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    Thap12 THAP domain containing 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308845, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Thap12provided by RGD
    Official Full Name
    THAP domain containing 12provided by RGD
    Primary source
    RGD:1309679
    See related
    EnsemblRapid:ENSRNOG00000053923 AllianceGenome:RGD:1309679
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Prkrir
    Summary
    Predicted to enable DNA binding activity and protein dimerization activity. Predicted to be located in nucleus. Orthologous to human THAP12 (THAP domain containing 12). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 190.4), Thymus (RPKM 168.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Thap12 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (162414781..162430560)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (153003605..153019386)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (163663090..163679191)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene EMSY transcriptional repressor, BRCA2 interacting Neighboring gene uncharacterized LOC134483759 Neighboring gene uncharacterized LOC134484909 Neighboring gene transfer RNA proline (anticodon UGG) 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis. Lin Y, et al. J Biol Chem, 2002 Dec 13. PMID 12384512

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    52 kDa repressor of the inhibitor of the protein kinase
    Names
    protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191630.2 → NP_001178559.1  52 kDa repressor of the inhibitor of the protein kinase

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2K8V6
      Related
      ENSRNOP00000074752.2, ENSRNOT00000088873.3
      Conserved Domains (3) summary
      pfam05485
      Location:6 → 86
      THAP; THAP domain
      pfam05699
      Location:668 → 725
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region
      pfam14291
      Location:153 → 326
      DUF4371; Domain of unknown function (DUF4371)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      162414781..162430560
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039113219.1 → XP_038969147.1  52 kDa repressor of the inhibitor of the protein kinase isoform X1

      Conserved Domains (2) summary
      pfam05699
      Location:497 → 554
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region
      pfam14291
      Location:3 → 155
      DUF4371; Domain of unknown function (DUF4371)
    Nucleotide Protein Strain
    Heading Accession and Version

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