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    Spink4 serine peptidase inhibitor, Kazal type 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 408233, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Spink4provided by RGD
    Official Full Name
    serine peptidase inhibitor, Kazal type 4provided by RGD
    Primary source
    RGD:1303188
    See related
    EnsemblRapid:ENSRNOG00000008252 AllianceGenome:RGD:1303188
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PEC-60
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Involved in response to xenobiotic stimulus. Predicted to be located in extracellular space. Orthologous to human SPINK4 (serine peptidase inhibitor Kazal type 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 7.2), Adrenal (RPKM 6.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Spink4 in Genome Data Viewer
    Location:
    5q22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (60811899..60860823)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (56043936..56064841)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (57238221..57252654)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene beta-1,4-galactosyltransferase 1 Neighboring gene uncharacterized LOC134486929 Neighboring gene BAG cochaperone 1 Neighboring gene charged multivesicular body protein 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Reserpine treatment increases PEC-60-like immunoreactivity in the substantia nigra of the male rat as determined by radioimmunoassay. Fuxe K, et al. Acta Physiol Scand, 1991 Nov. PMID 1772043
    2. A genomic analysis of rat proteases and protease inhibitors. Puente XS, et al. Genome Res, 2004 Apr. PMID 15060002, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine protease inhibitor Kazal-type 4
    Names
    Kazal type serine protease inhibitor 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395750.1 → NP_001382679.1  serine protease inhibitor Kazal-type 4 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6IIS7, E9PU35, Q6IE48
      Related
      ENSRNOP00000057444.3, ENSRNOT00000060714.4
      Conserved Domains (1) summary
      cl00097
      Location:46 → 86
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

    RNA

    1. NR_172724.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      60811899..60860823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288151.1 → XP_063144221.1  serine protease inhibitor Kazal-type 4 isoform X2

    2. XM_063288150.1 → XP_063144220.1  serine protease inhibitor Kazal-type 4 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001008871.1: Suppressed sequence

      Description
      NM_001008871.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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