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    Mknk1 MAPK interacting serine/threonine kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500526, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Mknk1provided by RGD
    Official Full Name
    MAPK interacting serine/threonine kinase 1provided by RGD
    Primary source
    RGD:1559603
    See related
    EnsemblRapid:ENSRNOG00000010381 AllianceGenome:RGD:1559603
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables protein serine/threonine kinase activity. Involved in peptidyl-serine phosphorylation and regulation of translational initiation. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human MKNK1 (MAPK interacting serine/threonine kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 76.3), Adrenal (RPKM 75.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mknk1 in Genome Data Viewer
    Location:
    5q35
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (134554881..134594392)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (129318128..129357641)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (134691852..134730887)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 1 Neighboring gene MOB kinase activator 3C Neighboring gene kinocilin Neighboring gene transmembrane protein 275

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Ras transformation of RIE-1 cells activates cap-independent translation of ornithine decarboxylase: regulation by the Raf/MEK/ERK and phosphatidylinositol 3-kinase pathways. Origanti S, et al. Cancer Res, 2007 May 15. PMID 17510413
    2. MNK1 and MNK2 regulation in HER2-overexpressing breast cancer lines. Chrestensen CA, et al. J Biol Chem, 2007 Feb 16. PMID 17130135
    3. Alterations in mammalian target of rapamycin signaling pathways after traumatic brain injury. Chen S, et al. J Cereb Blood Flow Metab, 2007 May. PMID 16955078
    4. Molecules in focus: cytosolic phospholipase A2-alpha. Niknami M, et al. Int J Biochem Cell Biol, 2009 May. PMID 18761105
    5. Loss of MNK function sensitizes fibroblasts to serum-withdrawal induced apoptosis. Chrestensen CA, et al. Genes Cells, 2007 Oct. PMID 17903173

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112775

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium/calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translational initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to salt stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    MAP kinase-interacting serine/threonine-protein kinase 1
    Names
    MAP kinase signal-integrating kinase 1
    MAP kinase-interacting serine/threonine kinase 1
    MAPK signal-integrating kinase 1
    mnk1
    NP_001037732.1
    XP_006238756.1
    XP_006238758.1
    XP_006238759.1
    XP_006238760.1
    XP_038966512.1
    XP_038966513.1
    XP_038966514.1
    XP_038966515.1
    XP_063144306.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044267.1 → NP_001037732.1  MAP kinase-interacting serine/threonine-protein kinase 1

      See identical proteins and their annotated locations for NP_001037732.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098754
      UniProtKB/Swiss-Prot
      Q4G050
      UniProtKB/TrEMBL
      A0A8L2QVH8, A6JZ51
      Conserved Domains (1) summary
      cd14174
      Location:34 → 322
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      134554881..134594392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238697.4 → XP_006238759.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2

      See identical proteins and their annotated locations for XP_006238759.1

      UniProtKB/TrEMBL
      A0A0G2K3K7, A0A8L2QVH8
      Related
      ENSRNOP00000072679.2, ENSRNOT00000091543.3
      Conserved Domains (2) summary
      smart00220
      Location:47 → 327
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14174
      Location:40 → 328
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

    2. XM_063288236.1 → XP_063144306.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X8

    3. XM_006238696.5 → XP_006238758.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2

      See identical proteins and their annotated locations for XP_006238758.1

      UniProtKB/TrEMBL
      A0A0G2K3K7, A0A8L2QVH8
      Related
      ENSRNOP00000061535.4, ENSRNOT00000067655.4
      Conserved Domains (2) summary
      smart00220
      Location:47 → 327
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14174
      Location:40 → 328
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

    4. XM_006238698.5 → XP_006238760.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X3

      See identical proteins and their annotated locations for XP_006238760.1

      UniProtKB/Swiss-Prot
      Q4G050
      UniProtKB/TrEMBL
      A0A8L2QVH8, A6JZ51
      Conserved Domains (1) summary
      cd14174
      Location:34 → 322
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

    5. XM_039110587.2 → XP_038966515.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X7

      Conserved Domains (1) summary
      cl21453
      Location:31 → 200
      PKc_like; Protein Kinases, catalytic domain

    6. XM_039110585.2 → XP_038966513.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X5

      UniProtKB/TrEMBL
      A0A8L2QVH8
      Conserved Domains (1) summary
      cd14174
      Location:40 → 328
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

    7. XM_039110586.1 → XP_038966514.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X6

      Related
      ENSRNOP00000102287.1, ENSRNOT00000138277.1
      Conserved Domains (1) summary
      cl21453
      Location:40 → 209
      PKc_like; Protein Kinases, catalytic domain

    8. XM_039110584.1 → XP_038966512.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X4

      Conserved Domains (1) summary
      cl21453
      Location:40 → 209
      PKc_like; Protein Kinases, catalytic domain

    9. XM_006238694.5 → XP_006238756.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QVH8
      Related
      ENSRNOP00000112550.1, ENSRNOT00000121912.1
      Conserved Domains (2) summary
      smart00220
      Location:74 → 354
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14174
      Location:67 → 355
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4G050.1 GenPept UniProtKB/Swiss-Prot:Q4G050

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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