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    Rnf213 ring finger protein 213 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303735, updated on 10-Oct-2024

    Summary

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    Official Symbol
    Rnf213provided by RGD
    Official Full Name
    ring finger protein 213provided by RGD
    Primary source
    RGD:1308168
    See related
    EnsemblRapid:ENSRNOG00000029658 AllianceGenome:RGD:1308168
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308168
    Summary
    Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in several processes, including cellular protein metabolic process; protein homooligomerization; and sprouting angiogenesis. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleolus. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human RNF213 (ring finger protein 213). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 413.6), Adrenal (RPKM 287.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rnf213 in Genome Data Viewer
    Location:
    10q32.3
    Exon count:
    71
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (105154873..105254148)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (104656329..104755669)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (108527351..108626372)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene caspase recruitment domain family, member 14 Neighboring gene N-sulfoglucosamine sulfohydrolase Neighboring gene solute carrier family 26 member 11 Neighboring gene uncharacterized LOC120095223 Neighboring gene endonuclease V Neighboring gene uncharacterized LOC103693491

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transient Global Cerebral Ischemia Induces RNF213, a Moyamoya Disease Susceptibility Gene, in Vulnerable Neurons of the Rat Hippocampus CA1 Subregion and Ischemic Cortex. Sato-Maeda M, et al. J Stroke Cerebrovasc Dis, 2017 Sep. PMID 28734662
    2. Moyamoya disease susceptibility gene RNF213 links inflammatory and angiogenic signals in endothelial cells. Ohkubo K, et al. Sci Rep, 2015 Aug 17. PMID 26278786, Free PMC Article
    3. Moyamoya disease-associated protein mysterin/RNF213 is a novel AAA+ ATPase, which dynamically changes its oligomeric state. Morito D, et al. Sci Rep, 2014 Mar 24. PMID 24658080, Free PMC Article
    4. Biochemical and Functional Characterization of RNF213 (Mysterin) R4810K, a Susceptibility Mutation of Moyamoya Disease, in Angiogenesis In Vitro and In Vivo. Kobayashi H, et al. J Am Heart Assoc, 2015 Jun 30. PMID 26126547, Free PMC Article
    5. Identification of RNF213 as a susceptibility gene for moyamoya disease and its possible role in vascular development. Liu W, et al. PLoS One, 2011. PMID 21799892, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockdown the moyamoya disease susceptibility gene, RNF213, upregulates the expression of basic fibroblast growth factor and matrix metalloproteinase-9 in bone marrow derived mesenchymal stem cells.
      Title: Knockdown the moyamoya disease susceptibility gene, RNF213, upregulates the expression of basic fibroblast growth factor and matrix metalloproteinase-9 in bone marrow derived mesenchymal stem cells.
    2. Novel signaling axis of FHOD1-RNF213-Col1alpha/Col3alpha in the pathogenesis of hypertension-induced tunica media thickening.
      Title: Novel signaling axis of FHOD1-RNF213-Col1α/Col3α in the pathogenesis of hypertension-induced tunica media thickening.
    3. Report up-regulation of the Rnf213 gene in vulnerable neurons in the hippocampus CA1 after transient global cerebral ischemia.
      Title: Transient Global Cerebral Ischemia Induces RNF213, a Moyamoya Disease Susceptibility Gene, in Vulnerable Neurons of the Rat Hippocampus CA1 Subregion and Ischemic Cortex.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid droplet formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of non-canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of non-canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sprouting angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF213
    Names
    protein ALO17
    NP_001414610.1
    XP_038943469.1
    XP_038943470.1
    XP_038943471.1
    XP_063125317.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427681.1 → NP_001414610.1  E3 ubiquitin-protein ligase RNF213

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6AKP6
      Related
      ENSRNOP00000049006.7, ENSRNOT00000044983.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      105154873..105254148
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039087541.2 → XP_038943469.1  E3 ubiquitin-protein ligase RNF213 isoform X1

      UniProtKB/TrEMBL
      F1M0R1
      Conserved Domains (5) summary
      smart00382
      Location:2427 → 2549
      AAA; ATPases associated with a variety of cellular activities
      COG5574
      Location:3931 → 4039
      PEX10; RING-finger-containing E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
      cd00162
      Location:4000 → 4038
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      pfam12773
      Location:3 → 29
      DZR; Double zinc ribbon
      cl17238
      Location:4000 → 4039
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. XM_039087542.2 → XP_038943470.1  E3 ubiquitin-protein ligase RNF213 isoform X2

      UniProtKB/TrEMBL
      F1M0R1
      Related
      ENSRNOP00000104006.1, ENSRNOT00000142479.1
      Conserved Domains (5) summary
      smart00382
      Location:2427 → 2549
      AAA; ATPases associated with a variety of cellular activities
      COG5574
      Location:3930 → 4038
      PEX10; RING-finger-containing E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
      cd00162
      Location:3999 → 4037
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      pfam12773
      Location:3 → 29
      DZR; Double zinc ribbon
      cl17238
      Location:3999 → 4038
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    3. XM_039087543.2 → XP_038943471.1  E3 ubiquitin-protein ligase RNF213 isoform X3

      UniProtKB/TrEMBL
      F1M0R1
      Related
      ENSRNOP00000095018.2, ENSRNOT00000109296.2
      Conserved Domains (5) summary
      smart00382
      Location:2384 → 2506
      AAA; ATPases associated with a variety of cellular activities
      COG5574
      Location:3888 → 3996
      PEX10; RING-finger-containing E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
      cd00162
      Location:3957 → 3995
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      pfam12773
      Location:3 → 29
      DZR; Double zinc ribbon
      cl17238
      Location:3957 → 3996
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    4. XM_063269247.1 → XP_063125317.1  E3 ubiquitin-protein ligase RNF213 isoform X1

    RNA

    1. XR_005490584.2 RNA Sequence

    2. XR_005490583.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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