C1qtnf6 C1q and TNF related 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: C1qtnf6provided by RGD
Official Full Name: C1q and TNF related 6provided by RGD
Primary source: RGD:1307057
See related: EnsemblRapid:ENSRNOG00000007300 AllianceGenome:RGD:1307057
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Adiq; Ctrp6
Summary: Predicted to enable identical protein binding activity. Predicted to be part of protein-containing complex. Predicted to be active in extracellular space. Biomarker of middle cerebral artery infarction. Orthologous to human C1QTNF6 (C1q and TNF related 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 62.8), Muscle (RPKM 61.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (111958348..111964948, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (110077867..110084584, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (119746150..119752727, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protective effect of CTRP6 on cerebral ischemia/reperfusion injury by attenuating inflammation, oxidative stress and apoptosis in PC12 cells.
Title: Protective effect of CTRP6 on cerebral ischemia/reperfusion injury by attenuating inflammation, oxidative stress and apoptosis in PC12 cells.
C1q/tumor necrosis factor related protein 6 (CTRP6) is involved in gentamicin-induced acute kidney injury in rats
Title: [C1q/tumor necrosis factor related protein 6 (CTRP6) is involved in gentamicin-induced acute kidney injury in rats].
CTRP6 improves PPARgamma activation and alleviates AngII-induced hypertension and vascular endothelial dysfunction
Title: Adipokine CTRP6 improves PPARγ activation to alleviate angiotensin II-induced hypertension and vascular endothelial dysfunction in spontaneously hypertensive rats.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: complement C1q tumor necrosis factor-related protein 6

Names: C1q and tumor necrosis factor related protein 6; adiponectin q

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034932.1 → NP_001030104.1 complement C1q tumor necrosis factor-related protein 6 precursor

See identical proteins and their annotated locations for NP_001030104.1

Status: PROVISIONAL

Source sequence(s)

BC101907

UniProtKB/Swiss-Prot

Q3T1I2

UniProtKB/TrEMBL

A0A3B0ITA4, A0A8L2Q529

Related

ENSRNOP00000009551.7, ENSRNOT00000009551.9

Conserved Domains (2) summary

pfam01391
Location:82 → 121

Collagen; Collagen triple helix repeat (20 copies)

pfam00386
Location:130 → 258

C1q; C1q domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

111958348..111964948 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006241985.5 → XP_006242047.1 complement C1q tumor necrosis factor-related protein 6 isoform X2

UniProtKB/TrEMBL

A0A8I5ZML3

Related

ENSRNOP00000079384.1, ENSRNOT00000106584.2
XM_039079255.2 → XP_038935183.1 complement C1q tumor necrosis factor-related protein 6 isoform X1

UniProtKB/TrEMBL

A0A8L2Q529

Conserved Domains (2) summary

pfam00386
Location:126 → 254

C1q; C1q domain

pfam01391
Location:78 → 117

Collagen; Collagen triple helix repeat (20 copies)