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    Slc66a1 solute carrier family 66 member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362642, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Slc66a1provided by RGD
    Official Full Name
    solute carrier family 66 member 1provided by RGD
    Primary source
    RGD:1311627
    See related
    EnsemblRapid:ENSRNOG00000017706 AllianceGenome:RGD:1311627
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pqlc2
    Summary
    Enables basic amino acid transmembrane transporter activity. Involved in amino acid homeostasis. Located in lysosomal membrane. Orthologous to human SLC66A1 (solute carrier family 66 member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 50.5), Kidney (RPKM 36.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc66a1 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (156821084..156835558, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (151537870..151552259, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (157744945..157759370, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134487024 Neighboring gene capping actin protein of muscle Z-line subunit beta Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene aldo-keto reductase family 7, member A2 Neighboring gene ribosomal protein L9, pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. LAAT-1 is the lysosomal lysine/arginine transporter that maintains amino acid homeostasis. Liu B, et al. Science, 2012 Jul 20. PMID 22822152, Free PMC Article
    2. Heptahelical protein PQLC2 is a lysosomal cationic amino acid exporter underlying the action of cysteamine in cystinosis therapy. Jézégou A, et al. Proc Natl Acad Sci U S A, 2012 Dec 11. PMID 23169667, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-arginine transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-arginine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-histidine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-lysine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-lysine transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-lysine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables basic amino acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-arginine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-arginine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-histidine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-lysine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-lysine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular amino acid homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular amino acid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular amino acid homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lysine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lysine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in organelle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    lysosomal amino acid transporter 1 homolog
    Names
    PQ loop repeat containing 2
    PQ-loop repeat-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399232.1 → NP_001386161.1  lysosomal amino acid transporter 1 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8L2QDE2
      Related
      ENSRNOP00000023896.7, ENSRNOT00000023896.9

    2. NM_001399233.1 → NP_001386162.1  lysosomal amino acid transporter 1 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      B0BMY1, F7FC79
      UniProtKB/TrEMBL
      A0A8I5Y800
      Conserved Domains (1) summary
      pfam04193
      Location:183 → 238
      PQ-loop; PQ loop repeat

    3. NM_001399234.1 → NP_001386163.1  lysosomal amino acid transporter 1 homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      Related
      ENSRNOP00000107028.1, ENSRNOT00000157253.1

    RNA

    1. NR_174173.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      Related
      ENSRNOT00000099105.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      156821084..156835558 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017593523.3 → XP_017449012.1  lysosomal amino acid transporter 1 homolog isoform X2

      Conserved Domains (1) summary
      pfam04193
      Location:170 → 224
      PQ-loop; PQ loop repeat

    2. XM_006239239.5 → XP_006239301.1  lysosomal amino acid transporter 1 homolog isoform X1

      See identical proteins and their annotated locations for XP_006239301.1

      UniProtKB/Swiss-Prot
      B0BMY1, F7FC79
      UniProtKB/TrEMBL
      A0A8I5Y800
      Conserved Domains (1) summary
      pfam04193
      Location:183 → 238
      PQ-loop; PQ loop repeat

    3. XM_063288076.1 → XP_063144146.1  lysosomal amino acid transporter 1 homolog isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108689.2: Suppressed sequence

      Description
      NM_001108689.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B0BMY1.1 GenPept UniProtKB/Swiss-Prot:B0BMY1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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