U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Lbr lamin B receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 89789, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Lbrprovided by RGD
    Official Full Name
    lamin B receptorprovided by RGD
    Primary source
    RGD:620813
    See related
    EnsemblRapid:ENSRNOG00000052574 AllianceGenome:RGD:620813
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    C14SR; Nbp60
    Summary
    Enables nuclear localization sequence binding activity and protein-folding chaperone binding activity. Predicted to be involved in cholesterol biosynthetic process and neutrophil differentiation. Located in nuclear envelope. Part of nuclear pore. Human ortholog(s) of this gene implicated in Greenberg dysplasia; Pelger-Huet anomaly; and primary biliary cholangitis. Orthologous to human LBR (lamin B receptor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 904.1), Spleen (RPKM 620.0) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Lbr in Genome Data Viewer
    Location:
    13q26
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (96071058..96095709, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (93539386..93564026, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (100431390..100450209, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 121, retrogene 1 Neighboring gene dynein axonemal heavy chain 14 Neighboring gene mitochondrial ribosomal protein S11, pseudogene 1 Neighboring gene 60S ribosomal protein L36a-like Neighboring gene ENAH, actin regulator

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Purification of a 60 kDa nuclear localization signal binding protein in rat liver nuclear envelopes and characterization of its properties. Haino M, et al. J Biochem, 1993 Mar. PMID 8486604
    2. Autoantibodies from patients with primary biliary cirrhosis recognize a region within the nucleoplasmic domain of inner nuclear membrane protein LBR. Lin F, et al. Hepatology, 1996 Jan. PMID 8550049
    3. The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations. Tsai PL, et al. Elife, 2016 Jun 23. PMID 27336722, Free PMC Article
    4. Reduced lymphocyte longevity and homeostatic proliferation in lamin B receptor-deficient mice results in profound and progressive lymphopenia. Verhagen AM, et al. J Immunol, 2012 Jan 1. PMID 22105998
    5. Mutations causing Greenberg dysplasia but not Pelger anomaly uncouple enzymatic from structural functions of a nuclear membrane protein. Clayton P, et al. Nucleus, 2010 Jul-Aug. PMID 21327084, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BEMAD was used on a purified nuclear pore complex preparation to map novel sites of O-GlcNAc modification on Lbr.
      Title: Mapping sites of O-GlcNAc modification using affinity tags for serine and threonine post-translational modifications.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADPH binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADPH binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADPH binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables chromatin-protein adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromo shadow domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromo shadow domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables delta14-sterol reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables delta14-sterol reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables delta14-sterol reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables delta14-sterol reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nuclear localization sequence binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-folding chaperone binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cholesterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cholesterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cholesterol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cholesterol biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neutrophil differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neutrophil differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neutrophil differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in random inactivation of X chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear lamina IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    delta(14)-sterol reductase LBR
    Names
    3-beta-hydroxysterol Delta (14)-reductase
    C-14 sterol reductase
    delta-14-SR
    integral nuclear envelope inner membrane protein
    sterol C14-reductase
    NP_001380594.1
    XP_038947059.1
    XP_038947060.1
    XP_038947061.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393665.1 → NP_001380594.1  delta(14)-sterol reductase LBR

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A8I6AEP6, A6JGK3
      Related
      ENSRNOP00000090637.2, ENSRNOT00000095219.2
      Conserved Domains (2) summary
      pfam09465
      Location:1 → 55
      LBR_tudor; Lamin-B receptor of TUDOR domain
      cl21511
      Location:213 → 621
      PEMT; Phospholipid methyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      96071058..96095709 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091132.2 → XP_038947060.1  delta(14)-sterol reductase LBR isoform X1

      UniProtKB/TrEMBL
      A0A8I6AEP6, A6JGK3
      Conserved Domains (2) summary
      pfam09465
      Location:1 → 55
      LBR_tudor; Lamin-B receptor of TUDOR domain
      cl21511
      Location:213 → 621
      PEMT; Phospholipid methyltransferase

    2. XM_039091131.2 → XP_038947059.1  delta(14)-sterol reductase LBR isoform X1

      UniProtKB/TrEMBL
      A0A8I6AEP6, A6JGK3
      Conserved Domains (2) summary
      pfam09465
      Location:1 → 55
      LBR_tudor; Lamin-B receptor of TUDOR domain
      cl21511
      Location:213 → 621
      PEMT; Phospholipid methyltransferase

    3. XM_039091133.2 → XP_038947061.1  delta(14)-sterol reductase LBR isoform X1

      UniProtKB/TrEMBL
      A0A8I6AEP6, A6JGK3
      Conserved Domains (2) summary
      pfam09465
      Location:1 → 55
      LBR_tudor; Lamin-B receptor of TUDOR domain
      cl21511
      Location:213 → 621
      PEMT; Phospholipid methyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08984.1 GenPept UniProtKB/Swiss-Prot:O08984

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials