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    Msrb2 methionine sulfoxide reductase B2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361286, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Msrb2provided by RGD
    Official Full Name
    methionine sulfoxide reductase B2provided by RGD
    Primary source
    RGD:1306026
    See related
    EnsemblRapid:ENSRNOG00000016873 AllianceGenome:RGD:1306026
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mrsb
    Summary
    Predicted to enable actin binding activity; peptide-methionine (R)-S-oxide reductase activity; and zinc ion binding activity. Predicted to be involved in actin filament polymerization. Predicted to act upstream of or within protein repair. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Orthologous to human MSRB2 (methionine sulfoxide reductase B2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 136.5), Adrenal (RPKM 131.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Msrb2 in Genome Data Viewer
    Location:
    17q12.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (86882750..86908392)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (81974378..82000044)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (86066841..86148131)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing 3 Neighboring gene PICALM interacting mitotic regulator like 1 Neighboring gene uncharacterized LOC102556079 Neighboring gene uncharacterized LOC134482617 Neighboring gene similar to human chromosome 10 open reading frame 67 Neighboring gene pancreas associated transcription factor 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MsrB1 and MICALs regulate actin assembly and macrophage function via reversible stereoselective methionine oxidation. Lee BC, et al. Mol Cell, 2013 Aug 8. PMID 23911929, Free PMC Article
    2. Methionine sulfoxide reduction in mammals: characterization of methionine-R-sulfoxide reductases. Kim HY, et al. Mol Biol Cell, 2004 Mar. PMID 14699060, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114588

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-methionine-(R)-S-oxide reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide-methionine (R)-S-oxide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide-methionine (R)-S-oxide reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide-methionine (R)-S-oxide reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide-methionine (R)-S-oxide reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin filament polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    methionine-R-sulfoxide reductase B2, mitochondrial
    NP_001026830.1
    XP_038951891.1
    XP_038951892.1
    XP_063132729.1
    XP_063132730.1
    XP_063132731.1
    XP_063132732.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031660.2 → NP_001026830.1  methionine-R-sulfoxide reductase B2, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001026830.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      Q4FZX5
      UniProtKB/TrEMBL
      A6JMA1
      Related
      ENSRNOP00000022661.4, ENSRNOT00000022661.8
      Conserved Domains (1) summary
      cl15841
      Location:42 → 171
      SelR; SelR domain

    2. NM_001429284.1 → NP_001416213.1  methionine-R-sulfoxide reductase B2, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017

    3. NM_001429285.1 → NP_001416214.1  methionine-R-sulfoxide reductase B2, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      86882750..86908392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276662.1 → XP_063132732.1  methionine-R-sulfoxide reductase B2, mitochondrial isoform X2

    2. XM_039095964.2 → XP_038951892.1  methionine-R-sulfoxide reductase B2, mitochondrial isoform X4

      Conserved Domains (1) summary
      cl15841
      Location:42 → 91
      SelR; SelR domain

    3. XM_063276661.1 → XP_063132731.1  methionine-R-sulfoxide reductase B2, mitochondrial isoform X1

    4. XM_063276660.1 → XP_063132730.1  methionine-R-sulfoxide reductase B2, mitochondrial isoform X1

    5. XM_063276659.1 → XP_063132729.1  methionine-R-sulfoxide reductase B2, mitochondrial isoform X1

    6. XM_039095963.2 → XP_038951891.1  methionine-R-sulfoxide reductase B2, mitochondrial isoform X3

      Conserved Domains (1) summary
      pfam01641
      Location:2 → 102
      SelR; SelR domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4FZX5.1 GenPept UniProtKB/Swiss-Prot:Q4FZX5

    Gene LinkOut

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