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    Hilpda hypoxia inducible lipid droplet-associated [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100361568, updated on 13-Apr-2024

    Summary

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    Symbol
    Hilpdaprovided by RGD
    Full Name
    hypoxia inducible lipid droplet-associatedprovided by RGD
    Primary source
    RGD:2319900
    See related
    Ensembl:ENSRNOG00000070930 AllianceGenome:RGD:2319900
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable signaling receptor binding activity. Predicted to be involved in several processes, including autocrine signaling; cellular response to hypoxia; and positive regulation of lipid storage. Predicted to be located in several cellular components, including cell surface; lipid droplet; and secretory granule. Orthologous to human HILPDA (hypoxia inducible lipid droplet associated). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 186.8), Uterus (RPKM 106.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hilpda in Genome Data Viewer
    Location:
    4q22
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (58836463..58839423)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (57871088..57874048)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (56547600..56550584)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene inosine monophosphate dehydrogenase 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134486744 Neighboring gene uncharacterized LOC103692085 Neighboring gene golgi associated RAB2 interactor 1A Neighboring gene golgi associated RAB2 interactor 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Hypoxia-inducible gene 2 promotes the immune escape of hepatocellular carcinoma from nature killer cells through the interleukin-10-STAT3 signaling pathway. Cui C, et al. J Exp Clin Cancer Res, 2019 May 29. PMID 31142329, Free PMC Article
    2. HIG2 promotes colorectal cancer progression via hypoxia-dependent and independent pathways. Kim SH, et al. Cancer Lett, 2013 Dec 1. PMID 23916472, Free PMC Article
    3. Hypoxia-inducible protein 2 (HIG2), a novel diagnostic marker for renal cell carcinoma and potential target for molecular therapy. Togashi A, et al. Cancer Res, 2005 Jun 1. PMID 15930302
    4. Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment. Denko N, et al. Clin Cancer Res, 2000 Feb. PMID 10690527
    5. Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1. Gimm T, et al. FASEB J, 2010 Nov. PMID 20624928

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. data uncover HILPDA as a novel PPAR target that raises hepatic triglyceride storage via regulation of triglyceride secretion.
      Title: Hypoxia-inducible lipid droplet-associated (HILPDA) is a novel peroxisome proliferator-activated receptor (PPAR) target involved in hepatic triglyceride secretion.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in autocrine signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of lipid storage ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    hypoxia-inducible lipid droplet-associated protein
    Names
    hypoxia-inducible protein 2-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399165.1 → NP_001386094.1  hypoxia-inducible lipid droplet-associated protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      Related
      ENSRNOT00000094767.1
      Conserved Domains (1) summary
      pfam15220
      Location:1 → 63
      HILPDA; Hypoxia-inducible lipid droplet-associated

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      58836463..58839423
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials