Itgal integrin subunit alpha L [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Itgalprovided by RGD
Official Full Name: integrin subunit alpha Lprovided by RGD
Primary source: RGD:631424
See related: EnsemblRapid:ENSRNOG00000017980 AllianceGenome:RGD:631424
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: LFA-1
Summary: Predicted to enable ICAM-3 receptor activity and cell adhesion molecule binding activity. Involved in cell-cell adhesion. Located in cell surface. Used to study nephritis. Orthologous to human ITGAL (integrin subunit alpha L). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 439.4), Spleen (RPKM 346.9) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q37

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (191348424..191386228)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (181918183..181955735)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (198744053..198781745)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prenatal alcohol exposure (PAE) creates a risk for developing peripheral neuropathies, and LFA-1 may be a novel therapeutic target for controlling dysregulated neuroimmune actions as a consequence of PAE.
Title: Targeting the β2-integrin LFA-1, reduces adverse neuroimmune actions in neuropathic susceptibility caused by prenatal alcohol exposure.
Downregulated expression of CD11a in an experimental model of depression could be an important mechanisms to induce impaired immune responses in experimental and clinical depression.
Title: Forced swimming test decreases chemotactic responsiveness and expression of CD11a in rat monocytes.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ICAM-3 receptor activity	ISO Inferred from Sequence Orthology more info
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within activated T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in memory T cell extravasation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in receptor clustering	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in immunological synapse	ISO Inferred from Sequence Orthology more info
part_of integrin alphaL-beta2 complex	ISO Inferred from Sequence Orthology more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: integrin alpha-L

Names: integrin, alpha L; lymphocyte function-associated antigen-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033998.2 → NP_001029170.1 integrin alpha-L precursor

See identical proteins and their annotated locations for NP_001029170.1

Status: VALIDATED

Source sequence(s)

BC101849, CR471677, CV076006, DV727670

UniProtKB/TrEMBL

A0A8I5ZT41, Q3T1L6

Related

ENSRNOP00000099014.1, ENSRNOT00000138153.1

Conserved Domains (3) summary

smart00191
Location:514 → 566

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:609 → 977

Integrin_alpha2; Integrin alpha

cl00057
Location:151 → 320

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

191348424..191386228

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006230269.5 → XP_006230331.1 integrin alpha-L isoform X1

UniProtKB/TrEMBL

A0A8I5ZT41, F1LP44

Related

ENSRNOP00000024404.5, ENSRNOT00000024404.8

Conserved Domains (3) summary

smart00191
Location:514 → 566

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:609 → 977

Integrin_alpha2; Integrin alpha

cl00057
Location:151 → 320

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_039078348.2 → XP_038934276.1 integrin alpha-L isoform X2

UniProtKB/TrEMBL

A0A8I5ZT41

Related

ENSRNOP00000107264.1, ENSRNOT00000159025.1

Conserved Domains (4) summary

smart00191
Location:506 → 558

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam00357
Location:1101 → 1115

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:601 → 967

Integrin_alpha2; Integrin alpha

cl00057
Location:143 → 312

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...