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    Dph5 diphthamide biosynthesis 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295394, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Dph5provided by RGD
    Official Full Name
    diphthamide biosynthesis 5provided by RGD
    Primary source
    RGD:1307867
    See related
    EnsemblRapid:ENSRNOG00000013719 AllianceGenome:RGD:1307867
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CGI-30; RGD1307867
    Summary
    Predicted to enable diphthine synthase activity. Predicted to be involved in methylation and peptidyl-diphthamide biosynthetic process from peptidyl-histidine. Orthologous to human DPH5 (diphthamide biosynthesis 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 66.0), Liver (RPKM 51.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dph5 in Genome Data Viewer
    Location:
    2q42
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (206489556..206540590)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (203804620..203858196)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (218834034..218866763)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548358 Neighboring gene uncharacterized LOC120100612 Neighboring gene solute carrier family 30 member 7 Neighboring gene uncharacterized LOC120100923 Neighboring gene exostosin-like glycosyltransferase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The post-translational trimethylation of diphthamide studied in vitro. Moehring JM, et al. J Biol Chem, 1988 Mar 15. PMID 3346227
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109155

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables diphthine methyl ester synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diphthine methyl ester synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein histidyl modification to diphthamide IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    diphthine methyl ester synthase
    Names
    DPH5 homolog
    diphthine synthase
    NP_001017449.1
    XP_006233276.1
    XP_038958011.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017449.1 → NP_001017449.1  diphthine methyl ester synthase

      See identical proteins and their annotated locations for NP_001017449.1

      Status: PROVISIONAL

      Source sequence(s)
      BC092598
      UniProtKB/TrEMBL
      A0A8I5ZL86, F7F6W5, Q569A7
      Related
      ENSRNOP00000018367.5, ENSRNOT00000018367.7
      Conserved Domains (1) summary
      PTZ00175
      Location:1 → 272
      PTZ00175; diphthine synthase; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      206489556..206540590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233214.3 → XP_006233276.1  diphthine methyl ester synthase isoform X1

      See identical proteins and their annotated locations for XP_006233276.1

      UniProtKB/TrEMBL
      A0A8I5ZL86, F7F6W5, Q569A7
      Conserved Domains (1) summary
      PTZ00175
      Location:1 → 272
      PTZ00175; diphthine synthase; Provisional

    2. XM_039102083.2 → XP_038958011.1  diphthine methyl ester synthase isoform X2

      UniProtKB/TrEMBL
      A6HV83
      Conserved Domains (1) summary
      cl00304
      Location:1 → 176
      TP_methylase; S-AdoMet-dependent tetrapyrrole methylases
    Nucleotide Protein Strain
    Heading Accession and Version

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