Mal2 mal, T-cell differentiation protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Mal2provided by RGD
Full Name: mal, T-cell differentiation protein 2provided by RGD
Primary source: RGD:735066
See related: EnsemblRapid:ENSRNOG00000008615 AllianceGenome:RGD:735066
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be a structural constituent of myelin sheath. Predicted to be involved in myelination. Is active in glutamatergic synapse and hippocampal mossy fiber to CA3 synapse. Is integral component of synaptic vesicle membrane. Orthologous to human MAL2 (mal, T cell differentiation protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 715.5), Liver (RPKM 352.9) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q32

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (87790239..87823219)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (85900453..85933433)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (94130852..94163649)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that in addition to its role in transcytosis, MAL2 also regulates polymeric IgA receptor delivery from the Golgi to the plasma membrane.
Title: MAL2 selectively regulates polymeric IgA receptor delivery from the Golgi to the plasma membrane in WIF-B cells.
MAL2 is a novel synaptic vesicle protein that is preferentially associated with vesicular glutamate (VGLUT-1)-containing nerve terminals.
Title: Quantitative comparison of glutamatergic and GABAergic synaptic vesicles unveils selectivity for few proteins including MAL2, a novel synaptic vesicle protein.

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General gene information

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Markers

RH130641 (e-PCR)
- UniSTS:213925

D7Got60 (e-PCR)
- UniSTS:115709

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables structural constituent of myelin sheath	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in myelination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	EXP Inferred from Experiment more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle membrane	EXP Inferred from Experiment more info	PubMed
is_active_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein MAL2

Names: MAL2 proteolipid protein; MAL2A; protein MAL2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.