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    Pde1a phosphodiesterase 1A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81529, updated on 17-Aug-2024

    Summary

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    Symbol
    Pde1aprovided by RGD
    Full Name
    phosphodiesterase 1Aprovided by RGD
    Primary source
    RGD:68329
    See related
    EnsemblRapid:ENSRNOG00000054212 AllianceGenome:RGD:68329
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    3-RACEclone8phosphodiesterase1A; 3'-RACEclone8phosphodiesterase1A
    Summary
    Enables calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity. Involved in cGMP catabolic process; regulation of smooth muscle cell apoptotic process; and regulation of smooth muscle cell proliferation. Located in cytoplasm; neuronal cell body; and nucleus. Orthologous to human PDE1A (phosphodiesterase 1A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 227.2), Brain (RPKM 205.3) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pde1a in Genome Data Viewer
    Location:
    3q24
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (85152053..85432289, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (64745140..65025178, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (66803247..67263658, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ITPR interacting domain containing 2 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 1C Neighboring gene uncharacterized LOC134486399 Neighboring gene uncharacterized LOC103691836 Neighboring gene DnaJ heat shock protein family (Hsp40) member C10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PDE1A inhibition elicits cGMP-dependent relaxation of rat mesenteric arteries. Khammy MM, et al. Br J Pharmacol, 2017 Nov. PMID 28910498, Free PMC Article
    2. Decreased cGMP level contributes to increased contraction in arteries from hypertensive rats: role of phosphodiesterase 1. Giachini FR, et al. Hypertension, 2011 Mar. PMID 21282562, Free PMC Article
    3. Ca2+/calmodulin-stimulated PDE1 regulates the beta-catenin/TCF signaling through PP2A B56 gamma subunit in proliferating vascular smooth muscle cells. Jeon KI, et al. FEBS J, 2010 Dec. PMID 21078118, Free PMC Article
    4. Differential changes in the expression of cyclic nucleotide phosphodiesterase isoforms in rat brains by chronic treatment with electroconvulsive shock. Cho CH, et al. Exp Mol Med, 2000 Sep 30. PMID 11048640
    5. Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy. Miller CL, et al. Circ Res, 2009 Nov 6. PMID 19797176, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pde1a is the dominant PDE1 isoform present in vascular smooth muscle cells, and relaxation mediated by PDE1A inhibition is predominantly driven by enhanced cGMP signalling.
      Title: PDE1A inhibition elicits cGMP-dependent relaxation of rat mesenteric arteries.
    2. These results suggest that induction of PDE1A plays a critical role in cardiac fibroblast activation and cardiac fibrosis
      Title: Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart.
    3. We conclude that PDE1 activation reduces cGMP bioavailability in arteries from Ang II, contributing to increased contractile responsiveness.
      Title: Decreased cGMP level contributes to increased contraction in arteries from hypertensive rats: role of phosphodiesterase 1.
    4. findings provide direct evidence for the first time that PP2A B56gamma is a critical mediator for PDE1A in the regulation of beta-catenin signaling in proliferating VSMCs
      Title: Ca2+/calmodulin-stimulated PDE1 regulates the beta-catenin/TCF signaling through PP2A B56 gamma subunit in proliferating vascular smooth muscle cells.
    5. Expression mRNA levels of PDE1A (male > female) and PDE3B (male < female) were sex dependent in microvascular endothelial cells.
      Title: Intrinsic sex-specific differences in microvascular endothelial cell phosphodiesterases.
    6. The PDE1A-PKCalpha signaling pathway is involved in the upregulation of alpha-smooth muscle actin by TGF-beta1 in adventitial fibroblasts.
      Title: The PDE1A-PKCalpha signaling pathway is involved in the upregulation of alpha-smooth muscle actin by TGF-beta1 in adventitial fibroblasts.
    7. a novel role for Ca(2+)/CaM-stimulated PDE1, particularly PDE1A, in regulating pathological cardiomyocyte hypertrophy via a cGMP/PKG-dependent mechanism, thereby demonstrating Ca(2+) and cGMP signaling cross-talk during cardiac hypertrophy.
      Title: Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy.
    8. PDE1A is important in VSMC growth and survival and may contribute to the neointima formation in atherosclerosis and restenosis.
      Title: Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 3',5'-cyclic-GMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cGMP catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of smooth muscle cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
    Names
    3'-RACE clone 8 phosphodiesterase 1A
    3-RACE clone 8 phosphodiesterase 1A
    calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
    phosphodiesterase 1A, calmodulin-dependent
    XP_038961835.1
    XP_038961836.1
    XP_038961837.1
    XP_038961838.1
    XP_063140682.1
    XP_063140683.1
    XP_063140684.1
    XP_063140686.1
    XP_063140687.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431462.1 → NP_001418391.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    2. NM_001431463.1 → NP_001418392.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    3. NM_001431464.1 → NP_001418393.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    4. NM_001431465.1 → NP_001418394.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    5. NM_001431466.1 → NP_001418395.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    6. NM_001431467.1 → NP_001418396.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    7. NM_001431468.1 → NP_001418397.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    8. NM_001431469.1 → NP_001418398.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform d

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    9. NM_001431470.1 → NP_001418399.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform d

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    10. NM_001431471.1 → NP_001418400.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform e

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    11. NM_030871.2 → NP_110498.2  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      Related
      ENSRNOP00000087351.2, ENSRNOT00000099888.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      85152053..85432289 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284612.1 → XP_063140682.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y792
      Related
      ENSRNOP00000076926.2, ENSRNOT00000112170.2

    2. XM_039105908.2 → XP_038961836.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y792, A0A8I6A416, A6HMM1
      Conserved Domains (2) summary
      pfam00233
      Location:218 → 434
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:77 → 133
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    3. XM_039105909.2 → XP_038961837.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X4

      UniProtKB/TrEMBL
      A0A0G2K2K1, A0A8I6A5M3
      Related
      ENSRNOP00000072275.3, ENSRNOT00000090547.3
      Conserved Domains (2) summary
      pfam00233
      Location:202 → 418
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:61 → 117
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    4. XM_039105910.2 → XP_038961838.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X7

      UniProtKB/TrEMBL
      A0A0G2JZX9, A0A8I6GJQ6
      Conserved Domains (2) summary
      pfam00233
      Location:184 → 400
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:43 → 99
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    5. XM_063284613.1 → XP_063140683.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y792

    6. XM_063284617.1 → XP_063140687.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X5

      UniProtKB/TrEMBL
      A0A8I5Y792, A6HMM2

    7. XM_039105907.2 → XP_038961835.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X5

      UniProtKB/TrEMBL
      A0A8I5Y792, A6HMM2
      Conserved Domains (2) summary
      pfam00233
      Location:218 → 434
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:77 → 133
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    8. XM_063284614.1 → XP_063140684.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X6

      UniProtKB/TrEMBL
      A0A0G2K2K1, A0A8I5Y879, A6HMM4

    9. XM_063284616.1 → XP_063140686.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X8

      UniProtKB/TrEMBL
      A0A0G2JZX9
      Related
      ENSRNOP00000077769.2, ENSRNOT00000102686.2
    Nucleotide Protein Strain
    Heading Accession and Version

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