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    Cap2 cyclase associated actin cytoskeleton regulatory protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116653, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cap2provided by RGD
    Official Full Name
    cyclase associated actin cytoskeleton regulatory protein 2provided by RGD
    Primary source
    RGD:620310
    See related
    EnsemblRapid:ENSRNOG00000043350 AllianceGenome:RGD:620310
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin binding activity; adenylate cyclase binding activity; and identical protein binding activity. Involved in regulation of modification of postsynaptic actin cytoskeleton. Is active in glutamatergic synapse and postsynapse. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human CAP2 (cyclase associated actin cytoskeleton regulatory protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 507.1), Heart (RPKM 442.0) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cap2 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (18260462..18409681, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (18054234..18203453, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (18441614..18592866, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene nucleoporin 153 Neighboring gene uncharacterized LOC120097854 Neighboring gene family with sequence similarity 8, member A1 Neighboring gene uncharacterized LOC134482694 Neighboring gene uncharacterized LOC120097855 Neighboring gene zinc finger protein 120 like 3 Neighboring gene RNA binding motif protein 24

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cyclase-associated protein 2 dimerization regulates cofilin in synaptic plasticity and Alzheimer's disease. Pelucchi S, et al. Brain Commun, 2020. PMID 33094279, Free PMC Article
    2. An actin-binding protein, CAP, is expressed in a subset of rat taste bud cells. Ishimaru Y, et al. Neuroreport, 2001 Feb 12. PMID 11209926
    3. Differential expression of CAP and CAP2 in adult rat tissues. Swiston J, et al. Gene, 1995 Nov 20. PMID 8522189
    4. Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Munton RP, et al. Mol Cell Proteomics, 2007 Feb. PMID 17114649
    5. Identification and characterization of the BRI2 interactome in the brain. Martins F, et al. Sci Rep, 2018 Feb 23. PMID 29476059, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylate cyclase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoskeleton organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in presynaptic actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of modification of postsynaptic actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of modification of postsynaptic actin cytoskeleton IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    adenylyl cyclase-associated protein 2
    Names
    CAP 2
    CAP, adenylate cyclase-associated protein, 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053874.1 → NP_446326.1  adenylyl cyclase-associated protein 2

      See identical proteins and their annotated locations for NP_446326.1

      Status: PROVISIONAL

      Source sequence(s)
      U31935
      UniProtKB/Swiss-Prot
      P52481
      UniProtKB/TrEMBL
      A0A8L2R883, A6J714
      Related
      ENSRNOP00000062591.2, ENSRNOT00000065742.4
      Conserved Domains (2) summary
      pfam01213
      Location:7 → 65
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:323 → 475
      CAP_C; Adenylate cyclase associated (CAP) C terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      18260462..18409681 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253754.4 → XP_006253816.1  adenylyl cyclase-associated protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006253816.1

      UniProtKB/Swiss-Prot
      P52481
      UniProtKB/TrEMBL
      A0A8L2R883, A6J714
      Conserved Domains (2) summary
      pfam01213
      Location:7 → 65
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:323 → 475
      CAP_C; Adenylate cyclase associated (CAP) C terminal

    2. XM_006253753.5 → XP_006253815.1  adenylyl cyclase-associated protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006253815.1

      UniProtKB/Swiss-Prot
      P52481
      UniProtKB/TrEMBL
      A0A8L2R883, A6J714
      Conserved Domains (2) summary
      pfam01213
      Location:7 → 65
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:323 → 475
      CAP_C; Adenylate cyclase associated (CAP) C terminal

    3. XM_039095302.2 → XP_038951230.1  adenylyl cyclase-associated protein 2 isoform X1

      UniProtKB/Swiss-Prot
      P52481
      UniProtKB/TrEMBL
      A0A8L2R883, A6J714
      Conserved Domains (2) summary
      pfam01213
      Location:7 → 65
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:323 → 475
      CAP_C; Adenylate cyclase associated (CAP) C terminal
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52481.1 GenPept UniProtKB/Swiss-Prot:P52481

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