Nxt2 nuclear transport factor 2-like export factor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nxt2provided by RGD
Official Full Name: nuclear transport factor 2-like export factor 2provided by RGD
Primary source: RGD:1560204
See related: EnsemblRapid:ENSRNOG00000019168 AllianceGenome:RGD:1560204
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1560204
Summary: Predicted to be involved in protein import into nucleus. Predicted to be located in cytosol; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be part of nuclear pore central transport channel. Orthologous to human NXT2 (nuclear transport factor 2 like export factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 59.6), Liver (RPKM 52.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq33

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (110652434..110659738)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (105855616..105862902)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (113509841..113517112)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic characterization of nuclear export factor NXT1 and its paralog NXT2 in primates and murine rodents.
Title: Genetic characterization of nuclear export factor NXT1 and its paralog NXT2 in primates and murine rodents.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in nucleocytoplasmic transport	IEA Inferred from Electronic Annotation more info
involved_in poly(A)+ mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of nuclear RNA export factor complex	IEA Inferred from Electronic Annotation more info
part_of nuclear RNA export factor complex	ISO Inferred from Sequence Orthology more info
part_of nuclear pore central transport channel	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: NTF2-related export protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108120.1 → NP_001101590.1 NTF2-related export protein 2

See identical proteins and their annotated locations for NP_001101590.1

Status: PROVISIONAL

Source sequence(s)

CH474047

UniProtKB/Swiss-Prot

B2GV77

Conserved Domains (1) summary

cd00780
Location:13 → 138

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

110652434..110659738

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006257360.5 → XP_006257422.1 NTF2-related export protein 2 isoform X1

UniProtKB/TrEMBL

A0A8I5ZTZ1

Related

ENSRNOP00000081934.1, ENSRNOT00000103549.2

Conserved Domains (1) summary

cd00780
Location:69 → 194

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
XM_006257361.5 → XP_006257423.1 NTF2-related export protein 2 isoform X2

UniProtKB/TrEMBL

A0A140TAD4

Related

ENSRNOP00000025912.7, ENSRNOT00000025912.9

Conserved Domains (1) summary

cd00780
Location:43 → 168

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
XM_008773417.4 → XP_008771639.1 NTF2-related export protein 2 isoform X3

See identical proteins and their annotated locations for XP_008771639.1

UniProtKB/TrEMBL

A6KG69

Related

ENSRNOP00000099604.1, ENSRNOT00000163771.1

Conserved Domains (1) summary

cd00780
Location:5 → 130

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...