Dlx1 distal-less homeobox 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dlx1provided by RGD
Official Full Name: distal-less homeobox 1provided by RGD
Primary source: RGD:1309593
See related: EnsemblRapid:ENSRNOG00000001520 AllianceGenome:RGD:1309593
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to be involved in several processes, including negative regulation of cellular response to growth factor stimulus; regulation of neuron differentiation; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including forebrain development; negative regulation of Notch signaling pathway; and negative regulation of oligodendrocyte differentiation. Predicted to be located in nucleus. Orthologous to human DLX1 (distal-less homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 36.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 3q23

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (76763864..76768454)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (56356190..56360780)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (58164931..58169521)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rgs5 and Dlx1 represent novel molecular targets for the regulation of ductus arteriosus maturation and closure.
Title: Dlx1 and Rgs5 in the ductus arteriosus: vessel-specific genes identified by transcriptional profiling of laser-capture microdissected endothelial and smooth muscle cells.

Submit: New GeneRIF Correction

General gene information

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Markers

AU048745 (e-PCR)
- UniSTS:145195

BE112823 (e-PCR)
- UniSTS:246196

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within GABAergic neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to BMP stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to BMP stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to BMP stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to transforming growth factor beta stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to transforming growth factor beta stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to transforming growth factor beta stimulus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cerebral cortex GABAergic interneuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in cerebral cortex GABAergic interneuron fate commitment	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cerebral cortex GABAergic interneuron fate commitment	ISO Inferred from Sequence Orthology more info
involved_in embryonic skeletal system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic skeletal system development	ISO Inferred from Sequence Orthology more info
involved_in forebrain neuron differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within forebrain neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in hippocampus development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hippocampus development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of BMP signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of BMP signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of Notch signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cellular response to transforming growth factor beta stimulus	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cellular response to transforming growth factor beta stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cellular response to transforming growth factor beta stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of oligodendrocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of photoreceptor cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of photoreceptor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of photoreceptor cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuroblast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuroblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in neuron apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in odontogenesis of dentin-containing tooth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	ISO Inferred from Sequence Orthology more info
involved_in oligodendrocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of amacrine cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of amacrine cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of amacrine cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in proximal/distal pattern formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proximal/distal pattern formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in subpallium development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within subpallium development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: homeobox protein DLX-1

Names: homeobox Dlx1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.