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    Kank4 KN motif and ankyrin repeat domains 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313385, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Kank4provided by RGD
    Official Full Name
    KN motif and ankyrin repeat domains 4provided by RGD
    Primary source
    RGD:1307635
    See related
    EnsemblRapid:ENSRNOG00000007779 AllianceGenome:RGD:1307635
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    BC060737
    Summary
    Predicted to be involved in negative regulation of actin filament polymerization. Predicted to be located in cytosol and microtubule cytoskeleton. Predicted to be active in cytoplasm and cytoskeleton. Orthologous to human KANK4 (KN motif and ankyrin repeat domains 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 92.6), Kidney (RPKM 43.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kank4 in Genome Data Viewer
    Location:
    5q33
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (118516994..118581024, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (113401491..113465526, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (117376425..117440643, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene PATJ, crumbs cell polarity complex component Neighboring gene uncharacterized LOC134486954 Neighboring gene LINE-1 type transposase domain containing 1 Neighboring gene uncharacterized LOC134479012 Neighboring gene ubiquitin specific peptidase 15, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. KANK deficiency leads to podocyte dysfunction and nephrotic syndrome. Gee HY, et al. J Clin Invest, 2015 Jun. PMID 25961457, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in negative regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    KN motif and ankyrin repeat domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107947.1 → NP_001101417.1  KN motif and ankyrin repeat domain-containing protein 4

      See identical proteins and their annotated locations for NP_001101417.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473998
      UniProtKB/TrEMBL
      A6JRL0, D4A6X3
      Conserved Domains (5) summary
      cd00204
      Location:827 → 958
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12075
      Location:24 → 62
      KN_motif; KN motif
      pfam12796
      Location:837 → 935
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:924 → 979
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:832 → 864
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      118516994..118581024 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008763868.4 → XP_008762090.1  KN motif and ankyrin repeat domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A9C5, D4A6X3
      Related
      ENSRNOP00000061603.3, ENSRNOT00000066139.4
      Conserved Domains (5) summary
      cd00204
      Location:837 → 968
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12075
      Location:34 → 72
      KN_motif; KN motif
      pfam12796
      Location:847 → 945
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:934 → 989
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:842 → 874
      ANK; ANK repeat [structural motif]

    2. XM_039109903.2 → XP_038965831.1  KN motif and ankyrin repeat domain-containing protein 4 isoform X2

      UniProtKB/TrEMBL
      D4A6X3
      Related
      ENSRNOP00000087738.2, ENSRNOT00000095602.2
      Conserved Domains (4) summary
      TIGR02169
      Location:343 → 442
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      sd00045
      Location:842 → 874
      ANK; ANK repeat [structural motif]
      pfam12075
      Location:34 → 72
      KN_motif; KN motif
      pfam12796
      Location:919 → 980
      Ank_2; Ankyrin repeats (3 copies)

    3. XM_063287641.1 → XP_063143711.1  KN motif and ankyrin repeat domain-containing protein 4 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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