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    Zfp512b zinc finger protein 512B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311721, updated on 10-Oct-2024

    Summary

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    Official Symbol
    Zfp512bprovided by RGD
    Official Full Name
    zinc finger protein 512Bprovided by RGD
    Primary source
    RGD:1305284
    See related
    EnsemblRapid:ENSRNOG00000015558 AllianceGenome:RGD:1305284
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Urkl1; Znf512b
    Summary
    Predicted to enable kinase activity. Predicted to be involved in phosphorylation. Predicted to be located in nucleoplasm. Orthologous to human ZNF512B (zinc finger protein 512B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 71.9), Kidney (RPKM 67.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp512b in Genome Data Viewer
    Location:
    3q43
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (189065036..189075587, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (168687520..168698067, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (177078708..177089210, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548047 Neighboring gene DnaJ heat shock protein family (Hsp40) member C5 Neighboring gene uridine-cytidine kinase 1-like 1 Neighboring gene sterile alpha motif domain containing 10 Neighboring gene pre-mRNA processing factor 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Key role of uridine kinase and uridine phosphorylase in the homeostatic regulation of purine and pyrimidine salvage in brain. Balestri F, et al. Neurochem Int, 2007 Dec. PMID 17643556
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of miRNA transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 512B
    Names
    uridine kinase-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107809.1 → NP_001101279.1  zinc finger protein 512B

      See identical proteins and their annotated locations for NP_001101279.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474066
      UniProtKB/TrEMBL
      A6KLZ0, D3ZJ29
      Related
      ENSRNOP00000020873.5, ENSRNOT00000020873.6
      Conserved Domains (2) summary
      sd00017
      Location:579 → 600
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15926
      Location:437 → 521
      RNF220; E3 ubiquitin-protein ligase RNF220

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      189065036..189075587 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283902.1 → XP_063139972.1  zinc finger protein 512B isoform X8

    2. XM_063283900.1 → XP_063139970.1  zinc finger protein 512B isoform X6

    3. XM_063283897.1 → XP_063139967.1  zinc finger protein 512B isoform X1

    4. XM_063283899.1 → XP_063139969.1  zinc finger protein 512B isoform X5

    5. XM_063283898.1 → XP_063139968.1  zinc finger protein 512B isoform X4

    6. XM_039105152.2 → XP_038961080.1  zinc finger protein 512B isoform X2

      UniProtKB/TrEMBL
      D3ZJ29
      Conserved Domains (2) summary
      PHA03247
      Location:265 → 624
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:739 → 760
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. XM_063283901.1 → XP_063139971.1  zinc finger protein 512B isoform X7

    8. XM_039105153.2 → XP_038961081.1  zinc finger protein 512B isoform X3

      UniProtKB/TrEMBL
      A0A8I6AJD9, D3ZJ29
      Related
      ENSRNOP00000095303.1, ENSRNOT00000111216.2
      Conserved Domains (2) summary
      PHA03247
      Location:265 → 624
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:729 → 750
      ZF_C2H2; C2H2 Zn finger [structural motif]

    9. XM_063283904.1 → XP_063139974.1  zinc finger protein 512B isoform X10

    10. XM_063283903.1 → XP_063139973.1  zinc finger protein 512B isoform X9

    11. XM_063283905.1 → XP_063139975.1  zinc finger protein 512B isoform X11

    Nucleotide Protein Strain
    Heading Accession and Version

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