Cant1 calcium activated nucleotidase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cant1provided by RGD
Official Full Name: calcium activated nucleotidase 1provided by RGD
Primary source: RGD:628743
See related: Ensembl:ENSRNOG00000003239 AllianceGenome:RGD:628743
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: srapy
Summary: Predicted to enable calcium ion binding activity; nucleoside-diphosphatase activity; and protein homodimerization activity. Predicted to be involved in positive regulation of I-kappaB kinase/NF-kappaB signaling and proteoglycan biosynthetic process. Located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Desbuquois dysplasia and multiple epiphyseal dysplasia 7. Orthologous to human CANT1 (calcium activated nucleotidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 107.0), Adrenal (RPKM 73.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (104135676..104148854, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (103637079..103650240, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (107432500..107445634, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

soluble apyrase as well as the glomerular ENTPD1 are sensitive to oxidant stress, which may explain their downregulation in the ischemic condition in vivo. However, soluble 5'-nucleotidase and E5NT seem much less sensitive to ROS
Title: Histochemical detection of ischemia-like alterations induced in kidney tissue in vitro--different sensitivity to oxidant stress of glomerular ENTPD1 versus E5NT.
results show that apyrase and 5'-nucleotidase activities are altered in demyelination events
Title: Apyrase and 5'-nucleotidase activities in synaptosomes from the cerebral cortex of rats experimentally demyelinated with ethidium bromide and treated with interferon-beta.

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General gene information

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Markers

RH133048 (e-PCR)
- UniSTS:216331

D11Bwg0554e (e-PCR), detects polymorphism
- UniSTS:141720

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ADP phosphatase activity	ISO Inferred from Sequence Orthology more info
enables GDP phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GDP phosphatase activity	ISO Inferred from Sequence Orthology more info
enables UDP phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables nucleoside diphosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info	PubMed
involved_in proteoglycan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in proteoglycan biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: soluble calcium-activated nucleotidase 1

Names: SCAN-1; apyrase homolog; ectonucleoside triphosphate diphosphohydrolase 8

NP_653355.1

EC 3.6.1.6

XP_006247851.1

EC 3.6.1.6

XP_006247852.1

EC 3.6.1.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.