPR147 in the rat hypothalamus.
RFRP-3 inhibits secretion of LH and FSH inmammals.
Title: Characterization of the inhibitory roles of RFRP3, the mammalian ortholog of GnIH, in the control of gonadotropin secretion in the rat: in vivo and in vitro studies.

Submit: New GeneRIF Correction See all GeneRIFs (15)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables neuropeptide activity	IEA Inferred from Electronic Annotation more info
NOT enables neuropeptide activity	ISO Inferred from Sequence Orthology more info
enables neuropeptide activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of gonadotropin secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of gonadotropin secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gonadotropin secretion	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pro-FMRFamide-related neuropeptide VF

Names: FMRFamide-related peptides; RFamide-related peptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023952.2 → NP_076442.2 pro-FMRFamide-related neuropeptide VF precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

Q920A3, Q9ESQ9

UniProtKB/TrEMBL

A6K0M5, G3V7F7

Related

ENSRNOP00000014437.4, ENSRNOT00000014437.6