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    AGL8 AGAMOUS-like 8 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836212, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AGL8
    Official Full Name
    AGAMOUS-like 8
    Primary source
    TAIR:AT5G60910
    Locus tag
    AT5G60910
    See related
    Araport:AT5G60910
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AGAMOUS-like 8; FRUITFULL; FUL; MSL3.30; MSL3_30
    Summary
    MADS box gene negatively regulated by APETALA1
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    Genomic context

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    See AGL8 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    9
    Sequence:
    Chromosome: 5; NC_003076.8 (24502434..24506269, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene myb domain protein 34 Neighboring gene receptor-like protein kinase 1 Neighboring gene COBRA-like extracellular glycosyl-phosphatidyl inositol-anchored protein family Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [Regulation pattern of the FRUITFULL (FUL) gene of Arabidopsis thaliana]. Chu T, et al. Sheng Wu Gong Cheng Xue Bao, 2010 Nov. PMID 21284215
    2. The FRUITFULL MADS-box gene mediates cell differentiation during Arabidopsis fruit development. Gu Q, et al. Development, 1998 Apr. PMID 9502732
    3. AabHLH48, a novel basic helix-loop-helix transcription factor from Adonis amurensis, promotes early flowering in Arabidopsis by activating FRUITFULL expression. Feng S, et al. J Plant Physiol, 2024 Jun. PMID 38657393
    4. Genetic control of meristem arrest and life span in Arabidopsis by a FRUITFULL-APETALA2 pathway. Balanzà V, et al. Nat Commun, 2018 Feb 8. PMID 29422669, Free PMC Article
    5. Arrest, Senescence and Death of Shoot Apical Stem Cells in Arabidopsis thaliana. Wang Y, et al. Plant Cell Physiol, 2023 Mar 15. PMID 36331512

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AabHLH48, a novel basic helix-loop-helix transcription factor from Adonis amurensis, promotes early flowering in Arabidopsis by activating FRUITFULL expression.
      Title: AabHLH48, a novel basic helix-loop-helix transcription factor from Adonis amurensis, promotes early flowering in Arabidopsis by activating FRUITFULL expression.
    2. Arrest, Senescence and Death of Shoot Apical Stem Cells in Arabidopsis thaliana.
      Title: Arrest, Senescence and Death of Shoot Apical Stem Cells in Arabidopsis thaliana.
    3. SEEDSTICK Controls Arabidopsis Fruit Size by Regulating Cytokinin Levels and FRUITFULL.
      Title: SEEDSTICK Controls Arabidopsis Fruit Size by Regulating Cytokinin Levels and FRUITFULL.
    4. Data show that FRUITFULL (FUL), a MADS-box gene involved in flowering and fruit development, has a key role in promoting meristem arrest, directly and negatively regulates APETALA2 expression in the shoot apical meristem.
      Title: Genetic control of meristem arrest and life span in Arabidopsis by a FRUITFULL-APETALA2 pathway.
    5. SAUR10 is repressed by FUL in stems and inflorescence branches. SAUR10 is specifically expressed at the abaxial side of these branches and this localized activity is influenced by hormones, light conditions and by FUL, which has an effect on branch angle.
      Title: FRUITFULL controls SAUR10 expression and regulates Arabidopsis growth and architecture.
    6. The sequential formation of FUL-SVP and FUL-SOC1 heterodimers may mediate the vegetative and meristem identity transitions, counteracting the repressive effect of FLC and SVP on flowering.
      Title: Sequential action of FRUITFULL as a modulator of the activity of the floral regulators SVP and SOC1.
    7. Flowering is controlled by AGL24 partly independently of SOC1 and FUL.
      Title: AGL24 acts in concert with SOC1 and FUL during Arabidopsis floral transition.
    8. Two cis-elements were involved in the repression of FUL expression. The first intron of FUL was shown to participate in the development of carpel and stamen as an enhancer.
      Title: [Regulation pattern of the FRUITFULL (FUL) gene of Arabidopsis thaliana].
    9. Data show that LEAFY, FRUITFULL, and APETALA1 are directly activated by the microRNA-targeted transcription factor SQUAMOSA PROMOTER BINDING PROTEIN-LIKE 3 (SPL3) to control the timing of flower formation.
      Title: The microRNA-regulated SBP-Box transcription factor SPL3 is a direct upstream activator of LEAFY, FRUITFULL, and APETALA1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001085307.1
    NM_125484.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in developmental growth involved in morphogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within fruit development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within maintenance of inflorescence meristem identity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of flower development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    AGAMOUS-like 8
    NP_001078776.1
    • AGAMOUS-like 8 (AGL8); FUNCTIONS IN: sequence-specific DNA binding transcription factor activity; INVOLVED IN: positive regulation of flower development, maintenance of inflorescence meristem identity, fruit development; LOCATED IN: nucleus; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Transcription factor, K-box (InterPro:IPR002487); BEST Arabidopsis thaliana protein match is: K-box region and MADS-box transcription factor family protein (TAIR:AT1G69120.1); Has 3783 Blast hits to 3782 proteins in 618 species: Archae - 0; Bacteria - 2; Metazoa - 1; Fungi - 10; Plants - 3766; Viruses - 0; Other Eukaryotes - 4 (source: NCBI BLink).
    NP_568929.1
    • AGAMOUS-like 8 (AGL8); FUNCTIONS IN: sequence-specific DNA binding transcription factor activity; INVOLVED IN: positive regulation of flower development, maintenance of inflorescence meristem identity, fruit development; LOCATED IN: nucleus; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Transcription factor, MADS-box (InterPro:IPR002100), Transcription factor, K-box (InterPro:IPR002487); BEST Arabidopsis thaliana protein match is: K-box region and MADS-box transcription factor family protein (TAIR:AT1G69120.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      24502434..24506269 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125484.4 → NP_568929.1  AGAMOUS-like 8 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568929.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q38876
      UniProtKB/TrEMBL
      A0A178UM96, A0A5S9YFW5
      Conserved Domains (2) summary
      cd00265
      Location:2 → 79
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam01486
      Location:84 → 173
      K-box; K-box region

    2. NM_001085307.1 → NP_001078776.1  AGAMOUS-like 8 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078776.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8MRX9
      Conserved Domains (1) summary
      pfam01486
      Location:22 → 109
      K-box; K-box region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q38876.1

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