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    Syt3 synaptotagmin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25731, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Syt3provided by RGD
    Official Full Name
    synaptotagmin 3provided by RGD
    Primary source
    RGD:3805
    See related
    EnsemblRapid:ENSRNOG00000019318 AllianceGenome:RGD:3805
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SIII
    Summary
    Enables clathrin binding activity; phospholipid binding activity; and syntaxin binding activity. Involved in positive regulation of vesicle fusion; regulation of calcium ion-dependent exocytosis; and response to calcium ion. Is active in synaptic membrane. Orthologous to human SYT3 (synaptotagmin 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 85.2), Heart (RPKM 12.8) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Syt3 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (104017341..104032046)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (94880835..94895518)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (100379236..100407862)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene C-type lectin domain containing 11A Neighboring gene SH3 and multiple ankyrin repeat domains 1 Neighboring gene simlar to human chromosome 19 open reading frame 81 Neighboring gene uncharacterized LOC108349570 Neighboring gene leucine rich repeat containing 4B Neighboring gene aspartate dehydrogenase domain containing

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Synaptotagmin III is a novel isoform of rat synaptotagmin expressed in endocrine and neuronal cells. Mizuta M, et al. J Biol Chem, 1994 Apr 22. PMID 8163462
    2. Crystal structure of the cytosolic C2A-C2B domains of synaptotagmin III. Implications for Ca(+2)-independent snare complex interaction. Sutton RB, et al. J Cell Biol, 1999 Nov 1. PMID 10545502, Free PMC Article
    3. The subcellular localizations of atypical synaptotagmins III and VI. Synaptotagmin III is enriched in synapses and synaptic plasma membranes but not in synaptic vesicles. Butz S, et al. J Biol Chem, 1999 Jun 25. PMID 10373432
    4. Lymph node mapping in patients with bladder cancer undergoing radical cystectomy and lymph node dissection to the level of the inferior mesenteric artery. Jensen JB, et al. BJU Int, 2010 Jul. PMID 20002670
    5. Analysis of the synaptotagmin family during reconstituted membrane fusion. Uncovering a class of inhibitory isoforms. Bhalla A, et al. J Biol Chem, 2008 Aug 1. PMID 18508778, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNARE binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables calcium ion sensor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium-dependent phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables clathrin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylserine binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables syntaxin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium-ion regulated exocytosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of dendrite extension IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of dendrite extension ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of vesicle fusion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of calcium ion-dependent exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of calcium ion-dependent exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to calcium ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic vesicle exocytosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synaptic membrane EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in transport vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    synaptotagmin-3
    Names
    synaptotagmin III
    sytIII

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019122.1 → NP_061995.1  synaptotagmin-3

      See identical proteins and their annotated locations for NP_061995.1

      Status: PROVISIONAL

      Source sequence(s)
      D28512
      UniProtKB/Swiss-Prot
      P40748, Q925B7
      UniProtKB/TrEMBL
      B1AC44
      Conserved Domains (2) summary
      cd08385
      Location:297 → 422
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08403
      Location:431 → 565
      C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      104017341..104032046
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282293.1 → XP_063138363.1  synaptotagmin-3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JSR2, A6JAN7

    2. XM_039102286.2 → XP_038958214.1  synaptotagmin-3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JSR2, A6JAN7, B1AC44
      Conserved Domains (2) summary
      cd08385
      Location:297 → 422
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08403
      Location:431 → 565
      C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

    3. XM_063282281.1 → XP_063138351.1  synaptotagmin-3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JSR2, A6JAN7
      Related
      ENSRNOP00000026251.2, ENSRNOT00000026251.6

    4. XM_039102263.2 → XP_038958191.1  synaptotagmin-3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JSR2, A6JAN7, B1AC44
      Conserved Domains (2) summary
      cd08385
      Location:297 → 422
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08403
      Location:431 → 565
      C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

    5. XM_039102277.1 → XP_038958205.1  synaptotagmin-3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JSR2, A6JAN7, B1AC44
      Conserved Domains (2) summary
      cd08385
      Location:297 → 422
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08403
      Location:431 → 565
      C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

    6. XM_006228979.5 → XP_006229041.1  synaptotagmin-3 isoform X1

      See identical proteins and their annotated locations for XP_006229041.1

      UniProtKB/TrEMBL
      A0A0G2JSR2, A6JAN7, B1AC44
      Conserved Domains (2) summary
      cd08385
      Location:297 → 422
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08403
      Location:431 → 565
      C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

    7. XM_063282299.1 → XP_063138369.1  synaptotagmin-3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JSR2, A6JAN7

    8. XM_063282307.1 → XP_063138377.1  synaptotagmin-3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JSR2, A6JAN7
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40748.1 GenPept UniProtKB/Swiss-Prot:P40748

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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