Olig2 oligodendrocyte transcription factor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Olig2provided by RGD
Official Full Name: oligodendrocyte transcription factor 2provided by RGD
Primary source: RGD:1307098
See related: EnsemblRapid:ENSRNOG00000028658 AllianceGenome:RGD:1307098
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; HMG box domain binding activity; and identical protein binding activity. Involved in oligodendrocyte differentiation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Biomarker of status epilepticus. Orthologous to human OLIG2 (oligodendrocyte transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 52.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 11q11

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (43961585..43964961)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (30475510..30478886)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (31389514..31392890)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Oligodendrocyte Transcription Factor 2 OLIG2 regulates transcriptional repression during myelinogenesis in rodents.
Title: The Oligodendrocyte Transcription Factor 2 OLIG2 regulates transcriptional repression during myelinogenesis in rodents.
these data strongly suggest that bone marrow stromal cells (BMSCs) can promote the differentiation of Neural stem cells (NSCs) into oligodendrocytes through mediating Id2 and Olig1/2 expression by blocking the BMP/Smad signaling pathway
Title: BMSCs promote the differentiation of NSCs into oligodendrocytes via mediating Id2 and Olig expression through BMP/Smad signaling pathway.
Replacing heregulin, PDGF-AA and bFGF with T3 for 6 days resulted in repression of O4, O1, Olig2 and PDGFR-a
Title: Differentiation of neurosphere-derived rat neural stem cells into oligodendrocyte-like cells by repressing PDGF-α and Olig2 with triiodothyronine.
Olig1 and Olig2 expression are enhanced during antipsychotic drug induced differentiation of oligodendrocyte progenitor cells.
Title: Antipsychotics promote the differentiation of oligodendrocyte progenitor cells by regulating oligodendrocyte lineage transcription factors 1 and 2.
Olig2 overexpression enhances oligodendrocyte differentiation and myelination with an effect on functional recovery following spinal cord injury.
Title: Effects of Olig2-overexpressing neural stem cells and myelin basic protein-activated T cells on recovery from spinal cord injury.
Study finds that the oligodendrocyte-lineage determination factor Olig2 transcriptionally prepatterns the chromatin-remodeling factor Smarca4/Brg1 to the enhancer elements to control oligodendrocyte differentiation.
Title: Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation.
Pax6 decreases the number of Neuron-Glia 2 progenitor cells and prevents oligodendrocytic lineage commitment, while repression of Olig2 results in an expanded astrocytic lineage.
Title: Modification of pax6 and olig2 expression in adult hippocampal neurogenesis selectively induces stem cell fate and alters both neuronal and glial populations.
Our data provided in-vivo evidence that NG2+ progenitors can give rise to both astrocytes and oligodendrocytes in response to injury, and their fate choice was associated with cytoplasmic translocation or nuclear retention of Olig2, respectively.
Title: Astrocytes and oligodendrocytes can be generated from NG2+ progenitors after acute brain injury: intracellular localization of oligodendrocyte transcription factor 2 is associated with their fate choice.
Smad-containing transcriptional complexes may be involved in direct regulation of the Olig2 promoter.
Title: Induction of Olig2 precursors by FGF involves BMP signalling blockade at the Smad level.
Overexpression of olig1 and olig2 inhibits astrocyte differentiation and promotes oligodendrocyte differentiation of adult oligodendrocyte precursor cells.
Title: Bone morphogenetic protein signaling and olig1/2 interact to regulate the differentiation and maturation of adult oligodendrocyte precursor cells.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Markers

Olig2 (e-PCR), detects polymorphism
- UniSTS:259114

AU025128 (e-PCR)
- UniSTS:115569

D21S392 (e-PCR)
- UniSTS:147861

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables E-box binding	IBA Inferred from Biological aspect of Ancestor more info
enables HMG box domain binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in axon development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within myelination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron fate commitment	ISO Inferred from Sequence Orthology more info
involved_in oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within spinal cord motor neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spinal cord oligodendrocyte cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spinal cord oligodendrocyte cell fate specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within thalamus development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: oligodendrocyte transcription factor 2

Names: oligodendrocyte lineage transcription factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100557.1 → NP_001094027.1 oligodendrocyte transcription factor 2

See identical proteins and their annotated locations for NP_001094027.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/TrEMBL

A6JLE7, G3V612

Related

ENSRNOP00000109314.1, ENSRNOT00000128533.1

Conserved Domains (1) summary

cd18940
Location:95 → 179

bHLH_TS_OLIG2; basic helix-loop-helix (bHLH) domain found in oligodendrocyte transcription factor 2 (Oligo2) and similar proteins