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    FAM174A family with sequence similarity 174 member A [ Homo sapiens (human) ]

    Gene ID: 345757, updated on 3-Nov-2024

    Summary

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    Official Symbol
    FAM174Aprovided by HGNC
    Official Full Name
    family with sequence similarity 174 member Aprovided by HGNC
    Primary source
    HGNC:HGNC:24943
    See related
    Ensembl:ENSG00000174132 AllianceGenome:HGNC:24943
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NS5ATP6; TMEM157; UNQ1912; HGS_RE408
    Summary
    Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 14.8), adrenal (RPKM 11.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FAM174A in Genome Data Viewer
    Location:
    5q21.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (100535374..100586741)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (101043697..101095060)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (99871078..99922445)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379100 Neighboring gene FAM174A divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22841 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22842 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22843 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16206 Neighboring gene MPRA-validated peak5372 silencer Neighboring gene MPRA-validated peak5373 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:100058179-100058822 Neighboring gene RN7SK pseudogene 62 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:100112471-100113670 Neighboring gene NANOG hESC enhancer GRCh37_chr5:100121674-100122204 Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 Neighboring gene microRNA 548p

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. USP9X deubiquitinates and stabilizes CDC123 to promote breast carcinogenesis through regulating cell cycle. Song N, et al. Mol Carcinog, 2023 Oct. PMID 37314216
    2. NS5ATP6 modulates intracellular triglyceride content through FGF21 and independently of SIRT1 and SREBP1. Li Z, et al. Biochem Biophys Res Commun, 2016 Jun 17. PMID 27179781
    3. Insights into human Lck SH3 domain binding specificity: different binding modes of artificial and native ligands. Tran T, et al. Biochemistry, 2005 Nov 15. PMID 16274251
    4. Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy. Liu C, et al. Cancer Res, 2019 May 1. PMID 30862715, Free PMC Article
    5. A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition. Benslimane Y, et al. Aging Cell, 2021 Apr. PMID 33660365, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NS5ATP6 regulates the intracellular triglyceride level via FGF21, and independently of SIRT1 and SREBP1.
      Title: NS5ATP6 modulates intracellular triglyceride content through FGF21 and independently of SIRT1 and SREBP1.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC17345

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    membrane protein FAM174A
    Names
    HCV NS5A-transactivated protein 6
    hepatitis C virus NS5A-transactivated protein 6
    hepatitis C virus nonstructural protein 5A trans-activated protein 6
    transmembrane protein 157

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198507.3 → NP_940909.1  membrane protein FAM174A precursor

      See identical proteins and their annotated locations for NP_940909.1

      Status: VALIDATED

      Source sequence(s)
      AY359108, BC027332, BI462478
      Consensus CDS
      CCDS4090.1
      UniProtKB/Swiss-Prot
      A8K0H4, Q8TBP5
      Related
      ENSP00000307954.2, ENST00000312637.5
      Conserved Domains (1) summary
      pfam06679
      Location:35 → 190
      DUF1180; Protein of unknown function (DUF1180)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      100535374..100586741
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006714600.2 → XP_006714663.1  membrane protein FAM174A isoform X1

      Conserved Domains (1) summary
      pfam06679
      Location:35 → 190
      DUF1180; Protein of unknown function (DUF1180)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      101043697..101095060
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352511.1 → XP_054208486.1  membrane protein FAM174A isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TBP5.1 GenPept UniProtKB/Swiss-Prot:Q8TBP5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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