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    Tg thyroglobulin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24826, updated on 2-Nov-2024

    Summary

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    Symbol
    Tgprovided by RGD
    Full Name
    thyroglobulinprovided by RGD
    Primary source
    RGD:3848
    See related
    EnsemblRapid:ENSRNOG00000082126 AllianceGenome:RGD:3848
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tgn
    Summary
    Enables several functions, including anion binding activity; identical protein binding activity; and protein-folding chaperone binding activity. Involved in several processes, including cellular response to genistein; response to lipopolysaccharide; and thyroid hormone generation. Located in extracellular space and perinuclear region of cytoplasm. Part of protein-containing complex. Used to study hypothyroidism and isolated growth hormone deficiency. Human ortholog(s) of this gene implicated in autoimmune disease of endocrine system (multiple); goiter; liver disease (multiple); and thyroid dyshormonogenesis 3. Orthologous to human TG (thyroglobulin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 16.1), Kidney (RPKM 5.4) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    7q33
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (100307349..100492246)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (98418293..98603210)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (107467260..107652897)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene PHD finger protein 20-like 1 Neighboring gene U2 spliceosomal RNA Neighboring gene src-like adaptor Neighboring gene cellular communication network factor 4 Neighboring gene N-myc downstream regulated 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The complete structure of the rat thyroglobulin gene. Musti AM, et al. Proc Natl Acad Sci U S A, 1986 Jan. PMID 3455768, Free PMC Article
    2. Thyroid antibodies and tumor necrosis factor-alpha in patients with benign thyroid nodules treated by percutaneous ethanol injections. Fronio G, et al. Int J Clin Pharmacol Ther, 2005 Jan. PMID 15704609
    3. Amino acid substitutions in the thyroglobulin gene are associated with susceptibility to human and murine autoimmune thyroid disease. Ban Y, et al. Proc Natl Acad Sci U S A, 2003 Dec 9. PMID 14657345, Free PMC Article
    4. Increased sensitivity of a new assay for anti-thyroglobulin antibody detection in patients with autoimmune thyroid disease. Sapin R, et al. Clin Biochem, 2003 Nov. PMID 14636875
    5. Rescue from dwarfism by thyroid function compensation in rdw rats. Furudate S, et al. Exp Anim, 2005 Oct. PMID 16365524

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The p.Pro2232Leu variant in the ChEL domain of thyroglobulin gene causes intracellular transport disorder and congenital hypothyroidism.
      Title: The p.Pro2232Leu variant in the ChEL domain of thyroglobulin gene causes intracellular transport disorder and congenital hypothyroidism.
    2. Maintaining the thyroid gland in mutant thyroglobulin-induced hypothyroidism requires thyroid cell proliferation that must continue in adulthood.
      Title: Maintaining the thyroid gland in mutant thyroglobulin-induced hypothyroidism requires thyroid cell proliferation that must continue in adulthood.
    3. p.L571P in the linker domain of rat thyroglobulin causes intracellular retention.
      Title: p.L571P in the linker domain of rat thyroglobulin causes intracellular retention.
    4. SREBP1c and SREBP2 are transcriptional regulators of the thyroglobulin gene in thyroid cells.
      Title: Sterol regulatory element-binding proteins are transcriptional regulators of the thyroglobulin gene in thyroid cells.
    5. cathepsin H is an active participant in lysosome-mediated pre-hormone degradation, and follicular Tg stimulates mobilization of pre-hormones by activating cathepsin H-associated proteolysis pathways
      Title: Follicular thyroglobulin induces cathepsin H expression and activity in thyrocytes.
    6. Rab7 regulates CDH1 endocytosis, circular dorsal ruffles genesis, and thyroglobulin pinocytosis in a thyroid cell line.
      Title: Rab7 Regulates CDH1 Endocytosis, Circular Dorsal Ruffles Genesis, and Thyroglobulin Internalization in a Thyroid Cell Line.
    7. Tg possesses unique means of regulating cell proliferation that are dependent on miR-24 and that could conceivably be involved in the autoregulation of thyroid function by Tg.
      Title: Thyroglobulin increases thyroid cell proliferation via the suppression of specific microRNAs.
    8. A novel mutation in the thyroglobulin gene that causes goiter and dwarfism in Wistar Hannover GALAS rats.
      Title: A novel mutation in the thyroglobulin gene that causes goiter and dwarfism in Wistar Hannover GALAS rats.
    9. Aammonium perchlorate can decrease the mRNA expression levels of Tg and TPO in the thyroid.
      Title: [The effects of ammonium perchlorate on thyroid function and mRNA expression of thyroglobulin and thyroperoxidase].
    10. Compared with the control group, the TPO mRNA levels of the propylthiouracil-treated group were increased, while the Tg mRNA levels were decreased significantly.
      Title: [Effect of PTU on the expression of thyroid TPO, Tg mRNA in rats].
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables anion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-folding chaperone binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to genistein IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in hormone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in iodide transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within iodide transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of myelination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of myelination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to pH IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thyroid gland development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thyroid gland development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in thyroid hormone generation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in thyroid hormone generation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in thyroid hormone generation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thyroid hormone generation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in thyroid hormone generation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within thyroid hormone metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    thyroglobulin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270783.1 → NP_001257712.1  thyroglobulin isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A0G2JXY8, G5ENA7
      Conserved Domains (5) summary
      smart00211
      Location:1471 → 1518
      TY; Thyroglobulin type I repeats
      cd00191
      Location:96 → 161
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      pfam00135
      Location:2150 → 2671
      COesterase; Carboxylesterase family
      pfam07699
      Location:1416 → 1461
      GCC2_GCC3; GCC2 and GCC3
      cl00150
      Location:682 → 728
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

    2. NM_001270784.1 → NP_001257713.1  thyroglobulin isoform 3 precursor

      See identical proteins and their annotated locations for NP_001257713.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) consists of only the first five exons plus an alternate 3' exon compared to variant 1. The resulting isoform (3) has a much shorter and distinct C-terminus compared to isoform 1. This variant has been described in PMID:2325666.
      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I6AAP3, A6HRR7
      Related
      ENSRNOP00000089860.1, ENSRNOT00000083264.4
      Conserved Domains (1) summary
      cd00191
      Location:96 → 161
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

    3. NM_030988.2 → NP_112250.2  thyroglobulin isoform 1 precursor

      See identical proteins and their annotated locations for NP_112250.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      P06882, Q9JKY6, Q9JM94
      UniProtKB/TrEMBL
      A6HRR6, G3V6V3
      Conserved Domains (5) summary
      smart00211
      Location:1519 → 1566
      TY; Thyroglobulin type I repeats
      cd00191
      Location:96 → 161
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      pfam00135
      Location:2198 → 2719
      COesterase; Carboxylesterase family
      pfam07699
      Location:1464 → 1509
      GCC2_GCC3; GCC2 and GCC3
      cl00150
      Location:164 → 249
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      100307349..100492246
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06882.4 GenPept UniProtKB/Swiss-Prot:P06882

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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