Frs3 fibroblast growth factor receptor substrate 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Frs3provided by RGD
Official Full Name: fibroblast growth factor receptor substrate 3provided by RGD
Primary source: RGD:1310226
See related: EnsemblRapid:ENSRNOG00000014328 AllianceGenome:RGD:1310226
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable fibroblast growth factor receptor binding activity; identical protein binding activity; and transmembrane receptor protein tyrosine kinase adaptor activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm. Orthologous to human FRS3 (fibroblast growth factor receptor substrate 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 30.4), Brain (RPKM 26.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q12

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (20786096..20800905, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (13288559..13297285, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (15297794..15306850, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables fibroblast growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables fibroblast growth factor receptor binding	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein tyrosine kinase adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: fibroblast growth factor receptor substrate 3

Names: FGFR substrate 3; FGFR-signaling adaptor SNT2; SNT-2; suc1-associated neurotrophic factor target 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017382.2 → NP_001017382.2 fibroblast growth factor receptor substrate 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

Q52RG8

UniProtKB/TrEMBL

A6JII5, G3V7U7

Related

ENSRNOP00000019404.2, ENSRNOT00000019404.6

Conserved Domains (1) summary

cd01202
Location:15 → 106

PTB_FRS2; Fibroblast growth factor receptor substrate 2 phosphotyrosine-binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

20786096..20800905 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063267085.1 → XP_063123155.1 fibroblast growth factor receptor substrate 3 isoform X1

UniProtKB/TrEMBL

A6JII5, G3V7U7
XM_063267086.1 → XP_063123156.1 fibroblast growth factor receptor substrate 3 isoform X1

UniProtKB/TrEMBL

A6JII5, G3V7U7