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    Sec61a2 SEC61 translocon subunit alpha 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361273, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Sec61a2provided by RGD
    Official Full Name
    SEC61 translocon subunit alpha 2provided by RGD
    Primary source
    RGD:1305948
    See related
    EnsemblRapid:ENSRNOG00000023278 AllianceGenome:RGD:1305948
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein transmembrane transporter activity; ribosome binding activity; and signal sequence binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, translocation and posttranslational protein targeting to membrane, translocation. Predicted to be integral component of membrane. Predicted to be part of Sec61 translocon complex. Orthologous to human SEC61A2 (SEC61 translocon subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 164.0), Heart (RPKM 135.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    17q12.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (77316901..77354978)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (72407574..72445630)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (76358947..76385860)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene dehydrogenase E1 and transketolase domain containing 1 Neighboring gene cytochrome c oxidase subunit VIb polypeptide 1-like Neighboring gene large ribosomal subunit protein eL37-like Neighboring gene nudix hydrolase 5 Neighboring gene cell division cycle 123 Neighboring gene uncharacterized LOC102551026

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Deletion of SERP1/RAMP4, a component of the endoplasmic reticulum (ER) translocation sites, leads to ER stress. Hori O, et al. Mol Cell Biol, 2006 Jun. PMID 16705175, Free PMC Article
    2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signal sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in post-translational protein targeting to membrane, translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Sec61 translocon complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein transport protein Sec61 subunit alpha
    Names
    Sec61 alpha 2 subunit
    Sec61 translocon alpha 2 subunit
    Sec61, alpha subunit 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170343.1 → NP_001163814.1  protein transport protein Sec61 subunit alpha

      See identical proteins and their annotated locations for NP_001163814.1

      Status: VALIDATED

      Source sequence(s)
      BG381529, CB327956, CD373126, CK470805, CO567453
      UniProtKB/TrEMBL
      A0A8I6AA70, A0A8I6GFI1
      Related
      ENSRNOP00000097707.2, ENSRNOT00000119882.2
      Conserved Domains (1) summary
      PTZ00219
      Location:1 → 469
      PTZ00219; Sec61 alpha subunit; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      77316901..77354978
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095932.2 → XP_038951860.1  protein transport protein Sec61 subunit alpha isoform X1

      UniProtKB/TrEMBL
      D3ZEH3
      Related
      ENSRNOP00000082887.2, ENSRNOT00000100731.2
      Conserved Domains (1) summary
      PTZ00219
      Location:1 → 417
      PTZ00219; Sec61 alpha subunit; Provisional

    2. XM_006254257.5 → XP_006254319.1  protein transport protein Sec61 subunit alpha isoform X3

      UniProtKB/TrEMBL
      A0A8I6GFI1
      Conserved Domains (1) summary
      PTZ00219
      Location:1 → 381
      PTZ00219; Sec61 alpha subunit; Provisional

    3. XM_063276637.1 → XP_063132707.1  protein transport protein Sec61 subunit alpha isoform X4

      UniProtKB/TrEMBL
      A0A0U1RRQ7, A0A8I5ZUP9
      Related
      ENSRNOP00000081267.1, ENSRNOT00000092448.3

    4. XM_039095933.2 → XP_038951861.1  protein transport protein Sec61 subunit alpha isoform X2

      UniProtKB/TrEMBL
      A0A8L2Q9G3
      Conserved Domains (1) summary
      PTZ00219
      Location:4 → 399
      PTZ00219; Sec61 alpha subunit; Provisional

    RNA

    1. XR_005495306.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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