Pacsin1 protein kinase C and casein kinase substrate in neurons 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pacsin1provided by RGD
Official Full Name: protein kinase C and casein kinase substrate in neurons 1provided by RGD
Primary source: RGD:3247
See related: EnsemblRapid:ENSRNOG00000054603 AllianceGenome:RGD:3247
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables phospholipid binding activity. Involved in several processes, including plasma membrane tubulation; positive regulation of dendrite development; and regulation of postsynaptic neurotransmitter receptor internalization. Located in axon terminus; perinuclear region of cytoplasm; and plasma membrane. Is active in glutamatergic synapse and postsynaptic density membrane. Orthologous to human PACSIN1 (protein kinase C and casein kinase substrate in neurons 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 270.0), Spleen (RPKM 59.3) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (5719929..5769492)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (5718134..5768064)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (7241248..7286702)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of Synapse Weakening through Interactions of the Microtubule Associated Protein Tau with PACSIN1.
Title: Regulation of Synapse Weakening through Interactions of the Microtubule Associated Protein Tau with PACSIN1.
PACSIN1 is a versatile membrane deformation protein that links the endocytic and recycling machineries essential for dynamic AMPA receptor trafficking in neurons.
Title: PACSIN1 regulates the dynamics of AMPA receptor trafficking.
The SdpI-binding site was mapped to a proline-rich sequence of 22 amino acids within the intracellular loop of GlyRbeta.
Title: Proteomic analysis of glycine receptor β subunit (GlyRβ)-interacting proteins: evidence for syndapin I regulating synaptic glycine receptors.
PICK1 interacts with PACSIN to regulate AMPA receptor internalization and cerebellar long-term depression.
Title: PICK1 interacts with PACSIN to regulate AMPA receptor internalization and cerebellar long-term depression.
Phosphorylation of syndapin I F-BAR domain at two helix-capping motifs regulates membrane tubulation
Title: Phosphorylation of syndapin I F-BAR domain at two helix-capping motifs regulates membrane tubulation.
Syndapin I was identified as the first non-kinase substrate for CaMKK.
Title: Identification of a novel CaMKK substrate.
syndapin 1 and novel protein kinase Cepsilon (nPKCepsilon) were identified as the TP-associated proteins
Title: Biochemical characterization of tau protein and its associated syndapin 1 and protein kinase Cepsilon for their functional regulation in rat brain.
We propose syndapin and endophilin function either at different stages during SVE or in mechanistically distinct types of SVE.
Title: Syndapin I and endophilin I bind overlapping proline-rich regions of dynamin I: role in synaptic vesicle endocytosis.
in addition to a crucial role in endocytic internalization, syndapin protein complexes play an important role in endocytic receptor recycling
Title: EHD proteins associate with syndapin I and II and such interactions play a crucial role in endosomal recycling.
Syndapin has been identified as a binding partner for both neural cell adhesion molecule (NCAM)-140 and NCAM-180 isoforms in rat brain cytosol.
Title: Novel cytosolic binding partners of the neural cell adhesion molecule: mapping the binding domains of PLC gamma, LANP, TOAD-64, syndapin, PP1, and PP2A.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE095567 (e-PCR)
- UniSTS:243476

RH138881 (e-PCR)
- UniSTS:220968

AA858870 (e-PCR)
- UniSTS:243427

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytoskeletal protein binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipid binding	IDA Inferred from Direct Assay more info	PubMed
enables phospholipid binding	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament organization	IEA Inferred from Electronic Annotation more info
involved_in cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of endocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in neuron projection morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasma membrane tubulation	IBA Inferred from Biological aspect of Ancestor more info
involved_in plasma membrane tubulation	IEA Inferred from Electronic Annotation more info
involved_in plasma membrane tubulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasma membrane tubulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendrite development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of dendrite development	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to membrane	IEA Inferred from Electronic Annotation more info
involved_in protein localization to membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle endocytosis	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle endocytosis	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle endocytosis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in COPI-coated vesicle	IEA Inferred from Electronic Annotation more info
located_in COPI-coated vesicle	ISO Inferred from Sequence Orthology more info
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor ribbon synapse	IEA Inferred from Electronic Annotation more info
is_active_in photoreceptor ribbon synapse	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	ISO Inferred from Sequence Orthology more info
located_in presynaptic endocytic zone	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic endocytic zone	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in terminal bouton	HDA more info	PubMed
NOT located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein kinase C and casein kinase substrate in neurons protein 1

Names: dynamin PRD-interacting protein; dynamin proline-rich domain-interacting protein; sdpI; synaptic, dynamin-associated protein I; syndapin-1; syndapin-I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017294.1 → NP_058990.1 protein kinase C and casein kinase substrate in neurons protein 1

See identical proteins and their annotated locations for NP_058990.1

Status: PROVISIONAL

Source sequence(s)

AF104402

UniProtKB/Swiss-Prot

Q9Z0W5

UniProtKB/TrEMBL

A0A0G2JWR2

Related

ENSRNOP00000089554.2, ENSRNOT00000094726.2

Conserved Domains (2) summary

cd07680
Location:16 → 273

F-BAR_PACSIN1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1)

cd11998
Location:385 → 440

SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

5719929..5769492

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039098629.2 → XP_038954557.1 protein kinase C and casein kinase substrate in neurons protein 1 isoform X1

UniProtKB/TrEMBL

A0A0G2JWR2

Conserved Domains (2) summary

cd07680
Location:16 → 273

F-BAR_PACSIN1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1)

cd11998
Location:385 → 440

SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
XM_039098628.2 → XP_038954556.1 protein kinase C and casein kinase substrate in neurons protein 1 isoform X1

UniProtKB/TrEMBL

A0A0G2JWR2

Conserved Domains (2) summary

cd07680
Location:16 → 273

F-BAR_PACSIN1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1)

cd11998
Location:385 → 440

SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2