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    Pmm1 phosphomannomutase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300089, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Pmm1provided by RGD
    Official Full Name
    phosphomannomutase 1provided by RGD
    Primary source
    RGD:1310897
    See related
    EnsemblRapid:ENSRNOG00000005358 AllianceGenome:RGD:1310897
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphomannomutase activity. Predicted to be involved in mannose metabolic process and protein N-linked glycosylation. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in cytoplasm and neuronal cell body. Predicted to be active in cytosol. Orthologous to human PMM1 (phosphomannomutase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 374.2), Brain (RPKM 354.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pmm1 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (115346767..115357137, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (113466632..113477004, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (123183504..123193874, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA44 Neighboring gene nucleoporin 160 like 1 Neighboring gene cold shock domain containing C2 Neighboring gene uncharacterized LOC134479945 Neighboring gene NADH:ubiquinone oxidoreductase subunit B11B Neighboring gene uncharacterized LOC103692950 Neighboring gene desumoylating isopeptidase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The X-ray crystal structures of human alpha-phosphomannomutase 1 reveal the structural basis of congenital disorder of glycosylation type 1a. Silvaggi NR, et al. J Biol Chem, 2006 May 26. PMID 16540464
    2. Tissue distribution of the murine phosphomannomutases Pmm1 and Pmm2 during brain development. Cromphout K, et al. Eur J Neurosci, 2005 Aug. PMID 16115222
    3. miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. Tarantino C, et al. FASEB J, 2010 Sep. PMID 20439489
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC105960

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphomannomutase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in GDP-mannose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mannose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phosphomannomutase 1
    Names
    Secp53 homolog
    NP_001008324.1
    XP_017450260.1
    XP_063119391.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008323.1 → NP_001008324.1  phosphomannomutase 1

      See identical proteins and their annotated locations for NP_001008324.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086346
      UniProtKB/TrEMBL
      A6HT35, F7F8W6, Q5RK25
      Related
      ENSRNOP00000007164.4, ENSRNOT00000007164.7
      Conserved Domains (1) summary
      cd02585
      Location:15 → 253
      HAD_PMM; phosphomannomutase, similar to human PMM1 and PMM2, Saccharomyces Sec53p, and Arabidopsis thaliana PMM

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      115346767..115357137 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594771.1 → XP_017450260.1  phosphomannomutase 1 isoform X2

    2. XM_063263321.1 → XP_063119391.1  phosphomannomutase 1 isoform X1

      UniProtKB/TrEMBL
      A6HT39
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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