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    Snx7 sorting nexin 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310815, updated on 2-Nov-2024

    Summary

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    Symbol
    Snx7provided by RGD
    Full Name
    sorting nexin 7provided by RGD
    Primary source
    RGD:1305480
    See related
    AllianceGenome:RGD:1305480
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in several processes, including endocytic recycling; macroautophagy; and positive regulation of autophagosome assembly. Predicted to be located in early endosome membrane. Predicted to be active in early endosome and phagophore assembly site. Orthologous to human SNX7 (sorting nexin 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 153.5), Lung (RPKM 110.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Snx7 in Genome Data Viewer
    Location:
    2q42
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (208528041..208612597, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (205843164..205927737, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (221015302..221099810, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene phospholipid phosphatase related 4 Neighboring gene phospholipid phosphatase related 5 Neighboring gene uncharacterized LOC134485953 Neighboring gene uncharacterized LOC102549046

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in piecemeal microautophagy of the nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in reticulophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sorting nexin-7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012083.1 → NP_001012083.1  sorting nexin-7

      See identical proteins and their annotated locations for NP_001012083.1

      Status: PROVISIONAL

      Source sequence(s)
      BC082033
      UniProtKB/TrEMBL
      F7EXP7, Q66H41
      Conserved Domains (2) summary
      cd07284
      Location:32 → 147
      PX_SNX7; The phosphoinositide binding Phox Homology domain of Sorting Nexin 7
      cd07666
      Location:131 → 373
      BAR_SNX7; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      208528041..208612597 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102434.2 → XP_038958362.1  sorting nexin-7 isoform X1

      UniProtKB/TrEMBL
      F7EXP7
      Conserved Domains (2) summary
      cd07284
      Location:110 → 225
      PX_SNX7; The phosphoinositide binding Phox Homology domain of Sorting Nexin 7
      cl12013
      Location:209 → 389
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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