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    Akr1a1 aldo-keto reductase family 1 member A1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 78959, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Akr1a1provided by RGD
    Official Full Name
    aldo-keto reductase family 1 member A1provided by RGD
    Primary source
    RGD:68346
    See related
    EnsemblRapid:ENSRNOG00000016727 AllianceGenome:RGD:68346
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Akr1a4
    Summary
    Enables L-glucuronate reductase activity and glucuronolactone reductase activity. Involved in carboxylic acid metabolic process; cellular detoxification of aldehyde; and negative regulation of apoptotic process. Predicted to be located in apical plasma membrane. Predicted to be active in cytosol and synapse. Orthologous to human AKR1A1 (aldo-keto reductase family 1 member A1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 5068.0), Adrenal (RPKM 1749.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Akr1a1 in Genome Data Viewer
    Location:
    5q35
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (135329605..135367037, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (130092945..130130277, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (135482068..135498693, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 17 Neighboring gene nuclear autoantigenic sperm protein Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134486971 Neighboring gene peroxiredoxin 1 Neighboring gene metabolism of cobalamin associated C Neighboring gene coiled-coil domain containing 163

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel glycolysis-related gene signature that can predict the survival of patients with lung adenocarcinoma. Liu C, et al. Cell Cycle, 2019 Mar. PMID 30727821, Free PMC Article
    2. Author Correction: Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury. Zhou HL, et al. Nature, 2019 Jun. PMID 31089212
    3. Identity of a major 3-deoxyglucosone-reducing enzyme with aldehyde reductase in rat liver established by amino acid sequencing and cDNA expression. Takahashi M, et al. Gene, 1993 May 30. PMID 8500767
    4. Reductive detoxification of acrolein as a potential role for aldehyde reductase (AKR1A) in mammals. Kurahashi T, et al. Biochem Biophys Res Commun, 2014 Sep 12. PMID 25152401
    5. Mechanism of human aldehyde reductase: characterization of the active site pocket. Barski OA, et al. Biochemistry, 1995 Sep 5. PMID 7669785

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-glucuronate reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-glucuronate reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables S-nitrosoglutathione reductase (NADH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables S-nitrosoglutathione reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alcohol dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aldose reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldose reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables all-trans-retinol dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables all-trans-retinol dehydrogenase (NAD+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables allyl-alcohol dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucuronolactone reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glucuronolactone reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycerol dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylglyoxal reductase (NADPH) (acetol producing) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-glucuronate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within D-glucuronate catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in D-glucuronate catabolic process to D-xylulose 5-phosphate ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-ascorbic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within L-ascorbic acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-ascorbic acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in aldehyde catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within aldehyde catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular detoxification of aldehyde IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular detoxification of aldehyde ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in daunorubicin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in doxorubicin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    aldo-keto reductase family 1 member A1
    Names
    3-DG-reducing enzyme
    S-nitroso-CoA reductase
    alcohol dehydrogenase
    aldehyde reductase
    glucuronate reductase
    glucuronolactone reductase
    scorR
    NP_112262.1
    XP_038966744.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031000.3 → NP_112262.1  aldo-keto reductase family 1 member A1

      See identical proteins and their annotated locations for NP_112262.1

      Status: PROVISIONAL

      Source sequence(s)
      D10854
      UniProtKB/Swiss-Prot
      P51635
      UniProtKB/TrEMBL
      A0A8I6AVC9, A6JZ88
      Conserved Domains (1) summary
      cd19106
      Location:8 → 312
      AKR_AKR1A1-4; AKR1A family of aldo-keto reductase (AKR)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      135329605..135367037 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110816.2 → XP_038966744.1  aldo-keto reductase family 1 member A1 isoform X1

      UniProtKB/Swiss-Prot
      P51635
      UniProtKB/TrEMBL
      A0A8I6AVC9, A6JZ88
      Related
      ENSRNOP00000023072.3, ENSRNOT00000023072.7
      Conserved Domains (1) summary
      cd19106
      Location:8 → 312
      AKR_AKR1A1-4; AKR1A family of aldo-keto reductase (AKR)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51635.2 GenPept UniProtKB/Swiss-Prot:P51635

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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