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    Ankrd13b ankyrin repeat domain 13B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360575, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Ankrd13bprovided by RGD
    Official Full Name
    ankyrin repeat domain 13Bprovided by RGD
    Primary source
    RGD:1564005
    See related
    EnsemblRapid:ENSRNOG00000014742 AllianceGenome:RGD:1564005
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564005
    Summary
    Predicted to enable ubiquitin-dependent protein binding activity. Predicted to be involved in negative regulation of receptor internalization. Predicted to be located in endosome; perinuclear region of cytoplasm; and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human ANKRD13B (ankyrin repeat domain 13B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 45.3), Lung (RPKM 25.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ankrd13b in Genome Data Viewer
    Location:
    10q24
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (62817791..62836456, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (62319660..62338342, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (62674416..62691949)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene slingshot protein phosphatase 2 Neighboring gene uncharacterized LOC134480826 Neighboring gene uncharacterized LOC120095265 Neighboring gene coronin 6 Neighboring gene GIT ArfGAP 1 Neighboring gene tumor protein p53 inducible protein 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane. Tanno H, et al. Mol Biol Cell, 2012 Apr. PMID 22298428, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin-modified protein reader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 13B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430227.1 → NP_001417156.1  ankyrin repeat domain-containing protein 13B

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      D4A6I3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      62817791..62836456 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008768134.4 → XP_008766356.1  ankyrin repeat domain-containing protein 13B isoform X2

      See identical proteins and their annotated locations for XP_008766356.1

      UniProtKB/TrEMBL
      D4A1M1
      Conserved Domains (4) summary
      cd00204
      Location:13 → 105
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam11904
      Location:163 → 490
      GPCR_chapero_1; GPCR-chaperone
      pfam13857
      Location:34 → 88
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:13 → 45
      ANK; ANK repeat [structural motif]

    2. XM_008768135.4 → XP_008766357.1  ankyrin repeat domain-containing protein 13B isoform X1

      See identical proteins and their annotated locations for XP_008766357.1

      UniProtKB/TrEMBL
      D4A1M1
      Related
      ENSRNOP00000052960.3, ENSRNOT00000056110.5
      Conserved Domains (4) summary
      cd00204
      Location:13 → 105
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam11904
      Location:163 → 490
      GPCR_chapero_1; GPCR-chaperone
      pfam13857
      Location:34 → 88
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:13 → 45
      ANK; ANK repeat [structural motif]

    3. XM_008768137.4 → XP_008766359.1  ankyrin repeat domain-containing protein 13B isoform X3

      Related
      ENSRNOP00000111276.1, ENSRNOT00000145817.1
      Conserved Domains (4) summary
      cd00204
      Location:13 → 105
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam11904
      Location:163 → 490
      GPCR_chapero_1; GPCR-chaperone
      pfam13857
      Location:34 → 88
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:13 → 45
      ANK; ANK repeat [structural motif]

    4. XM_008768138.4 → XP_008766360.1  ankyrin repeat domain-containing protein 13B isoform X3

      See identical proteins and their annotated locations for XP_008766360.1

      UniProtKB/TrEMBL
      D4A6I3
      Conserved Domains (4) summary
      cd00204
      Location:13 → 105
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam11904
      Location:163 → 490
      GPCR_chapero_1; GPCR-chaperone
      pfam13857
      Location:34 → 88
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:13 → 45
      ANK; ANK repeat [structural motif]

    5. XM_017597656.3 → XP_017453145.1  ankyrin repeat domain-containing protein 13B isoform X3

      UniProtKB/TrEMBL
      D4A6I3
      Conserved Domains (4) summary
      cd00204
      Location:13 → 105
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam11904
      Location:163 → 490
      GPCR_chapero_1; GPCR-chaperone
      pfam13857
      Location:34 → 88
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:13 → 45
      ANK; ANK repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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