Pcdha3 protocadherin alpha 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

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Official Symbol: Pcdha3provided by RGD
Official Full Name: protocadherin alpha 3provided by RGD
Primary source: RGD:620336
See related: AllianceGenome:RGD:620336
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable calcium ion binding activity. Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in membrane. Orthologous to human PCDHA3 (protocadherin alpha 3). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: not in current annotation release
Expression: Biased expression in Brain (RPKM 146.1), Lung (RPKM 100.6) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Pcdha3 in Genome Data Viewer

Location:: 18p11

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

protocadherin alpha3 performs functions unique from classic cadherins in spermatogenesis and suggest a role for protocadherin alpha3 in organizing germ cell-specific structures including the intercellular bridge, flagellum, and acrosome.
Title: Protocadherin alpha3 acts at sites distinct from classic cadherins in rat testis and sperm.

Submit: New GeneRIF Correction

General gene information

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Markers

BF389688 (e-PCR)
- UniSTS:245509

PMC312645P1 (e-PCR)
- UniSTS:272906

RH91795 (e-PCR)
- UniSTS:85819

IB766 (e-PCR)
- UniSTS:42573

WI-19540 (e-PCR)
- UniSTS:63886

NoName (e-PCR)
- UniSTS:547524

Pcdha (e-PCR), detects polymorphism
- UniSTS:547524

RH65516 (e-PCR)
- UniSTS:66009

PMC311048P1 (e-PCR)
- UniSTS:272867

PMC311048P3 (e-PCR)
- UniSTS:272869

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protocadherin alpha-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053941.1 → NP_446393.1 protocadherin alpha-3 precursor

See identical proteins and their annotated locations for NP_446393.1

Status: PROVISIONAL

Source sequence(s)

AB113386

UniProtKB/TrEMBL

M0RBC1, Q767I9

Conserved Domains (3) summary

cd11304
Location:244 → 343

Cadherin_repeat; Cadherin tandem repeat domain

pfam08266
Location:27 → 108

Cadherin_2; Cadherin-like

pfam15974
Location:791 → 934

Cadherin_tail; Cadherin C-terminal cytoplasmic tail, catenin-binding region