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    Chst3 carbohydrate sulfotransferase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84468, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Chst3provided by RGD
    Official Full Name
    carbohydrate sulfotransferase 3provided by RGD
    Primary source
    RGD:620355
    See related
    EnsemblRapid:ENSRNOG00000000572 AllianceGenome:RGD:620355
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables proteoglycan sulfotransferase activity. Involved in chondroitin sulfate biosynthetic process and peripheral nervous system axon regeneration. Predicted to be located in Golgi membrane. Predicted to be active in trans-Golgi network. Human ortholog(s) of this gene implicated in osteochondrodysplasia and spondyloepiphyseal dysplasia with congenital joint dislocations. Orthologous to human CHST3 (carbohydrate sulfotransferase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 106.6), Spleen (RPKM 46.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Chst3 in Genome Data Viewer
    Location:
    20q11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (28657308..28694976, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (28114386..28152046, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (29731828..29768656, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483914 Neighboring gene SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2 Neighboring gene ribosomal protein S29, pseudogene 7 Neighboring gene ribosomal protein L37A, pseudogene 15 Neighboring gene prosaposin Neighboring gene cadherin-related 23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Upregulation of chondroitin 6-sulphotransferase-1 facilitates Schwann cell migration during axonal growth. Liu J, et al. J Cell Sci, 2006 Mar 1. PMID 16495484
    2. Loss of chondroitin 6-O-sulfotransferase-1 function results in severe human chondrodysplasia with progressive spinal involvement. Thiele H, et al. Proc Natl Acad Sci U S A, 2004 Jul 6. PMID 15215498, Free PMC Article
    3. Functional expression and genomic structure of human chondroitin 6-sulfotransferase. Tsutsumi K, et al. FEBS Lett, 1998 Dec 18. PMID 9883891
    4. Chondroitin 4-sulphotransferase-1 and chondroitin 6-sulphotransferase-1 are affected differently by uronic acid residues neighbouring the acceptor GalNAc residues. Yamada T, et al. Biochem J, 2004 Dec 15. PMID 15324304, Free PMC Article
    5. Functional analysis of the chondroitin 6-sulfotransferase gene in relation to lymphocyte subpopulations, brain development, and oversulfated chondroitin sulfates. Uchimura K, et al. J Biol Chem, 2002 Jan 11. PMID 11696535

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-acetylglucosamine 6-O-sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chondroitin 6-sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chondroitin 6-sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chondroitin 6-sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chondroitin 6-sulfotransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables proteoglycan sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables proteoglycan sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proteoglycan sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-acetylglucosamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in T cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within T cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chondroitin sulfate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chondroitin sulfate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chondroitin sulfate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chondroitin sulfate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chondroitin sulfate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chondroitin sulfate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in peripheral nervous system axon regeneration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to axon injury IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in sulfur compound metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sulfur compound metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    carbohydrate sulfotransferase 3
    Names
    C6ST-1
    GST-0
    carbohydrate (chondroitin 6) sulfotransferase 3
    carbohydrate (chondroitin 6/keratan) sulfotransferase 3
    chondroitin 6-O-sulfotransferase 1
    chondroitin 6-sulfotransferase 3
    galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0
    NP_445860.3
    XP_038955055.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053408.3 → NP_445860.3  carbohydrate sulfotransferase 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      Related
      ENSRNOP00000000697.2, ENSRNOT00000000697.5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      28657308..28694976 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099127.2 → XP_038955055.1  carbohydrate sulfotransferase 3 isoform X1

      UniProtKB/Swiss-Prot
      Q9QZL2
      UniProtKB/TrEMBL
      A6K3W8, F1LN90
      Conserved Domains (1) summary
      pfam00685
      Location:269 → 453
      Sulfotransfer_1; Sulfotransferase domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZL2.2 GenPept UniProtKB/Swiss-Prot:Q9QZL2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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