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    Cnot7 CCR4-NOT transcription complex, subunit 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306492, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cnot7provided by RGD
    Official Full Name
    CCR4-NOT transcription complex, subunit 7provided by RGD
    Primary source
    RGD:1305313
    See related
    EnsemblRapid:ENSRNOG00000012263 AllianceGenome:RGD:1305313
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription factor binding activity; poly(A)-specific ribonuclease activity; and transcription corepressor activity. Predicted to be involved in several processes, including negative regulation of type I interferon-mediated signaling pathway; positive regulation of mRNA catabolic process; and positive regulation of viral genome replication. Predicted to act upstream of or within P-body assembly and positive regulation of RNA metabolic process. Predicted to be located in cytoplasm and nuclear speck. Predicted to be part of CCR4-NOT core complex. Predicted to be active in P-body. Biomarker of male infertility. Orthologous to human CNOT7 (CCR4-NOT transcription complex subunit 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 153.6), Thymus (RPKM 149.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cnot7 in Genome Data Viewer
    Location:
    16q12.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (58478882..58498046)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (51775416..51794581)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (54899452..54918616)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase domain 24 Neighboring gene myotubularin related protein 7 Neighboring gene VPS37A subunit of ESCRT-I Neighboring gene zinc finger DHHC-type palmitoyltransferase 2 Neighboring gene mitochondrial calcium uptake family, member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Accumulated HSV1-TK proteins interfere with spermatogenesis through a disruption of the integrity of Sertoli-germ cell junctions. Cai LY, et al. J Reprod Dev, 2012. PMID 22785219
    2. hCAF1/CNOT7 regulates interferon signalling by targeting STAT1. Chapat C, et al. EMBO J, 2013 Mar 6. PMID 23386060, Free PMC Article
    3. Structural basis for the antiproliferative activity of the Tob-hCaf1 complex. Horiuchi M, et al. J Biol Chem, 2009 May 8. PMID 19276069, Free PMC Article
    4. The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation. Aslam A, et al. Mol Biol Cell, 2009 Sep. PMID 19605561, Free PMC Article
    5. Conservation of the deadenylase activity of proteins of the Caf1 family in human. Bianchin C, et al. RNA, 2005 Apr. PMID 15769875, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A)-specific ribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A)-specific ribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within P-body assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within deadenylation-dependent decapping of nuclear-transcribed mRNA ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in miRNA-mediated gene silencing by mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within nuclear-transcribed mRNA poly(A) tail shortening ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear-transcribed mRNA poly(A) tail shortening ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulatory ncRNA-mediated gene silencing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of CCR4-NOT complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of CCR4-NOT core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in intracellular non-membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    CCR4-NOT transcription complex subunit 7
    NP_001100783.1
    XP_017455614.1
    XP_017455615.1
    XP_017455616.1
    XP_017455617.1
    XP_038950462.1
    XP_038950465.1
    XP_063131501.1
    XP_063131502.1
    XP_063131503.1
    XP_063131504.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107313.1 → NP_001100783.1  CCR4-NOT transcription complex subunit 7

      See identical proteins and their annotated locations for NP_001100783.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473995
      UniProtKB/TrEMBL
      A6JPV7, B3DMA5, F7F9V0
      Conserved Domains (1) summary
      cl23804
      Location:1 → 279
      CAF1; CAF1 family ribonuclease

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      58478882..58498046
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017600125.3 → XP_017455614.1  CCR4-NOT transcription complex subunit 7 isoform X1

      Related
      ENSRNOP00000016882.5, ENSRNOT00000016882.7
      Conserved Domains (1) summary
      cl23804
      Location:1 → 292
      CAF1; CAF1 family ribonuclease

    2. XM_039094534.2 → XP_038950462.1  CCR4-NOT transcription complex subunit 7 isoform X3

      Conserved Domains (1) summary
      cl23804
      Location:1 → 228
      CAF1; CAF1 family ribonuclease

    3. XM_039094537.2 → XP_038950465.1  CCR4-NOT transcription complex subunit 7 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AEC4
      Related
      ENSRNOP00000092791.1, ENSRNOT00000099744.2
      Conserved Domains (1) summary
      cl23804
      Location:1 → 215
      CAF1; CAF1 family ribonuclease

    4. XM_063275432.1 → XP_063131502.1  CCR4-NOT transcription complex subunit 7 isoform X2

      UniProtKB/TrEMBL
      A6JPV7, B3DMA5, F7F9V0
      Related
      ENSRNOP00000106115.1, ENSRNOT00000166465.1

    5. XM_063275431.1 → XP_063131501.1  CCR4-NOT transcription complex subunit 7 isoform X2

      UniProtKB/TrEMBL
      A6JPV7, B3DMA5, F7F9V0

    6. XM_017600128.3 → XP_017455617.1  CCR4-NOT transcription complex subunit 7 isoform X1

      Conserved Domains (1) summary
      cl23804
      Location:1 → 292
      CAF1; CAF1 family ribonuclease

    7. XM_063275434.1 → XP_063131504.1  CCR4-NOT transcription complex subunit 7 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AEC4

    8. XM_063275433.1 → XP_063131503.1  CCR4-NOT transcription complex subunit 7 isoform X2

      UniProtKB/TrEMBL
      A6JPV7, B3DMA5, F7F9V0

    9. XM_017600127.3 → XP_017455616.1  CCR4-NOT transcription complex subunit 7 isoform X1

      Conserved Domains (1) summary
      cl23804
      Location:1 → 292
      CAF1; CAF1 family ribonuclease

    10. XM_017600126.3 → XP_017455615.1  CCR4-NOT transcription complex subunit 7 isoform X1

      Conserved Domains (1) summary
      cl23804
      Location:1 → 292
      CAF1; CAF1 family ribonuclease
    Nucleotide Protein Strain
    Heading Accession and Version

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