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    Dpyd dihydropyrimidine dehydrogenase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81656, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Dpydprovided by RGD
    Official Full Name
    dihydropyrimidine dehydrogenaseprovided by RGD
    Primary source
    RGD:621218
    See related
    EnsemblRapid:ENSRNOG00000017105 AllianceGenome:RGD:621218
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables several functions, including dihydropyrimidine dehydrogenase (NADP+) activity; heterocyclic compound binding activity; and protein homodimerization activity. Involved in several processes, including circadian rhythm; pyrimidine nucleobase metabolic process; and response to glucocorticoid. Located in cytosol. Used to study colorectal cancer. Biomarker of liver disease. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; dihydropyrimidine dehydrogenase deficiency; and pancreatic cancer. Orthologous to human DPYD (dihydropyrimidine dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 653.6), Adrenal (RPKM 283.5) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dpyd in Genome Data Viewer
    Location:
    2q42
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (209293902..210159777)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (206609043..207474982)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (221823692..222694627)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L29, pseudogene 19 Neighboring gene uncharacterized LOC120100931 Neighboring gene microRNA 137 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene serine and arginine rich splicing factor 3, pseudogene 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. 3-Cyano-2,6-dihydroxypyridine (CNDP), a new potent inhibitor of dihydrouracil dehydrogenase. Tatsumi K, et al. J Biochem, 1993 Dec. PMID 8138551
    2. Cloning of rat dihydropyrimidine dehydrogenase and correlation of its mRNA increase in the rat liver with age. Kimura M, et al. J Nutr Sci Vitaminol (Tokyo), 1998 Aug. PMID 9819714
    3. Autoregulation of 5-fluorouracil metabolism. McLeod HL, et al. Eur J Cancer, 1998 Sep. PMID 9893640
    4. Dihydropyrimidine dehydrogenase activity and fluorouracil pharmacokinetics with liver damage induced by bile duct ligation in rats. Tateishi T, et al. Drug Metab Dispos, 1999 Jun. PMID 10348793
    5. Clinical implications of dihydropyrimidine dehydrogenase (DPD) deficiency in patients with severe 5-fluorouracil-associated toxicity: identification of new mutations in the DPD gene. van Kuilenburg AB, et al. Clin Cancer Res, 2000 Dec. PMID 11156223

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAD binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables FMN binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NADP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NADP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dihydropyrimidine dehydrogenase (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dihydropyrimidine dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dihydropyrimidine dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dihydropyrimidine dehydrogenase (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dihydropyrimidine dehydrogenase (NADP+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables flavin adenine dinucleotide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables iron ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables uracil binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables uracil binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CMP catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in CMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in UMP catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in beta-alanine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in circadian rhythm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in dCMP catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dCMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dUMP catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dUMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in purine nucleobase catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleobase catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pyrimidine nucleobase catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within pyrimidine nucleobase catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pyrimidine nucleobase catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to glucocorticoid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to nutrient IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to organic cyclic compound IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in thymidine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thymidine catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in thymidine catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in thymine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in thymine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thymine catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in uracil catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in uracil catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in uracil catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in uracil catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in uracil metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dihydropyrimidine dehydrogenase [NADP(+)]
    Names
    DHPDHase
    DPD
    dihydrothymine dehydrogenase
    dihydrouracil dehydrogenase
    NP_112289.2
    XP_038959141.1
    XP_038959142.1
    XP_038959143.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031027.2 → NP_112289.2  dihydropyrimidine dehydrogenase [NADP(+)]

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      O89000
      UniProtKB/TrEMBL
      A0A0G2K355
      Related
      ENSRNOP00000072507.2, ENSRNOT00000086125.3
      Conserved Domains (3) summary
      cd02940
      Location:532 → 834
      DHPD_FMN; Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and ...
      pfam14697
      Location:946 → 1004
      Fer4_21; 4Fe-4S dicluster domain
      cl40752
      Location:53 → 513
      GltD; NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      209293902..210159777
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103213.2 → XP_038959141.1  dihydropyrimidine dehydrogenase [NADP(+)] isoform X1

      Conserved Domains (2) summary
      cl21457
      Location:532 → 635
      TIM; TIM-like beta/alpha barrel domains
      cl40752
      Location:53 → 513
      GltD; NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]

    2. XM_039103214.2 → XP_038959142.1  dihydropyrimidine dehydrogenase [NADP(+)] isoform X2

      Conserved Domains (1) summary
      cl40752
      Location:53 → 512
      GltD; NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]

    3. XM_039103215.2 → XP_038959143.1  dihydropyrimidine dehydrogenase [NADP(+)] isoform X3

      Conserved Domains (1) summary
      cl40752
      Location:53 → 283
      GltD; NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]

    RNA

    1. XR_005500378.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O89000.1 GenPept UniProtKB/Swiss-Prot:O89000

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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