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    KANK2 KN motif and ankyrin repeat domains 2 [ Homo sapiens (human) ]

    Gene ID: 25959, updated on 3-Nov-2024

    Summary

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    Official Symbol
    KANK2provided by HGNC
    Official Full Name
    KN motif and ankyrin repeat domains 2provided by HGNC
    Primary source
    HGNC:HGNC:29300
    See related
    Ensembl:ENSG00000197256 MIM:614610; AllianceGenome:HGNC:29300
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SIP; MXRA3; PPKWH; NPHS16; ANKRD25
    Summary
    This gene encodes a member of the KN motif and ankyrin repeat domains (KANK) family of proteins, which play a role in cytoskeletal formation by regulating actin polymerization. The encoded protein functions in the sequestration of steroid receptor coactivators and possibly other proteins. Mutations in this gene are associated with impaired kidney podocyte function and nephrotic syndrome, and keratoderma and woolly hair. [provided by RefSeq, Jul 2016]
    Expression
    Ubiquitous expression in endometrium (RPKM 77.8), ovary (RPKM 51.9) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See KANK2 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (11164270..11197865, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (11291296..11324866, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11274946..11308541, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor Neighboring gene microRNA 6886 Neighboring gene VISTA enhancer hs1754 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10101 Neighboring gene SPC24 component of NDC80 kinetochore complex Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11276922-11277422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11300095-11300596 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11300597-11301096 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10102 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10103 Neighboring gene DOCK6 antisense RNA 1 Neighboring gene dedicator of cytokinesis 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11347000-11347810 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11347811-11348621 Neighboring gene angiopoietin like 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nephrotic-syndrome-associated mutation of KANK2 induces pathologic binding competition with physiological interactor KIF21A.
      Title: Nephrotic-syndrome-associated mutation of KANK2 induces pathologic binding competition with physiological interactor KIF21A.
    2. Talin2 and KANK2 functionally interact to regulate microtubule dynamics, paclitaxel sensitivity and cell migration in the MDA-MB-435S melanoma cell line.
      Title: Talin2 and KANK2 functionally interact to regulate microtubule dynamics, paclitaxel sensitivity and cell migration in the MDA-MB-435S melanoma cell line.
    3. KANK2 protein is required for targeting microtubules to focal adhesions.
      Title: A mechano-signalling network linking microtubules, myosin IIA filaments and integrin-based adhesions.
    4. liprin beta-1 is associated with expression of kank 1 and 2 proteins in melanoma
      Title: Association of liprin β-1 with kank proteins in melanoma.
    5. identified recessive mutations in kidney ankyrin repeat-containing protein 1 (KANK1), KANK2, and KANK4 in individuals with nephrotic syndrome.
      Title: KANK deficiency leads to podocyte dysfunction and nephrotic syndrome.
    6. Using whole-exome sequencing, authors identified a homozygous missense c.2009C>T mutation in KANK2
      Title: Mutation in KANK2, encoding a sequestering protein for steroid receptor coactivators, causes keratoderma and woolly hair.
    7. SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm.
      Title: SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Nephrotic syndrome 16
    MedGen: C4540453 OMIM: 617783 GeneReviews: Not available
    		not available
    Wooly hair-palmoplantar keratoderma syndrome
    MedGen: C4015202 OMIM: 616099 GeneReviews: Not available
    		not available

    EBI GWAS Catalog

    Description
    Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20004, KIAA1518, MGC119707, DKFZp434N161

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in kidney epithelium development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of G1/S transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of intracellular estrogen receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of intracellular estrogen receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of programmed cell death IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of vitamin D receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of vitamin D receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in podocyte cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of Rho protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    KN motif and ankyrin repeat domain-containing protein 2
    Names
    SRC-interacting protein
    SRC1-interacting protein
    ankyrin repeat domain-containing protein 25
    kidney ankyrin repeat-containing protein 2
    matrix-remodeling-associated protein 3
    steroid receptor coactivator interacting protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051186.2 RefSeqGene

      Range
      5320..38595
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001136191.3 → NP_001129663.1  KN motif and ankyrin repeat domain-containing protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001129663.1

      Status: REVIEWED

      Source sequence(s)
      AC009000, AC011485
      Consensus CDS
      CCDS12255.1
      UniProtKB/Swiss-Prot
      B0I1P4, Q3KQZ3, Q63ZY3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210
      Related
      ENSP00000465650.1, ENST00000586659.6
      Conserved Domains (4) summary
      COG0666
      Location:651 → 806
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:739 → 769
      ANK; ANK repeat [structural motif]
      pfam12075
      Location:31 → 69
      KN_motif; KN motif
      pfam12796
      Location:743 → 828
      Ank_2; Ankyrin repeats (3 copies)

    2. NM_001329451.2 → NP_001316380.1  KN motif and ankyrin repeat domain-containing protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC009000, AC011485
      Consensus CDS
      CCDS12255.1
      UniProtKB/Swiss-Prot
      B0I1P4, Q3KQZ3, Q63ZY3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210
      Conserved Domains (4) summary
      COG0666
      Location:651 → 806
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:739 → 769
      ANK; ANK repeat [structural motif]
      pfam12075
      Location:31 → 69
      KN_motif; KN motif
      pfam12796
      Location:743 → 828
      Ank_2; Ankyrin repeats (3 copies)

    3. NM_001379548.1 → NP_001366477.1  KN motif and ankyrin repeat domain-containing protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC009000, AC011485
      Consensus CDS
      CCDS54219.1
      Conserved Domains (5) summary
      COG0666
      Location:659 → 814
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      PRK13108
      Location:450 → 593
      PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
      sd00045
      Location:747 → 777
      ANK; ANK repeat [structural motif]
      pfam12075
      Location:31 → 69
      KN_motif; KN motif
      pfam12796
      Location:751 → 836
      Ank_2; Ankyrin repeats (3 copies)

    4. NM_001379549.1 → NP_001366478.1  KN motif and ankyrin repeat domain-containing protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC009000, AC011485
      Consensus CDS
      CCDS54219.1
      Related
      ENSP00000468002.1, ENST00000589359.5
      Conserved Domains (5) summary
      COG0666
      Location:659 → 814
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      PRK13108
      Location:450 → 593
      PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
      sd00045
      Location:747 → 777
      ANK; ANK repeat [structural motif]
      pfam12075
      Location:31 → 69
      KN_motif; KN motif
      pfam12796
      Location:751 → 836
      Ank_2; Ankyrin repeats (3 copies)

    5. NM_001379550.1 → NP_001366479.1  KN motif and ankyrin repeat domain-containing protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC009000, AC011485
      Consensus CDS
      CCDS54219.1
      Conserved Domains (5) summary
      COG0666
      Location:659 → 814
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      PRK13108
      Location:450 → 593
      PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
      sd00045
      Location:747 → 777
      ANK; ANK repeat [structural motif]
      pfam12075
      Location:31 → 69
      KN_motif; KN motif
      pfam12796
      Location:751 → 836
      Ank_2; Ankyrin repeats (3 copies)

    6. NM_001379551.1 → NP_001366480.1  KN motif and ankyrin repeat domain-containing protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC009000, AC011485
      Consensus CDS
      CCDS54219.1
      Conserved Domains (5) summary
      COG0666
      Location:659 → 814
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      PRK13108
      Location:450 → 593
      PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
      sd00045
      Location:747 → 777
      ANK; ANK repeat [structural motif]
      pfam12075
      Location:31 → 69
      KN_motif; KN motif
      pfam12796
      Location:751 → 836
      Ank_2; Ankyrin repeats (3 copies)

    7. NM_001379552.1 → NP_001366481.1  KN motif and ankyrin repeat domain-containing protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC009000, AC011485
      Consensus CDS
      CCDS54219.1
      Conserved Domains (5) summary
      COG0666
      Location:659 → 814
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      PRK13108
      Location:450 → 593
      PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
      sd00045
      Location:747 → 777
      ANK; ANK repeat [structural motif]
      pfam12075
      Location:31 → 69
      KN_motif; KN motif
      pfam12796
      Location:751 → 836
      Ank_2; Ankyrin repeats (3 copies)

    8. NM_001379553.1 → NP_001366482.1  KN motif and ankyrin repeat domain-containing protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC009000, AC011485
      Consensus CDS
      CCDS54219.1
      Conserved Domains (5) summary
      COG0666
      Location:659 → 814
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      PRK13108
      Location:450 → 593
      PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
      sd00045
      Location:747 → 777
      ANK; ANK repeat [structural motif]
      pfam12075
      Location:31 → 69
      KN_motif; KN motif
      pfam12796
      Location:751 → 836
      Ank_2; Ankyrin repeats (3 copies)

    9. NM_001379554.1 → NP_001366483.1  KN motif and ankyrin repeat domain-containing protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC009000, AC011485
      Consensus CDS
      CCDS54219.1
      Conserved Domains (5) summary
      COG0666
      Location:659 → 814
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      PRK13108
      Location:450 → 593
      PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
      sd00045
      Location:747 → 777
      ANK; ANK repeat [structural motif]
      pfam12075
      Location:31 → 69
      KN_motif; KN motif
      pfam12796
      Location:751 → 836
      Ank_2; Ankyrin repeats (3 copies)

    10. NM_001379555.1 → NP_001366484.1  KN motif and ankyrin repeat domain-containing protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC009000, AC011485
      Consensus CDS
      CCDS12255.1
      UniProtKB/Swiss-Prot
      B0I1P4, Q3KQZ3, Q63ZY3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210
      Conserved Domains (4) summary
      COG0666
      Location:651 → 806
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:739 → 769
      ANK; ANK repeat [structural motif]
      pfam12075
      Location:31 → 69
      KN_motif; KN motif
      pfam12796
      Location:743 → 828
      Ank_2; Ankyrin repeats (3 copies)

    11. NM_001379556.1 → NP_001366485.1  KN motif and ankyrin repeat domain-containing protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC009000, AC011485
      Consensus CDS
      CCDS12255.1
      UniProtKB/Swiss-Prot
      B0I1P4, Q3KQZ3, Q63ZY3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210
      Conserved Domains (4) summary
      COG0666
      Location:651 → 806
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:739 → 769
      ANK; ANK repeat [structural motif]
      pfam12075
      Location:31 → 69
      KN_motif; KN motif
      pfam12796
      Location:743 → 828
      Ank_2; Ankyrin repeats (3 copies)

    12. NM_001379557.1 → NP_001366486.1  KN motif and ankyrin repeat domain-containing protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC009000, AC011485
      Consensus CDS
      CCDS12255.1
      UniProtKB/Swiss-Prot
      B0I1P4, Q3KQZ3, Q63ZY3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210
      Conserved Domains (4) summary
      COG0666
      Location:651 → 806
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:739 → 769
      ANK; ANK repeat [structural motif]
      pfam12075
      Location:31 → 69
      KN_motif; KN motif
      pfam12796
      Location:743 → 828
      Ank_2; Ankyrin repeats (3 copies)

    13. NM_001379558.1 → NP_001366487.1  KN motif and ankyrin repeat domain-containing protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC009000, AC011485
      Consensus CDS
      CCDS12255.1
      UniProtKB/Swiss-Prot
      B0I1P4, Q3KQZ3, Q63ZY3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210
      Conserved Domains (4) summary
      COG0666
      Location:651 → 806
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:739 → 769
      ANK; ANK repeat [structural motif]
      pfam12075
      Location:31 → 69
      KN_motif; KN motif
      pfam12796
      Location:743 → 828
      Ank_2; Ankyrin repeats (3 copies)

    14. NM_001379559.1 → NP_001366488.1  KN motif and ankyrin repeat domain-containing protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC009000, AC011485
      Consensus CDS
      CCDS12255.1
      UniProtKB/Swiss-Prot
      B0I1P4, Q3KQZ3, Q63ZY3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210
      Conserved Domains (4) summary
      COG0666
      Location:651 → 806
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:739 → 769
      ANK; ANK repeat [structural motif]
      pfam12075
      Location:31 → 69
      KN_motif; KN motif
      pfam12796
      Location:743 → 828
      Ank_2; Ankyrin repeats (3 copies)

    15. NM_001379560.1 → NP_001366489.1  KN motif and ankyrin repeat domain-containing protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC009000, AC011485
      Consensus CDS
      CCDS12255.1
      UniProtKB/Swiss-Prot
      B0I1P4, Q3KQZ3, Q63ZY3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210
      Conserved Domains (4) summary
      COG0666
      Location:651 → 806
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:739 → 769
      ANK; ANK repeat [structural motif]
      pfam12075
      Location:31 → 69
      KN_motif; KN motif
      pfam12796
      Location:743 → 828
      Ank_2; Ankyrin repeats (3 copies)

    16. NM_001379561.1 → NP_001366490.1  KN motif and ankyrin repeat domain-containing protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC009000, AC011485
      Consensus CDS
      CCDS12255.1
      UniProtKB/Swiss-Prot
      B0I1P4, Q3KQZ3, Q63ZY3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210
      Conserved Domains (4) summary
      COG0666
      Location:651 → 806
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:739 → 769
      ANK; ANK repeat [structural motif]
      pfam12075
      Location:31 → 69
      KN_motif; KN motif
      pfam12796
      Location:743 → 828
      Ank_2; Ankyrin repeats (3 copies)

    17. NM_001379562.1 → NP_001366491.1  KN motif and ankyrin repeat domain-containing protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC009000, AC011485
      Consensus CDS
      CCDS12255.1
      UniProtKB/Swiss-Prot
      B0I1P4, Q3KQZ3, Q63ZY3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210
      Conserved Domains (4) summary
      COG0666
      Location:651 → 806
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:739 → 769
      ANK; ANK repeat [structural motif]
      pfam12075
      Location:31 → 69
      KN_motif; KN motif
      pfam12796
      Location:743 → 828
      Ank_2; Ankyrin repeats (3 copies)

    18. NM_001379563.1 → NP_001366492.1  KN motif and ankyrin repeat domain-containing protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC009000, AC011485
      Consensus CDS
      CCDS12255.1
      UniProtKB/Swiss-Prot
      B0I1P4, Q3KQZ3, Q63ZY3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210
      Conserved Domains (4) summary
      COG0666
      Location:651 → 806
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:739 → 769
      ANK; ANK repeat [structural motif]
      pfam12075
      Location:31 → 69
      KN_motif; KN motif
      pfam12796
      Location:743 → 828
      Ank_2; Ankyrin repeats (3 copies)

    19. NM_015493.7 → NP_056308.3  KN motif and ankyrin repeat domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_056308.3

      Status: REVIEWED

      Source sequence(s)
      AC009000, AC011485
      Consensus CDS
      CCDS54219.1
      UniProtKB/Swiss-Prot
      Q63ZY3
      Conserved Domains (5) summary
      COG0666
      Location:659 → 814
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      PRK13108
      Location:450 → 593
      PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
      sd00045
      Location:747 → 777
      ANK; ANK repeat [structural motif]
      pfam12075
      Location:31 → 69
      KN_motif; KN motif
      pfam12796
      Location:751 → 836
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      11164270..11197865 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438576.1 → XP_047294532.1  KN motif and ankyrin repeat domain-containing protein 2 isoform X2

      UniProtKB/Swiss-Prot
      B0I1P4, Q3KQZ3, Q63ZY3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210

    2. XM_047438575.1 → XP_047294531.1  KN motif and ankyrin repeat domain-containing protein 2 isoform X2

      UniProtKB/Swiss-Prot
      B0I1P4, Q3KQZ3, Q63ZY3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210

    3. XM_047438572.1 → XP_047294528.1  KN motif and ankyrin repeat domain-containing protein 2 isoform X2

      UniProtKB/Swiss-Prot
      B0I1P4, Q3KQZ3, Q63ZY3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210

    4. XM_047438569.1 → XP_047294525.1  KN motif and ankyrin repeat domain-containing protein 2 isoform X1

    5. XM_047438573.1 → XP_047294529.1  KN motif and ankyrin repeat domain-containing protein 2 isoform X2

      UniProtKB/Swiss-Prot
      B0I1P4, Q3KQZ3, Q63ZY3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210
      Related
      ENSP00000467029.1, ENST00000589894.1

    6. XM_047438574.1 → XP_047294530.1  KN motif and ankyrin repeat domain-containing protein 2 isoform X2

      UniProtKB/Swiss-Prot
      B0I1P4, Q3KQZ3, Q63ZY3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210

    7. XM_047438571.1 → XP_047294527.1  KN motif and ankyrin repeat domain-containing protein 2 isoform X1

    8. XM_047438577.1 → XP_047294533.1  KN motif and ankyrin repeat domain-containing protein 2 isoform X2

      UniProtKB/Swiss-Prot
      B0I1P4, Q3KQZ3, Q63ZY3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210

    9. XM_047438570.1 → XP_047294526.1  KN motif and ankyrin repeat domain-containing protein 2 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      11291296..11324866 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63ZY3.1 GenPept UniProtKB/Swiss-Prot:Q63ZY3

    Gene LinkOut

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