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    Usp44 ubiquitin specific peptidase 44 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314746, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Usp44provided by RGD
    Official Full Name
    ubiquitin specific peptidase 44provided by RGD
    Primary source
    RGD:1308216
    See related
    EnsemblRapid:ENSRNOG00000005637 AllianceGenome:RGD:1308216
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable thiol-dependent deubiquitinase. Predicted to be involved in several processes, including negative regulation of ubiquitin protein ligase activity; proteolysis; and regulation of mitotic cell cycle spindle assembly checkpoint. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human USP44 (ubiquitin specific peptidase 44). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 143.3), Spleen (RPKM 19.2) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Usp44 in Genome Data Viewer
    Location:
    7q13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (30251142..30301185)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (28364169..28412039)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (34714293..34759352)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479662 Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2 Neighboring gene methionyl aminopeptidase 2 Neighboring gene vezatin, adherens junctions transmembrane protein Neighboring gene uncharacterized LOC120093556 Neighboring gene microRNA 331

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. K48- and K63-linked polyubiquitination of deubiquitinating enzyme USP44. Suresh B, et al. Cell Biol Int, 2010 Aug. PMID 20402667
    2. Overexpression of ubiquitin specific protease 44 (USP44) induces chromosomal instability and is frequently observed in human T-cell leukemia. Zhang Y, et al. PLoS One, 2011. PMID 21853124, Free PMC Article
    3. USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis. Zhang Y, et al. J Clin Invest, 2012 Dec. PMID 23187126, Free PMC Article
    4. Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Stegmeier F, et al. Nature, 2007 Apr 19. PMID 17443180
    5. H2A-DUBbing the mammalian epigenome: expanding frontiers for histone H2A deubiquitinating enzymes in cell biology and physiology. Belle JI, et al. Int J Biochem Cell Biol, 2014 May. PMID 24647359

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in antiviral innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mitotic metaphase/anaphase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic cell cycle spindle assembly checkpoint ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulatory T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 44
    Names
    ubiquitin specific protease 44
    ubiquitin thiolesterase 44
    NP_001381000.1
    XP_038934982.1
    XP_038934983.1
    XP_038934988.1
    XP_038934989.1
    XP_038934991.1
    XP_038934996.1
    XP_063119514.1
    XP_063119515.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394071.2 → NP_001381000.1  ubiquitin carboxyl-terminal hydrolase 44

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I6A942
      Conserved Domains (2) summary
      pfam00443
      Location:271 → 676
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:26 → 87
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    RNA

    1. NR_172074.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      30251142..30301185
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079054.2 → XP_038934982.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

      UniProtKB/TrEMBL
      D4A251
      Related
      ENSRNOP00000007465.6, ENSRNOT00000007465.7
      Conserved Domains (2) summary
      pfam00443
      Location:288 → 693
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:43 → 104
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    2. XM_039079061.2 → XP_038934989.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

      UniProtKB/TrEMBL
      D4A251
      Conserved Domains (2) summary
      pfam00443
      Location:288 → 693
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:43 → 104
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    3. XM_063263445.1 → XP_063119515.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X3

      UniProtKB/TrEMBL
      A6IFZ4

    4. XM_063263444.1 → XP_063119514.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

      UniProtKB/TrEMBL
      D4A251

    5. XM_039079063.2 → XP_038934991.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A942
      Conserved Domains (2) summary
      pfam00443
      Location:271 → 676
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:26 → 87
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    6. XM_039079055.2 → XP_038934983.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

      UniProtKB/TrEMBL
      D4A251
      Related
      ENSRNOP00000089591.2, ENSRNOT00000105243.2
      Conserved Domains (2) summary
      pfam00443
      Location:288 → 693
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:43 → 104
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    7. XM_039079060.2 → XP_038934988.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

      UniProtKB/TrEMBL
      D4A251
      Conserved Domains (2) summary
      pfam00443
      Location:288 → 693
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:43 → 104
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    8. XM_039079068.2 → XP_038934996.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A942
      Related
      ENSRNOP00000107316.1, ENSRNOT00000124420.1
      Conserved Domains (2) summary
      pfam00443
      Location:271 → 676
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:26 → 87
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    Nucleotide Protein Strain
    Heading Accession and Version

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