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    C2cd2l C2CD2-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300666, updated on 10-Oct-2024

    Summary

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    Official Symbol
    C2cd2lprovided by RGD
    Official Full Name
    C2CD2-likeprovided by RGD
    Primary source
    RGD:1310281
    See related
    EnsemblRapid:ENSRNOG00000009719 AllianceGenome:RGD:1310281
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tmem24
    Summary
    Predicted to enable insulin binding activity; phosphatidylinositol binding activity; and phosphatidylinositol transfer activity. Predicted to be involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in cortical endoplasmic reticulum and endoplasmic reticulum-plasma membrane contact site. Predicted to be integral component of membrane. Predicted to colocalize with cytoplasmic side of apical plasma membrane. Orthologous to human C2CD2L (C2CD2 like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 140.4), Kidney (RPKM 105.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See C2cd2l in Genome Data Viewer
    Location:
    8q22
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (53544887..53557127, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (44648074..44658856, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (48641792..48652119, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily G member 4 Neighboring gene histone H4 transcription factor Neighboring gene dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 Neighboring gene H2A.X variant histone

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Lipid transport by TMEM24 at ER-plasma membrane contacts regulates pulsatile insulin secretion. Lees JA, et al. Science, 2017 Feb 17. PMID 28209843, Free PMC Article
    2. Insulin biosynthetic interaction network component, TMEM24, facilitates insulin reserve pool release. Pottekat A, et al. Cell Rep, 2013 Sep 12. PMID 24012759, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables insulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol transfer activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in intermembrane lipid transfer IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cortical endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with cytoplasmic side of apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic side of apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum-plasma membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phospholipid transfer protein C2CD2L
    Names
    C2 calcium-dependent domain containing 2-like
    C2 domain-containing protein 2-like
    transmembrane protein 24

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011996.2 → NP_001011996.1  phospholipid transfer protein C2CD2L isoform 3

      See identical proteins and their annotated locations for NP_001011996.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      Q5U2P5
      Conserved Domains (1) summary
      cl14603
      Location:288 → 412
      C2; C2 domain

    2. NM_001433224.1 → NP_001420153.1  phospholipid transfer protein C2CD2L isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      F7EUW3

    3. NM_001433225.1 → NP_001420154.1  phospholipid transfer protein C2CD2L isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    4. NM_001433226.1 → NP_001420155.1  phospholipid transfer protein C2CD2L isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    5. NM_001433227.1 → NP_001420156.1  phospholipid transfer protein C2CD2L isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    6. NM_001433228.1 → NP_001420157.1  phospholipid transfer protein C2CD2L isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A0G2K2V4

    7. NM_001433229.1 → NP_001420158.1  phospholipid transfer protein C2CD2L isoform 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    8. NM_001433230.1 → NP_001420159.1  phospholipid transfer protein C2CD2L isoform 8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    9. NM_001433231.1 → NP_001420160.1  phospholipid transfer protein C2CD2L isoform 9

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    10. NM_001433232.1 → NP_001420161.1  phospholipid transfer protein C2CD2L isoform 10

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    11. NM_001433233.1 → NP_001420162.1  phospholipid transfer protein C2CD2L isoform 11

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      53544887..53557127 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242919.5 → XP_006242981.1  phospholipid transfer protein C2CD2L isoform X3

      Conserved Domains (1) summary
      cl14603
      Location:288 → 412
      C2; C2 domain

    2. XM_006242918.5 → XP_006242980.1  phospholipid transfer protein C2CD2L isoform X2

      Conserved Domains (1) summary
      cl14603
      Location:288 → 412
      C2; C2 domain

    3. XM_006242917.5 → XP_006242979.1  phospholipid transfer protein C2CD2L isoform X1

      Related
      ENSRNOP00000036065.5, ENSRNOT00000030745.8
      Conserved Domains (1) summary
      cl14603
      Location:288 → 412
      C2; C2 domain

    4. XM_063265107.1 → XP_063121177.1  phospholipid transfer protein C2CD2L isoform X4

    5. XM_063265110.1 → XP_063121180.1  phospholipid transfer protein C2CD2L isoform X8

    6. XM_063265109.1 → XP_063121179.1  phospholipid transfer protein C2CD2L isoform X7

    7. XM_063265108.1 → XP_063121178.1  phospholipid transfer protein C2CD2L isoform X6

      Related
      ENSRNOP00000072391.1, ENSRNOT00000083490.3

    8. XM_006242920.5 → XP_006242982.1  phospholipid transfer protein C2CD2L isoform X5

      Conserved Domains (1) summary
      cl14603
      Location:288 → 412
      C2; C2 domain
    Nucleotide Protein Strain
    Heading Accession and Version

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