Rgs10 regulator of G-protein signaling 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rgs10provided by RGD
Official Full Name: regulator of G-protein signaling 10provided by RGD
Primary source: RGD:3562
See related: EnsemblRapid:ENSRNOG00000042592 AllianceGenome:RGD:3562
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable G-protein alpha-subunit binding activity and GTPase activator activity. Involved in response to amphetamine. Located in axon terminus; dendritic spine; and neuronal cell body. Biomarker of opioid abuse. Orthologous to human RGS10 (regulator of G protein signaling 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 606.0), Spleen (RPKM 266.7) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q37

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (192376772..192422640, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (182946334..182987729, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (199782076..199823440, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Endogenous RGS10 has GTPase-activating protein (GAP) activity on the G-protein species that mediates activation of atrial GIRK channels.
Title: A role for RGS10 in beta-adrenergic modulation of G-protein-activated K+ (GIRK) channel current in rat atrial myocytes.
RGS10 modulates pre- and postsynaptic G-protein signaling. Moreover, enrichment of RGS10 in transcriptionally active regions of the nucleus suggests an unforeseen role of RGS10 in modulating gene expression.
Title: Regional, cellular, and subcellular localization of RGS10 in rodent brain.
cell surface expression and regulation of GnRHR bearing a carboxyl-terminus is altered by RGS10, but not by RGS3, proteins
Title: Regulation of the gonadotropin-releasing hormone receptor (GnRHR) by RGS proteins: role of the GnRHR carboxyl-terminus.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G-protein alpha-subunit binding	IEA Inferred from Electronic Annotation more info
enables G-protein alpha-subunit binding	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables GTPase activator activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled acetylcholine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled acetylcholine receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in response to amphetamine	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: regulator of G-protein signaling 10

Names: regulator of G-protein signalling 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019337.1 → NP_062210.1 regulator of G-protein signaling 10

Status: VALIDATED

Source sequence(s)

AI453900, CD372843

UniProtKB/TrEMBL

A0A8I5ZZL9

Related

ENSRNOP00000027375.4, ENSRNOT00000027375.7

Conserved Domains (1) summary

cd08741
Location:42 → 154

RGS_RGS10; Regulator of G protein signaling (RGS) domain found in the RGS10 protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

192376772..192422640 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006230326.5 → XP_006230388.1 regulator of G-protein signaling 10 isoform X3

UniProtKB/TrEMBL

A6IA02

Conserved Domains (1) summary

cl02565
Location:42 → 133

RGS; Regulator of G protein signaling (RGS) domain superfamily
XM_006230325.5 → XP_006230387.1 regulator of G-protein signaling 10 isoform X2

UniProtKB/TrEMBL

A0A8I5ZZL9, A0A8I6A7A9

Related

ENSRNOP00000087056.1, ENSRNOT00000117000.2

Conserved Domains (1) summary

cd08741
Location:28 → 140

RGS_RGS10; Regulator of G protein signaling (RGS) domain found in the RGS10 protein
XM_039088606.2 → XP_038944534.1 regulator of G-protein signaling 10 isoform X1

UniProtKB/TrEMBL

A0A8I5ZZL9

Related

ENSRNOP00000111190.1, ENSRNOT00000137492.1

Conserved Domains (1) summary

cd08741
Location:39 → 151

RGS_RGS10; Regulator of G protein signaling (RGS) domain found in the RGS10 protein
XM_063271970.1 → XP_063128040.1 regulator of G-protein signaling 10 isoform X4