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    Kif1c kinesin family member 1C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 113886, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Kif1cprovided by RGD
    Official Full Name
    kinesin family member 1Cprovided by RGD
    Primary source
    RGD:70928
    See related
    EnsemblRapid:ENSRNOG00000031364 AllianceGenome:RGD:70928
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP hydrolysis activity; microtubule binding activity; and plus-end-directed microtubule motor activity. Involved in anterograde neuronal dense core vesicle transport and retrograde neuronal dense core vesicle transport. Predicted to be located in Golgi apparatus. Predicted to be part of kinesin complex. Predicted to be active in several cellular components, including axon; dendrite; and microtubule. Human ortholog(s) of this gene implicated in spastic ataxia 2. Orthologous to human KIF1C (kinesin family member 1C). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 997.4), Heart (RPKM 838.2) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kif1c in Genome Data Viewer
    Location:
    10q24
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55913010..55942220)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (55414412..55444587)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (57322259..57352395)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene calmodulin binding transcription activator 2 Neighboring gene small nucleolar RNA U3 Neighboring gene inhibitor of CDK, cyclin A1 interacting protein 1 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120095132 Neighboring gene zinc finger protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The secretory epithelial cells of the choroid plexus employ a novel kinesin-related protein. Rogers KR, et al. Brain Res Mol Brain Res, 1998 Apr. PMID 9582454
    2. The secretory epithelial cells of the choroid plexus employ a novel kinesin-related protein. Rogers KR, et al. Brain Res Mol Brain Res, 1997 Nov. PMID 9427518
    3. KIF1C and new Huntingtin-interacting protein 1 binding proteins regulate rheumatoid arthritis fibroblast-like synoviocytes' phenotypes. Laragione T, et al. Front Immunol, 2024. PMID 38726004, Free PMC Article
    4. Podosome-regulating kinesin KIF1C translocates to the cell periphery in a CLASP-dependent manner. Efimova N, et al. J Cell Sci, 2014 Dec 15. PMID 25344256, Free PMC Article
    5. Molecular motor KIF1C is not essential for mouse survival and motor-dependent retrograde Golgi apparatus-to-endoplasmic reticulum transport. Nakajima K, et al. Mol Cell Biol, 2002 Feb. PMID 11784862, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KIF1C and new Huntingtin-interacting protein 1 binding proteins regulate rheumatoid arthritis fibroblast-like synoviocytes' phenotypes.
      Title: KIF1C and new Huntingtin-interacting protein 1 binding proteins regulate rheumatoid arthritis fibroblast-like synoviocytes' phenotypes.
    2. KIF1C translocation to the cell periphery intensifies and KIF1C accumulates both in the proximity of peripheral microtubules that show enrichment for the plus-tip-associated proteins CLASPs and around podosomes.
      Title: Podosome-regulating kinesin KIF1C translocates to the cell periphery in a CLASP-dependent manner.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytoskeletal motor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables plus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterograde neuronal dense core vesicle transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule-based process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in retrograde neuronal dense core vesicle transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde neuronal dense core vesicle transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of kinesin complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of microtubule associated complex TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kinesin-like protein KIF1C
    Names
    kinesin 1C
    kinesin-like protein KIF1D

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145877.2 → NP_665884.2  kinesin-like protein KIF1C

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      O35787
      UniProtKB/TrEMBL
      A6HG96
      Related
      ENSRNOP00000045754.5, ENSRNOT00000041493.5
      Conserved Domains (3) summary
      cd00060
      Location:499 → 599
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:4 → 355
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam16183
      Location:352 → 522
      Kinesin_assoc; Kinesin-associated

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      55913010..55942220
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268262.1 → XP_063124332.1  kinesin-like protein KIF1C isoform X1

      UniProtKB/TrEMBL
      A6HG96

    2. XM_006246564.5 → XP_006246626.1  kinesin-like protein KIF1C isoform X1

      See identical proteins and their annotated locations for XP_006246626.1

      UniProtKB/Swiss-Prot
      O35787
      UniProtKB/TrEMBL
      A6HG96
      Conserved Domains (3) summary
      cd00060
      Location:499 → 599
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:4 → 355
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam16183
      Location:352 → 522
      Kinesin_assoc; Kinesin-associated

    3. XM_006246565.5 → XP_006246627.1  kinesin-like protein KIF1C isoform X1

      See identical proteins and their annotated locations for XP_006246627.1

      UniProtKB/Swiss-Prot
      O35787
      UniProtKB/TrEMBL
      A6HG96
      Conserved Domains (3) summary
      cd00060
      Location:499 → 599
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:4 → 355
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam16183
      Location:352 → 522
      Kinesin_assoc; Kinesin-associated

    RNA

    1. XR_005489673.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35787.1 GenPept UniProtKB/Swiss-Prot:O35787

    Gene LinkOut

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