Arhgap6 Rho GTPase activating protein 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arhgap6provided by RGD
Official Full Name: Rho GTPase activating protein 6provided by RGD
Primary source: RGD:2323364
See related: EnsemblRapid:ENSRNOG00000003956 AllianceGenome:RGD:2323364
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GTPase activator activity; phospholipase activator activity; and phospholipase binding activity. Predicted to be involved in several processes, including focal adhesion assembly; negative regulation of cellular component organization; and positive regulation of hydrolase activity. Predicted to be located in actin cytoskeleton and cytosol. Orthologous to human ARHGAP6 (Rho GTPase activating protein 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 65.9), Spleen (RPKM 39.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq13

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (28525912..29062344, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (24953464..25490003, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (26314561..26845242, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

px-44e9 (e-PCR)
- UniSTS:257819

G45234 (e-PCR)
- UniSTS:106036

AU047040 (e-PCR)
- UniSTS:110901

DXMgh8 (e-PCR)
- UniSTS:119620

DXGot19 (e-PCR)
- UniSTS:112204

DXRat9 (e-PCR)
- UniSTS:119633

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables phospholipase activator activity	ISO Inferred from Sequence Orthology more info
enables phospholipase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in focal adhesion assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phospholipase activity	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rho GTPase-activating protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427045.1 → NP_001413974.1 rho GTPase-activating protein 6

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A0A8I5ZJJ6

Related

ENSRNOP00000077649.1, ENSRNOT00000115148.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

28525912..29062344 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017602284.3 → XP_017457773.1 rho GTPase-activating protein 6 isoform X1

UniProtKB/TrEMBL

A0A8I6AAE4

Related

ENSRNOP00000090594.1, ENSRNOT00000118335.2
XM_063279695.1 → XP_063135765.1 rho GTPase-activating protein 6 isoform X6
XM_039100295.2 → XP_038956223.1 rho GTPase-activating protein 6 isoform X3

UniProtKB/TrEMBL

A0A8I6AUK7, D4A5T6

Related

ENSRNOP00000096072.1, ENSRNOT00000111745.2

Conserved Domains (1) summary

cd04376
Location:211 → 417

RhoGAP_ARHGAP6; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS) ...
XM_008773149.3 → XP_008771371.1 rho GTPase-activating protein 6 isoform X4

UniProtKB/TrEMBL

D4A5T6

Conserved Domains (1) summary

cd04376
Location:199 → 405

RhoGAP_ARHGAP6; RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin ...
XM_039100294.2 → XP_038956222.1 rho GTPase-activating protein 6 isoform X2

Conserved Domains (1) summary

cd04376
Location:401 → 607

RhoGAP_ARHGAP6; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS) ...
XM_039100296.2 → XP_038956224.1 rho GTPase-activating protein 6 isoform X5

Conserved Domains (1) summary

cd04376
Location:401 → 607

RhoGAP_ARHGAP6; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS) ...