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    G3bp2 G3BP stress granule assembly factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305240, updated on 2-Nov-2024

    Summary

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    Official Symbol
    G3bp2provided by RGD
    Official Full Name
    G3BP stress granule assembly factor 2provided by RGD
    Primary source
    RGD:1309571
    See related
    EnsemblRapid:ENSRNOG00000002433 AllianceGenome:RGD:1309571
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309571
    Summary
    Predicted to enable mRNA binding activity and molecular condensate scaffold activity. Predicted to be involved in positive regulation of stress granule assembly; protein homooligomerization; and stress granule assembly. Predicted to be active in cytoplasmic stress granule and cytosol. Orthologous to human G3BP2 (G3BP stress granule assembly factor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 367.9), Muscle (RPKM 299.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See G3bp2 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (16216684..16304828)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (15932403..16020555)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (17437145..17523254)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene endotoxic shock protective protein U9-ORF-like Neighboring gene small nucleolar RNA, H/ACA box 57 Neighboring gene USO1 vesicle transport factor Neighboring gene small nucleolar RNA U13 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 2, pseudogene 1 Neighboring gene uncharacterized LOC120096578 Neighboring gene small Cajal body-specific RNA 23 like 2 Neighboring gene Sec61 translocon subunit gamma, pseudogene 2 Neighboring gene cyclin dependent kinase like 2 Neighboring gene odontogenesis associated phosphoprotein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. G3BP2 is involved in isoproterenol-induced cardiac hypertrophy through activating the NF-κB signaling pathway. Hong HQ, et al. Acta Pharmacol Sin, 2018 Feb. PMID 28816235, Free PMC Article
    2. lncRNA XIST knockdown suppresses hypoxia/reoxygenation (H/R)-induced apoptosis of H9C2 cells by regulating miR-545-3p/G3BP2. Xiao X, et al. IUBMB Life, 2021 Sep. PMID 34060227
    3. Host factors associated with the Sindbis virus RNA-dependent RNA polymerase: role for G3BP1 and G3BP2 in virus replication. Cristea IM, et al. J Virol, 2010 Jul. PMID 20392851, Free PMC Article
    4. Both G3BP1 and G3BP2 contribute to stress granule formation. Matsuki H, et al. Genes Cells, 2013 Feb. PMID 23279204
    5. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. lncRNA XIST knockdown suppresses hypoxia/reoxygenation (H/R)-induced apoptosis of H9C2 cells by regulating miR-545-3p/G3BP2.
      Title: lncRNA XIST knockdown suppresses hypoxia/reoxygenation (H/R)-induced apoptosis of H9C2 cells by regulating miR-545-3p/G3BP2.
    2. new insight into the functions of G3BP2
      Title: G3BP2 is involved in isoproterenol-induced cardiac hypertrophy through activating the NF-κB signaling pathway.
    3. Two related proteins found in association with nsP4 at both times of infection, GTPase-activating protein (SH3 domain) binding protein 1 (G3BP1) and G3BP2 were also previously identified as associated with sindbis virus nsP2 and nsP3.
      Title: Host factors associated with the Sindbis virus RNA-dependent RNA polymerase: role for G3BP1 and G3BP2 in virus replication.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular condensate scaffold activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular condensate scaffold activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of stress granule assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stress granule assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in stress granule assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ras GTPase-activating protein-binding protein 2
    Names
    GTPase activating protein (SH3 domain) binding protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013989.2 → NP_001014011.1  ras GTPase-activating protein-binding protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001014011.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I5ZNB2, A0A8I6ABI3, Q6AY21
      Related
      ENSRNOP00000091154.1, ENSRNOT00000094514.3
      Conserved Domains (2) summary
      cd00780
      Location:7 → 135
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cd12464
      Location:293 → 375
      RRM_G3BP2; RNA recognition motif (RRM) found in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins

    2. NM_001401436.1 → NP_001388365.1  ras GTPase-activating protein-binding protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A6KKA6, F7F5P9

    3. NM_001401437.1 → NP_001388366.1  ras GTPase-activating protein-binding protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A6KKA6, F7F5P9

    4. NM_001401438.1 → NP_001388367.1  ras GTPase-activating protein-binding protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I6ABI3, Q6AY21

    5. NM_001401439.1 → NP_001388368.1  ras GTPase-activating protein-binding protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I6ABI3, Q6AY21

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      16216684..16304828
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250734.5 → XP_006250796.1  ras GTPase-activating protein-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006250796.1

      UniProtKB/TrEMBL
      A0A8I5ZNB2, A6KKA6, F7F5P9
      Related
      ENSRNOP00000098567.2, ENSRNOT00000121014.2
      Conserved Domains (3) summary
      COG0724
      Location:319 → 414
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd00780
      Location:7 → 135
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cd12464
      Location:326 → 408
      RRM_G3BP2; RNA recognition motif in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins

    2. XM_006250736.5 → XP_006250798.1  ras GTPase-activating protein-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006250798.1

      UniProtKB/TrEMBL
      A0A8I5ZNB2, A6KKA6, F7F5P9
      Conserved Domains (3) summary
      COG0724
      Location:319 → 414
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd00780
      Location:7 → 135
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cd12464
      Location:326 → 408
      RRM_G3BP2; RNA recognition motif in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins

    3. XM_063273059.1 → XP_063129129.1  ras GTPase-activating protein-binding protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ABI3, Q6AY21
    Nucleotide Protein Strain
    Heading Accession and Version

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